Efficacy and Safety of a Very-Low-Protein Diet When Postponing Dialysis in the Elderly: A Prospective Randomized Multicenter Controlled Study

American Journal of Kidney Diseases

Volumn 49, Issue 5, 2007, Pages 569-580

  Brunori, Giuliano ^a   Viola, Battista F ^a   Parrinello, Giovanni ^b   De Biase, Vincenzo ^c   Como, Giovanna ^d   Franco, Vincenzo ^e   Garibotto, Giacomo ^f   Zubani, Roberto ^a,b   Cancarini, Giovanni C ^a,b  

^a Division of Nephrology   (Italy)

^b UNIVERSITY OF BRESCIA   (Italy)

^c UNIVERSITY HOSPITAL OF VERONA   (Italy)

^d FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

^e Division of Nephrology   (Italy)

^f UNIVERSITY OF GENOA   (Italy)

Author keywords

Dialysis; elderly; hemodialysis; low protein diet; morbidity; mortality; peritoneal dialysis; treatment outcome; vegan diet

Indexed keywords

AMINO ACID; VITAMIN;

AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; FEMALE; FOLLOW UP; GLOMERULUS FILTRATION RATE; HUMAN; HYPERKALEMIA; KIDNEY DISEASE; MAJOR CLINICAL STUDY; MALE; MALNUTRITION; MORTALITY; MULTICENTER STUDY; PROTEIN RESTRICTION; RANDOMIZED CONTROLLED TRIAL; RENAL REPLACEMENT THERAPY; SAFETY; TREATMENT OUTCOME; UREMIA;

AGED; AGED, 80 AND OVER; DIET, PROTEIN-RESTRICTED; FEMALE; FOLLOW-UP STUDIES; HUMANS; KIDNEY FAILURE, CHRONIC; MALE; PROSPECTIVE STUDIES; RENAL DIALYSIS; SURVIVAL RATE; TIME FACTORS;

EID: 34247468432     PISSN: 02726386     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.ajkd.2007.02.278     Document Type: Article

References (41)

