DNA-enzyme-mediated cleavage of human immunodeficiency virus type 1 Gag RNA is significantly augmented by antisense-DNA molecules targeted to hybridize close to the cleavage site

Oligonucleotides

Volumn 17, Issue 1, 2007, Pages 113-121

  Sood, Vikas ^a   Gupta, Nidhi ^a   Bano, Aalia Sahar ^a   Banerjea, Akhil C ^a,b  

^a NATIONAL INSTITUTE OF IMMUNOLOGY   (India)

^b JAWAHARLAL NEHRU UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; GAG PROTEIN; OLIGODEOXYNUCLEOTIDE; VIRUS RNA;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; ARTICLE; DNA HYBRIDIZATION; GENE REPRESSION; GENE TARGETING; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; RNA SEQUENCE; RNA STRUCTURE;

BASE SEQUENCE; DNA, ANTISENSE; DNA, CATALYTIC; GENES, GAG; HIV-1; HUMANS; NUCLEIC ACID HYBRIDIZATION; OLIGODEOXYRIBONUCLEOTIDES, ANTISENSE; RIBONUCLEASE H, CALF THYMUS; RNA, VIRAL;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 34247533679     PISSN: 15454576     EISSN: None     Source Type: Journal    
DOI: 10.1089/oli.2007.9998     Document Type: Article

References (27)

