In situ entry of oligonucleotides into brain cells can occur through a nucleic acid channel

Oligonucleotides

Volumn 17, Issue 1, 2007, Pages 122-133

  Shi, Fuxin ^a,d,e   Gounko, Natasha V ^a   Wang, Xiaoqin ^b   Ronken, Eric ^c   Hoekstra, Dick ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b Biomade Technology Foundation   (Netherlands)

^c SoIvay Pharmaceuticals Research Laboratories   (Netherlands)

^d HARVARD MEDICAL SCHOOL   (United States)

^e MASSACHUSETTS EYE AND EAR INFIRMARY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; ANTISENSE OLIGONUCLEOTIDE; LIPOSOME; NUCLEIC ACID; OLIGONUCLEOTIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTISENSE THERAPY; ARTICLE; BOLUS INJECTION; BRAIN CELL; BRAIN SLICE; BRAIN TISSUE; CELL NUCLEUS; CONTINUOUS INFUSION; CYTOSOL; DEGENERATIVE DISEASE; DOWN REGULATION; ENDOCYTOSIS; GENE TRANSLOCATION; IN VITRO STUDY; IN VIVO STUDY; INTERNALIZATION; MEMBRANE DAMAGE; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMID; PRIORITY JOURNAL; RAT;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; ANTIBODIES; BRAIN; CATIONS; CELL NUCLEUS; KIDNEY; LIPIDS; NUCLEIC ACIDS; OLIGONUCLEOTIDES; PLASMIDS; RATS; RATS, SPRAGUE-DAWLEY; TISSUE DISTRIBUTION;

RATTUS;

EID: 34247464641     PISSN: 15454576     EISSN: None     Source Type: Journal    
DOI: 10.1089/oli.2007.0034     Document Type: Article

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