Raman chemical imaging for ingredient-specific particle size characterization of aqueous suspension nasal spray formulations: A progress report

Pharmaceutical Research

Volumn 24, Issue 5, 2007, Pages 934-945

  Doub, William H ^a   Adams, Wallace P ^a   Spencer, John A ^a   Buhse, Lucinda F ^a   Nelson, Matthew P ^b   Treado, Patrick J ^b  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^b ChemImage Corporation   (United States)

Author keywords

Drug delivery; Image analysis; Nasal; Raman; Spectroscopy

Indexed keywords

BECLOMETASONE DIPROPIONATE; BENZALKONIUM CHLORIDE; CARBOXYMETHYLCELLULOSE; CORTICOSTEROID; EXCIPIENT; GLUCOSE; MICROCRYSTALLINE CELLULOSE; MICROSPHERE; NOSE SPRAY; PHENETHYL ALCOHOL; PLACEBO; POLYSORBATE 80; POLYSTYRENE;

ADHESION; AEROSOL; AQUEOUS SOLUTION; ARTICLE; BIREFRINGENCE; DRUG DELIVERY SYSTEM; DRUG FORMULATION; FEASIBILITY STUDY; IMAGING; INTERMETHOD COMPARISON; PARTICLE SIZE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; RAMAN SPECTROMETRY; REFLECTOMETRY; SAMPLE; STANDARD; STATISTICAL ANALYSIS; VALIDATION PROCESS;

AEROSOLS; BECLOMETHASONE; GLUCOCORTICOIDS; MICROSCOPY, ELECTRON, TRANSMISSION; MICROSPHERES; PARTICLE SIZE; PHARMACEUTICAL PREPARATIONS; PHARMACEUTICAL SOLUTIONS; PROGRAM DEVELOPMENT; REGRESSION ANALYSIS; REPRODUCIBILITY OF RESULTS; SPECTRUM ANALYSIS, RAMAN; SUSPENSIONS; TECHNOLOGY, PHARMACEUTICAL; WATER;

EID: 34247565185     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-006-9211-2     Document Type: Article

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