Effect of Intravenous Nicorandil and Preexisting Angina Pectoris on Short- and Long-Term Outcomes in Patients With a First ST-Segment Elevation Acute Myocardial Infarction

American Journal of Cardiology

Volumn 99, Issue 9, 2007, Pages 1203-1207

  Ishii, Hideki ^a,c   Ichimiya, Satoshi ^c   Kanashiro, Masaaki ^c   Amano, Tetsuya ^a   Ogawa, Yasuhiro ^a   Mitsuhashi, Hirotsugu ^a   Sakai, Shinichi ^a,c   Uetani, Tadayuki ^a   Murakami, Ryuichiro ^a   Naruse, Keiko ^b   Murohara, Toyoaki ^a   Matsubara, Tatsuaki ^b  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b AICHI GAKUIN UNIVERSITY   (Japan)

^c Yokkaichi Municipal Hospital   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

NICORANDIL; PLACEBO;

ACUTE HEART INFARCTION; ADULT; AGED; ANGINA PECTORIS; ARTICLE; CARDIAC PATIENT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; HEART PROTECTION; HUMAN; ISCHEMIC PRECONDITIONING; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PERCUTANEOUS CORONARY INTERVENTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; ST SEGMENT ELEVATION;

AGED; ANGINA PECTORIS; ANGIOPLASTY, TRANSLUMINAL, PERCUTANEOUS CORONARY; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; FEMALE; FOLLOW-UP STUDIES; HUMANS; INFUSIONS, INTRAVENOUS; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; NICORANDIL; TIME FACTORS; TREATMENT OUTCOME; VASODILATOR AGENTS;

EID: 34247485884     PISSN: 00029149     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.amjcard.2006.12.034     Document Type: Article

References (27)