1. National Kidney Foundation. KDOQI Clinical Practice Guidelines. I. Initiation of dialysis. Am J Kidney Dis 30 suppl 2 (1997) S70-S73
2. Churchill D.N., Blake P.G., Jindal K.K., Toffelmire E.B., and Goldstein M.B. Clinical practice guidelines for initiation of dialysis. J Am Soc Nephrol 10 suppl 13 (1999) S287-S321
3. European Best Practice Guidelines Expert Group on Hemodialysis, and European Renal Association. Section I. Measurement of renal function, when to refer and when to start dialysis. Nephrol Dial Transplant 17 suppl 7 (2002) S7-S15
4. European Best Practice Guideline Working Group on Peritoneal Dialysis, and Krediet R.T. The initiation of dialysis. Nephrol Dial Transplant 20 suppl 9 (2005) Six3-Six7
5. Jansen M.A.M., Korevaar J.C., Dekker F.W., Jager K.J., Boeschoten E.W., Krediet R.T., and NECOSAD Study Group. Renal function and nutritional status at the start of chronic dialysis treatment. J Am Soc Nephrol 12 (2001) 157-163
6. Obrador G.T., Arora P., Kausz A.T., Ruthazer R., Pereira B.J., and Levey A.S. Level of renal function at the initiation of dialysis in the U.S. end-stage renal disease population. Kidney Int 56 (1999) 2227-2235
7. Rayner H.C., Pisoni R.L., Bommer J., et al. Mortality and hospitalization in haemodialysis patients in five European countries: Results from the Dialysis Outcomes and Practice Patterns Study (DOPPS). Nephrol Dial Transplant 19 (2004) 108-120
8. Giovannetti S., Barsotti G., Morelli E., et al. Chronic renal insufficiency. Low-protein diet supplemented with essential amino acids and ketoanalogues. Minerva Med 71 (1980) 2415-2430
9. Aparicio M., Chauveau P., De Precigout V., Bouchet J.L., Lasseur C., and Combe C. Nutrition and outcome on renal replacement therapy of patients with chronic renal failure treated by a supplemented very low protein diet. J Am Soc Nephrol 11 (2000) 708-716
10. Levey A.S., Greene T., Beck G.J., et al. Dietary protein restriction and the progression of chronic renal disease: What have all of the results of the MDRD Study shown?. J Am Soc Nephrol 10 (1999) 2426-2439
11. Teschan P.E., Beck G.J., Dwyer J.T., et al. Effect of a keto-acid-aminoacid-supplemented very low protein diet on the progression of advanced renal disease: A reanalysis of the MDRD feasibility study. Clin Nephrol 50 (1998) 273-283
12. Klahr S., Levey A.S., Beck G.J., et al. The effects of dietary protein restriction and blood-pressure control on the progression of chronic renal disease. Modification of Diet in Renal Disease Study Group. N Engl J Med 330 (1994) 877-884
13. Maiorca R., Brunori G., Gregorini G., et al. Very low protein diet in elderly ESRD patients prolongs residual renal function, improves survival and dialysis can be started late. J Am Soc Nephrol 9 (1998) 154A (abstr)
14. Maiorca R., Brunori G., Viola B.F., et al. Diet or dialysis in the elderly? The DODE Study: A prospective randomized multicenter trial. J Nephrol 13 (2000) 267-270
15. Maroni B.J., Steinman T.I., and Mitch W.E. A method for estimating nitrogen intake of patients with chronic renal failure. Kidney Int 27 (1985) 58-65
16. Daugirdas J.T. Second generation logarithmic estimates of single-pool variable volume Kt/V: An analysis of error. J Am Soc Nephrol 4 (1993) 1205-1213
17. Watson P.E., Watson I.D., and Batt R.D. Total body water volumes for adult males and females estimated from simple anthropometric measurements. Am J Clin Nutr 33 (1980) 27-39
18. National Kidney Foundation. K/DOQI Clinical Practice Guidelines for Peritoneal Dialysis Adequacy: Update 2000. Am J Kidney Dis 37 suppl 1 (2001) S65-S136
19. National Kidney Foundation. K/DOQI Clinical Practice Guidelines for Hemodialysis Adequacy: Update 2000. Am J Kidney Dis 37 suppl 1 (2001) S7-S64
20. Blackwelder W.C. Proving the "null hypothesis" in clinical trials. Control Clin Trials 3 (1982) 345-353
21. Com-Nougue C., Rodary C., and Patte C. How to establish equivalence when data are censored: A randomized trial of treatments for B non-Hodgkin lymphoma. Stat Med 12 (1993) 1353-1364
22. Kaplan E.L., and Meier P. Non-parametric estimation from incomplete observations. J Am Stat Assoc 53 (1958) 457-481
23. Cox D.R. Regression models and life tables (with discussion). J Royal Stat Soc B 34 (1972) 197-220
24. Therneau T.M., and Grambsch P.M. Modeling Survival Data Extending the Cox Model (2000), Springer-Verlag, New York, NY
25. Klein J.P., and Moeschberger M.L. Survival Analysis: Techniques for Censored and Truncated Data. ed 2 (2003), Springer, New York, NY
26. Traynor J.P., Simpson K., Geddes C.C., Deighan C.J., and Fox J.G. Early initiation of dialysis fails to prolong survival in patients with end-stage renal failure. J Am Soc Nephrol 13 (2002) 2125-2132
27. Churchill D.N., Taylor D.W., and Keshaviah P.R. Adequacy of dialysis and nutrition in continuous peritoneal dialysis: Association with clinical outcomes. J Am Soc Nephrol 7 (1996) 198-207
28. Maiorca R., Brunori G., Zubani R., et al. Predictive value of dialysis adequacy and nutritional indices for mortality and morbidity in CAPD and HD patients. A longitudinal study. Nephrol Dial Transplant 10 (1995) 2295-2305
29. Korevaar J.C., Jansen M.A.M., Dekker F.W., et al. When to initiate dialysis: Effect of proposed US guidelines on survival. Lancet 358 (2001) 1046-1105
30. Beddhu S., Samore M.H., Roberts M.S., et al. Impact of timing of initiation of dialysis on mortality. J Am Soc Nephrol 14 (2003) 2305-2312
31. Kazmi W.H., Gilbetson D.T., Obrador G.T., et al. Effect of the increased mortality associated with early initiation of dialysis. Am J Kidney Dis 46 (2005) 887-896
32. Fink J.C., Burdick R.A., Kurth S.J., et al. Significance of serum creatinine values in new end-stage renal disease patients. Am J Kidney Dis 34 (1999) 694-701
33. Kausz A.T., Obrador G.T., Arora P., Ruthazer R., Levey A.S., and Pereira B.J.G. Late initiation of dialysis among women and ethnic minorities in the United States. J Am Soc Nephrol 11 (2000) 2351-2357
34. Aparicio M., Chauveau P., and Combe C. Are supplemented low-protein diets nutritionally safe?. Am J Kidney Dis 37 suppl 2 (2001) S71-S76
35. Walser M., and Hill S. Can renal replacement be deferred by a supplemented very low protein diet?. J Am Soc Nephrol 10 (1999) 110-116
36. Gersch M.S. Treatment of dialysis catheter infection in 2004. J Vasc Access 5 (2004) 99-108
37. Jafar T.H. The growing burden of chronic kidney disease in Pakistan. N Engl J Med 354 (2006) 995-997
38. Barsoum R.S. Chronic kidney disease in the developing world. N Engl J Med 354 (2006) 997-999
39. The National Service Framework for Renal Services. Part 2: Chronic Kidney Disease, Acute Renal Failure and End of Life Care (2006). http://www.dh.gov.uk Available at: http://www.dh.gov.uk. Accessed July 7
40. Smith C., Da Silva-Gane M., Chandna S., Warwicker P., Greenwood R., and Farrington K. Choosing not to dialyse: Evaluation of planned non-dialytic management in a cohort of patients with end-stage renal failure. Nephron Clin Pract 95 (2003) c40-c46
41. Murtagh F.E., Murphy E., Shepherd K.A., Donohoe P., and Edmonds P.M. End-of-life care in end-stage renal disease: Renal and palliative care. Br J Nurs 15 (2006) 8-11