Histological and radiographic comparison of allograft substitutes using a continuous delivery model in segmental defects

Biomedical Sciences Instrumentation

Volumn 43, Issue , 2007, Pages 194-199

  Marks, Tyler ^a   Wingerter, Scott ^a   Franklin, Laura ^a   Woodall Jr , James ^a   Tucci, Michelle ^a   Russell, George ^a   Patel, Ramesh ^a   Benghuzzi, Hamed ^a  

^a NONE

Author keywords

Bone healing; Continuous release; Demineralized bone matrix; Drug delivery; Osteogenic protein 1; Segmental defect

Indexed keywords

BONE; DIAGNOSTIC RADIOGRAPHY; DRUG DELIVERY; PHYSIOLOGICAL MODELS; PROTEINS; AMINO ACIDS; ANIMALS; ANTIBIOTICS; CALCINATION; DEFECTS; DRUG DOSAGE; INSTRUMENTS; LANDFORMS; POLYMETHYL METHACRYLATES;

BONE HEALING; CONTINUOUS RELEASE; DEMINERALIZED BONE MATRIX (DBM); OSTEOGENIC PROTEINS; SEGMENTAL DEFECTS;

GRAFTS; BONE;

ANTIBIOTIC AGENT; BONE MORPHOGENETIC PROTEIN; CALCIUM PHOSPHATE; OSTEOGENIC PROTEIN 1;

ALLOGRAFT; ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; BONE DEFECT; BONE GROWTH; BONE MATRIX; BONE REGENERATION; CONFERENCE PAPER; CONTROLLED STUDY; DOSE RESPONSE; DRUG DELIVERY SYSTEM; DRUG RELEASE; HISTOPATHOLOGY; NONHUMAN; RADIOGRAPHY; RAT;

ANIMALS; ANTI-BACTERIAL AGENTS; BONE MORPHOGENETIC PROTEINS; BONE SUBSTITUTES; DELAYED-ACTION PREPARATIONS; DISEASE MODELS, ANIMAL; DRUG COMBINATIONS; FEMORAL FRACTURES; FEMUR; FRACTURE HEALING; RATS; RATS, SPRAGUE-DAWLEY; TOBRAMYCIN; TRANSFORMING GROWTH FACTOR BETA; TRANSPLANTATION, HOMOLOGOUS; TREATMENT OUTCOME;

BONE HEALING; CONTINUOUS RELEASE; DEMINERALIZED BONE MATRIX; OSTEOGENIC PROTEINS; SEGMENTAL DEFECT;

EID: 34247568269     PISSN: 00678856     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (28)

