Protective effect of silibinin against isoproterenol-induced injury to cardiac myocytes and its mechanism

Yaoxue Xuebao

Volumn 42, Issue 3, 2007, Pages 263-268

  Zhou, Bei ^a   Wu, Li Jun ^a   Tashiro, Shin Ichi ^b   Onodera, Satoshi ^b   Uchiumi, Fumiaki ^c   Ikejima, Takashi ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b SHOWA PHARMACEUTICAL UNIVERSITY   (Japan)

^c TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

Bcl 2 family proteins; Cardiac myocyte; Injury; Mitochondrial membrane potential; Silibinin; SIRT1

Indexed keywords

BAX PROTEIN, RAT; CARDIOTONIC AGENT; ISOPRENALINE; LACTATE DEHYDROGENASE; MALONALDEHYDE; PROTEIN BAX; PROTEIN BCL 2; SILIBININ; SILYMARIN; SIRT1 PROTEIN, RAT; SIRTUIN; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ANIMAL; ARTICLE; CELL CULTURE; CELL SURVIVAL; CHEMISTRY; DOSE RESPONSE; DRUG EFFECT; HEART MITOCHONDRION; HEART MUSCLE CELL; ISOLATION AND PURIFICATION; MEDICINAL PLANT; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; NEWBORN; PATHOLOGY; PHYSIOLOGY; RAT; SILYBUM MARIANUM; SPRAGUE DAWLEY RAT; UPREGULATION; WESTERN BLOTTING;

ANIMALS; ANIMALS, NEWBORN; BCL-2-ASSOCIATED X PROTEIN; BLOTTING, WESTERN; CARDIOTONIC AGENTS; CELL SURVIVAL; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ISOPROTERENOL; L-LACTATE DEHYDROGENASE; MALONDIALDEHYDE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MILK THISTLE; MITOCHONDRIA, HEART; MYOCYTES, CARDIAC; PLANTS, MEDICINAL; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, SPRAGUE-DAWLEY; SILYMARIN; SIRTUINS; SUPEROXIDE DISMUTASE; UP-REGULATION;

EID: 34247556160     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Zeng GY, Xu XW, Liu HX. Experimental models of heart failure [J]. Acta Pharm Sin, 2002, 37:579-585.
2. Araki M, Hasegawa K, Iwai-Kanai E. Endothelin-1 as a protective factor against beta-adrenergic agonist-induced apoptosis in cardiac myocytes [J]. J Am Coll Cardiol, 2000, 36:1411-1418.
3. Communal C, Singh K, Pimentel DR, et al. Norepinephrine stimulates apoptosis in adult rat ventricular myocytes by activation of the β-adrenergic pathway [J]. Circulation, 1998, 98:1329-1334.
4. Gao SJ, Zeng GY. Cardiotonic and toxic effects of peruvoside and neriifolim [J]. Acta Pharm Sin, 1983, 18:572-578.
5. Wang HM, Lian HX, Xu JJ, et al. The preventive effects of silibinin on the cardiac toxicity caused by doxorubicin [J]. Adverse Drug React J, 2003, 5:371-374.
6. Chen H, Su DF, Zhang TH. Effects of silybinin on acute myocardial infarction and reperfusion injury in anesthetized rats [J]. Acta Pharmacol Sin, 1992, 13:69-71.
7. Ferenci P, Dragosics B, Dittrich H, et al. Randomized controlled trial of silymarin treatment in patients with cirrhosis of the liver [J]. J Hepatol, 1989, 9:105-113.
8. Barth E, Stammler C, Speiser B, et al. Ultrastructural quantitation of mitochondria and myofilaments in cardiac muscle from 10 different animal species including man [J]. J Mol Cell Cardiol, 1992, 24:669-681.
9. 1-adrenergic-stimulated hypertrophy in cultured neonatal rat cardiac myocytes [J]. Circulation, 1999, 99:292-298.
10. Lasek W, Wankowicz A, Kuc K, et al. Augmentation of antitumor efficacy by the combination of actinomycin D with tumor necrosis factor-alpha and interferon-gamma on amelanoma model in mice [J]. Cancer Immunol Immunother, 1995, 40:315-321.
11. Sayen MR, Gustafsson AB, Sussman MA, et al. Calcineurin transgenic mice have mitochondrial dysfunction and elevated Superoxide production [J]. Am J Physiol Cell Physiol, 2003, 284:562-570.
12. Suzuki K, Hino M, Kutsuna H, et al. Selective activation of p38 mitogen-activated protein kinase cascade in human neutrophils stimulated by IL-1β [J]. J Immunol, 2001, 167:5940-5947.
13. Torras J, Seron D, Herrero I, et al. Renal protective effect of liposomed superoxide dismutase in an experimental warm ischemia model [J]. Transpl Int, 1994, 7:8472-475.
14. Anand K, Brar R, Wang P, et al. Role of nitric oxide and cGMP in human septic serum-induced depression of cardiac myocyte contractility [J]. Am Physiol Soc, 1999, 276:265-277.
15. Green DR, Reed JC. Mitochondria and apoptosis [J]. Science, 1998, 281:1309-1312.
16. Scorrano L, Korsmeyer SJ, Mechanisms of cytochrome c release by proapoptotic Bcl-2 family members [J]. Biochem Biophys Res Commun, 2003, 304:437-444.
17. Wang C, Wang MW, Tashiro SI, et al. Effect of protein kinase C on human melanoma A375-S2 cell death induced by evodiamine [J]. Acta Pharm Sin, 2005, 40:1033-1036.
18. Giannakou ME, Partridge L. The interaction between FOXO and SIRT1: tipping the balance towards survival [J]. Trends Cell Biol, 2004, 14:408-412.