1. Sakata Y., Kodama K., Komamura K., Lim Y.J., Ishikura F., Hirayama A., Kitakaze M., Masuyama T., and Hori M. Salutary effect of adjunctive intracoronary nicorandil administration on restoration of myocardial blood flow and functional improvement in patients with acute myocardial infarction. Am Heart J 133 (1997) 616-621
2. Taira N. Nicorandil as a hybrid between nitrates and potassium channel activators. Am J Cardiol 63 suppl (1989) 18J-24J
3. Auchampach J.A., Cavero I., and Gross G.J. Nicorandil attenuates myocardial dysfunction associated with transient ischemia by opening ATP-dependent potassium channels. J Cardiovasc Pharmacol 20 (1992) 765-771
4. Kempsford R.D., and Hawgood B.J. Assessment of the antiarrhythmic activity of nicorandil during myocardial ischemia and reperfusion. Eur J Pharmacol 163 (1989) 61-68
5. Ito H., Taniyama Y., Iwakura K., Nishikawa N., Masuyama T., Kuzuya T., Hori M., Higashino Y., Fujii K., and Minamino T. Intravenous nicorandil can preserve microvascular integrity and myocardial viability in patients with reperfused anterior wall myocardial infarction. J Am Coll Cardiol 33 (1999) 654-660
6. The IONA Study Group. Effect of nicorandil on coronary events in patients with stable angina: the Impact Of Nicorandil in Angina (IONA) randomised trial. Lancet 359 (2002) 1269-1275
7. Ishii H., Ichimiya S., Kanashiro M., Amano T., Imai K., Murohara T., and Matsubara T. Impact of a single intravenous administration of nicorandil before reperfusion in patients with ST-segment elevation myocardial infarction. Circulation 112 (2005) 1284-1288
8. Ishii H., Ichimiya S., Kanashiro M., Amano T., Matsubara T., and Murohara T. Effects of intravenous nicorandil before reperfusion for acute myocardial infarction in patients with stress hyperglycemia. Diabetes Care 29 (2006) 202-206
9. Matsubara T., Minatoguchi S., Matsuo H., Hayakawa K., Segawa T., Matsuno Y., Watanabe S., Arai M., Uno Y., Kawasaki M., et al. Three minute, but not one minute, ischemia and nicorandil have a preconditioning effect in patients with coronary artery disease. J Am Coll Cardiol 35 (2000) 345-351
10. van't Hof A.W.J., Liem A., de Boer M.J., Zijlstra F., and Zwolle Myocardial Infarction Study Group. Clinical value of 12-lead electrocardiogram after successful reperfusion therapy for acute myocardial infarction. Lancet 350 (1997) 615-619
11. Gibson C.M., Cannon C.P., Daley W.L., Dodge J.T., Alexander B., Marble S.J., McCabe C.H., Raymond L., Fortin T., Poole W.K., and Braunwald E. TIMI frame count: a quantitative method of assessing coronary artery flow. Circulation 93 (1996) 879-888
12. Ishihara M., Sato H., Tateishi H., Kawagoe T., Shimatani Y., Kurisu S., Sakai K., and Ueda K. Implications of prodromal angina pectoris in anterior wall acute myocardial infarction: acute angiographic findings and long-term prognosis. J Am Coll Cardiol 30 (1997) 970-975
13. TIMI-9B Investigators. Prospective temporal analysis of the onset of preinfarction angina versus outcome: an ancillary study in TIMI-9B. Circulation 97 (1998) 1042-1045
14. Shiraki H., Yoshikawa T., Anzai T., Negishi K., Takahashi T., Asakura Y., Akaishi M., Mitamura H., and Ogawa S. Association between preinfarction angina and a lower risk of right ventricular infarction. N Engl J Med 338 (1998) 941-947
15. Nichols C.G., Ripoll C., and Lederer W.J. ATP-sensitive potassium channel modulation of the guinea pig ventricular action potential and contraction. Circ Res 68 (1991) 280-287
16. Auchampach J.A., Maruyama M., Cavero I., and Gross G.J. Pharmacological evidence for a role of ATP-dependent potassium channels in myocardial stunning. Circulation 86 (1992) 311-319
17. + channels. A possible mechanistic link to ischemic preconditioning. Circ Res 79 (1996) 399-406
18. Yellon D.M., and Downey J.M. Preconditioning the myocardium: from cellular physiology to clinical cardiology. Physiol Rev 83 (2003) 1113-1151
19. ATP channels ischemic preconditioning of the canine heart. Am J Physiol Heart Circ Physiol 280 suppl (2001) H256-H263
20. + channels. Am J Physiol 270 suppl (1996) H1744-H1756
21. Liu Y., Sato T., O'Rourke B., and Marban E. Mitochondrial ATP-dependent potassium channels. Novel effectors of cardioprotection?. Circulation 97 (1998) 2463-2469
22. ATP channel activation induces ischemic preconditioning of the endothelium in humans in vivo. Circulation 110 (2004) 2077-2082
23. Sato T., Sasaki N., O'Rourke B., and Marbán E. Nicorandil, a potent cardioprotective agent, acts by opening mitochondrial ATP-dependent potassium channels. J Am Coll Cardiol 35 (2000) 514-518
24. Akao M., Teshima Y., and Marbán E. Antiapoptotic effect of nicorandil mediated by mitochondrial ATP-sensitive potassium channels in cultured cardiac myocytes. J Am Coll Cardiol 40 (2002) 803-810
25. Nagata K., Obata K., Odashima M., Yamada A., Somura F., Nishizawa T., Ichihara S., Izawa H., Iwase M., Hayakawa A., Murohara T., and Yokota M. Nicorandil inhibits oxidative stress-induced apoptosis in cardiac myocytes through activation of mitochondrial ATP-sensitive potassium channels and a nitrate-like effect. J Mol Cell Cardiol 35 (2003) 1505-1512
26. Ozcan C., Bienengraeber M., Dzeja P.P., and Terzic A. Potassium channel openers protect cardiac mitochondria by attenuating oxidant stress at reoxygenation. Am J Physiol Heart Circ Physiol 282 suppl (2002) H531-H539
27. Iwai T., Tanonaka K., Motegi K., Inoue R., Kasahara S., and Takeo S. Nicorandil preserves mitochondrial function during ischemia in perfused rat heart. Eur J Pharmacol 446 (2002) 119-127