1. ACKERMANN, J.M., KANUGULA, S., and PEGG, A.E. (2005). DNAzyme-mediated silencing of ornithine decarboxylase. Biochemistry 44, 2143-2152.
2. ADACHI, A., GLENDELMAN, H.E., KOENIG, S., FOLKS, T., WILLEY, R., RABSOM, A., and MARTIN, M. (1986). Production of acquired immunodeficiency syndrome associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone. J. Virol. 59, 284-291.
3. AKKINA, R., BANERJEA, A., BAI, J., ANDERSON, J., LI, M.J., and ROSSI, J. (2003). siRNAs, ribozymes and RNA decoys in modeling stem cell-based gene therapy for HIV/AIDS. Anticancer Res. 23, 1997-2005.
4. BANERJEA, A.C., and JOKLIK, W.K. (1990). Reovirus protein σ1 translated in vitro as well as truncated derivatives of that lack up to two-thirds of its C-terminal portion, exists as two major tetramolecular species that differ in electrophoretic mobility. Virology 179, 460-462.
5. BANERJEA, A.C., CHAKRABORTI, S., UNWALLA, H., GOILA, R., SHRABANI, S., DASH, B.C., SRIRAM, B., PARAMASIVAM, N., and VISWANATHAN, S. (2004). Potential therapeutic applications of DNA-enzymes and siRNAs against viral and cellular genes. In: Synthetic Nucleic Acids As Inhibitors of Gene Expression: Mechanisms, Applications, and Therapeutic implications. Khachigian, L.M., ed. (CRC Press, Florida) pp. 115-134.
6. CHAKRABORTI, S., and BANERJEA, A.C. (2003a). Identification of cleavage sites in the HIV-1 TAR RNA by 10-23 and 8-17 catalytic motif containing DNA-enzymes Biomacromolecules 4, 568-571.
7. CHAKRABORTI, S., and BANERJEA, A.C. (2003b). Inhibition of HIV-1 replication by 10-23 catalytic motif containing DNA-enzymes targeted against HIV-1 TAR element: Potential effectiveness against all HIV-1 isolates. Mol. Ther. 7, 817-826.
8. CRUZ, R.P.G., WITHERS, J.B., and LI, Y. (2004). Dinucleotide junction cleavage versatility of 8-17 deoxyribozyme. Chem. Biol. 11, 57-67.
9. DASH, B.C., and BANERJEA, A.C. (2004). Sequence specific cleavage activities of DNA-enzymes targeted against HIV-1 Gag and Nef regions. Oligonucleotides 14, 41-47.
10. GOILA, R., and BANERJEA, A.C. (1998). Sequence specific cleavage of the HIV-1 coreceptor-CCR5 gene by a hammerhead ribozyme and a DNA-enzyme: Inhibition of the coreceptor function by DNA-enzyme. FEBS Lett. 436, 233-238.
11. GOILA, R., and BANERJEA, A.C. (2001). Inhibition of hepatitis B virus X gene expression by novel DNAenzymes. Biochem. J. 353, 701-708.
12. GOODCHILD, J. (1992). Enhancement of ribozyme catalytic activity by a contiguous oligonucleotide (facilitator) and by 2′-O-methylation. Nucleic Acids Res. 20, 4607-4612.
13. GOODCHILD, J. (2004). Oligonucleotide therapeutics: 25 years and growing. Curr. Opin. Mol. Ther. 6, 120-128.
14. HORN, S., and SCHWENZER, B. (1999). Oligonucleotide facilitators enhance the catalytic activity of RNA-cleaving DNA enzymes. Antisense Nucleic Acid Drug Dev. 9, 465-472.
15. HUSAIN, S., GOILA, R., SHAHI, S., and BANERJEA, A.C. (1998). First report of a healthy Indian heterozygous for Δ32 mutant of HIV-1 coreceptor-CCR5 gene Gene 207, 141-147.
16. JANKOWSKY, E., and SCHWENZER, B. (1996). Oligonucleotide facilitators may inhibit or activate a hammerhead ribozyme. Nucleic Acids Res. 24, 423-429.
17. JOYCE, G.F. (2004). Directed evolution of nucleic acid enzymes. Annu. Rev. Biochem. 73, 791-836.
18. KURRECK, J., BIEBER, B., JAHNEL, R. and ERDMANN, V.A. (2002a). Comparative study of DNA enzymes and ribozymes against the same full-length messenger RNA of the Vanilloid receptor subtype 1. J. Biol. Chem. 277, 7099-7107.
19. KURRECK, J., WYSZKO, E., GILLEN, C., and ERDMANN, V.A. (2002b). Design of antisense oligonucleotides stabilized by locked nucleic acids. Nucleic Acids Res. 30, 1911-1918.
20. LEE, N.S., DOHJIMA, T., BAUER, G., LI, H., LI, MJ., EHSANI, A., SALVATERRA, P., and ROSSI, J. (2002). Expression of small interfering RNAs targeted against HIV-1 rev transcripts in human cells. Nature Biotechnol. 20, 500-505.
21. PERACCHI, A., BONACCIO, M., and CLERICI, M. (2005). A mutational analysis of the 8-17 deoxyribozyme core. J. Mol. Biol. 352, 783-794.
22. SANTORO, S.W., and JOYCE, G.F. (1997). General purpose RNA-cleaving DNA enzyme. Proc. Natl. Acad. Sci. USA 94, 4262-4266.
23. SCHUBERT, S., FURSTE, J.P., WERK, D., GRUNERT, H. P., ZEICHHARDT, H., ERDMANN V.A., and KURRECK, J. (2004). Gaining target access for deoxyribozymes. J. Mol. Biol. 339, 355-363.
24. SILVERMAN, S.K. (2005). in vitro selection, characterization, and application of deoxyribozymes that cleave RNA. Nucleic Acids Res. 33, 6151-6163.
25. WADHWA R., ANDO, H., KAWASAKI, H., TAIRA, K., and KAUL, S.C. (2003). Targeting mortalin using conventional and RNA-helicase-coupled hammerhead ribozymes. EMBO Rep. 4, 595-601.
26. WANG, DY., and SEN, D. (2001). A novel mode of regulation of an RNA-cleaving DNAzyme by effectors that bind to both enzyme and substrate. J. Mol. Biol. 310, 723-734.
27. WANG, D.Y., BEATRICE, H.Y.L., FELDMAN, A.R., and SEN, D. (2002). A general approach for the use of oligonucleotide effectors to regulate the catalysis of RNA cleaving ribozymes and DNAzymes. Nucleic Acids Res. 30, 1735-1742.