1. T. Kokubo, H. M. Kim, and M. Kawashita, "Novel bioactive materials with different mechanical properties," Biomaterials, vol. 24, pp. 2161-75, 2003.
2. M. R. Urist, "Bone: formation by autoinduction," Science, vol. 150, pp. 893-9, 1965.
3. M. R. Urist and B. S. Strates, "Bone morphogenetic protein," J Dent Res, vol. 50, pp. 1392-406, 1971.
4. T. A. Einhorn, J. M. Lane, A. H. Burstein, C. R. Kopman, and V. J. Vigorita, "The healing of segmental bone defects induced by demineralized bone matrix. A radiographic and biomechanical study," J Bone Joint Surg Am, vol. 66, pp. 274-9, 1984.
5. M. R. Urist, B. F. Silverman, K. Buring, F. L. Dubuc, and J. M. Rosenberg, "The bone induction principle," Clin Orthop Relat Res, vol. 53, pp. 243-83, 1967.
6. M. Gebhart and J. Lane, "A radiographical and biomechanical study of demineralized bone matrix implanted into a bone defect of rat femurs with and without bone marrow," Acta Orthop Belg, vol. 57, pp. 130-43, 1991.
7. P. Kasten, R. Luginbuhl, M. van Griensven, T. Barkhausen, C. Krettek, M. Bohner, and U. Bosch, "Comparison of human bone marrow stromal cells seeded on calcium-deficient hydroxyapatite, beta-tricalcium phosphate and demineralized bone matrix," Biomaterials, vol. 24, pp. 2593-603, 2003.
8. X. Chen, L. S. Kidder, and W. D. Lew, "Osteogenic protein-1 induced bone formation in an infected segmental defect in the rat femur," J Orthop Res, vol. 20, pp. 142-50, 2002.
9. S. D. Cook, S. L. Salkeld, M. R. Brinker, M. W. Wolfe, and D. C. Rueger, "Use of an osteoinductive biomaterial (rhOP-1) in healing large segmental bone defects," J Orthop Trauma, vol. 12, pp. 407-12, 1998.
10. M. W. Wolfe and S. D. Cook, "Use of osteoinductive implants in the treatment of bone defects," Med Prog Technol, vol. 20, pp. 155-68, 1994.
11. M. E. Bolander and G. Balian, "The use of demineralized bone matrix in the repair of segmental defects. Augmentation with extracted matrix proteins and a comparison with autologous grafts," J Bone Joint Surg Am, vol. 68, pp. 1264-74, 1986.
12. D. A. Chakkalakal, A. A. Mashoof, J. Novak, B. S. Strates, and M. H. McGuire, "Mineralization and pH relationships in healing skeletal defects grafted with demineralized bone matrix," J Biomed Mater Res, vol. 28, pp. 1439-43, 1994.
13. D. A. Chakkalakal, B. S. Strates, K. L. Garvin, J. R. Novak, E. D. Fritz, T. J. Mollner, and M. H. McGuire, "Demineralized bone matrix as a biological scaffold for bone repair," Tissue Eng, vol. 7, pp. 161-77, 2001.
14. A. Ehrnberg, J. De Pablos, G. Martinez-Lotti, A. Kreicbergs, and O. Nilsson, "Comparison of demineralized allogeneic bone matrix grafting (the Urist procedure) and the Ilizarov procedure in large diaphyseal defects in sheep," J Orthop Res, vol. 11, pp. 438-47, 1993.
15. J. E. Feighan, D. Davy, A. B. Prewett, and S. Stevenson, "Induction of bone by a demineralized bone matrix gel: a study in a rat femoral defect model," J Orthop Res, vol. 13, pp. 881-91, 1995.
16. C. Galjour, S. Dzugan, M. Graves, H. Benghuzzi, G. Russell, M. Tucci, and A. Tsao, "Stimulation of fracture healing by continuous delivery of demineralized bone matrix proteins and tobramycin," Biomed Sci Instrum, vol. 41, pp. 122-7, 2005.
17. A. Hulth, O. Johnell, and A. Henricson, "The implantation of demineralized fracture matrix yields more new bone formation than does intact matrix," Clin Orthop Relat Res, pp. 235-9, 1988.
18. R. L. Barrack, S. D. Cook, L. P. Patron, S. L. Salkeld, E. Szuszczewicz, and T. S. Whitecloud, 3rd, "Induction of bone ingrowth from acetabular defects to a porous surface with OP-1," Clin Orthop Relat Res, pp. 41-9, 2003.
19. S. D. Cook, G. C. Baffes, M. W. Wolfe, T. K. Sampath, D. C. Rueger, and T. S. Whitecloud, 3rd, "The effect of recombinant human osteogenic protein-1 on healing of large segmental bone defects," J Bone Joint Surg Am, vol. 76, pp. 827-38, 1994.
20. S. D. Cook, S. L. Salkeld, L. P. Patron, M. C. Sargent, and D. C. Rueger, "Healing course of primate ulna segmental defects treated with osteogenic protein-1," J Invest Surg, vol. 15, pp. 69-79, 2002.
21. S. D. Cook, M. W. Wolfe, S. L. Salkeld, and D. C. Rueger, "Effect of recombinant human osteogenic protein-1 on healing of segmental defects in non-human primates," J Bone Joint Surg Am, vol. 77, pp. 734-50, 1995.
22. S. Dzugan, C. Galjour, J. Conflitti, H. Benghuzzi, M. Tucci, G. Russell, and A. Tsao, "Sustained release of OP-1 and antibiotics in treatment of femoral defects in male rats," Biomed Sci Instrum, vol. 41, pp. 80-5, 2005.
23. S. L. Salkeld, L. P. Patron, R. L. Barrack, and S. D. Cook, "The effect of osteogenic protein-1 on the healing of segmental bone defects treated with autograft or allograft bone," J Bone Joint Surg Am, vol. 83-A, pp. 803-16, 2001.
24. P. K. Bajpai and H. A. Benghuzzi, "Ceramic systems for long-term delivery of chemicals and biologicals," J Biomed Mater Res, vol. 22, pp. 1245-66, 1988.
25. D. Bush, B. England, M. Tucci, Z. Cason, L. Lemos, and H. Benghuzzi, "The effect of TCPL devices on tissue-implant interface analysis using adult sheep as a model," Biomed Sci Instrum, vol. 31, pp. 147-52, 1995.
26. H. A. Benghuzzi, R. M. Barbaro, and P. K. Bajpai, "Sustained delivery of 3H-thymidine by means of ceramic capsules in rats," Biomed Sci Instrum, vol. 25, pp. 169-77, 1989.
27. D. A. Bomback, J. N. Grauer, R. Lugo, N. Troiano, T. Patel, and G. E. Friedlaender, "Comparison of posterolateral lumbar fusion rates of Grafton Putty and OP-1 Putty in an athymic rat model," Spine, vol. 29, pp. 1612-7, 2004.
28. J. Conflitti, M. Graves, G. Russell, M. Tucci, and H. Benghuzzi, "Plating of rat femoral shaft osteotomies: report of a technique and preliminary results," Biomed Sci Instrum, vol. 39, pp. 278-83, 2003.