Lower airways inflammation in allergic rhinitics: A comparison with asthmatics and normal controls

Clinical and Experimental Allergy

Volumn 37, Issue 5, 2007, Pages 688-695

  Brown, J L ^a   Behndig, A F ^b   Sekerel, B E ^a   Pourazar, J ^b   Blomberg, A ^b   Kelly, F J ^c   Sandstrom T ^b   Frew, A J ^a   Wilson, S J ^a,d  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b UMEÅ UNIVERSITY HOSPITAL   (Sweden)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

Author keywords

Allergic rhinitis; Asthma; Bronchial mucosa; Cytokine; Inflammation

Indexed keywords

2 HYDROXYETHYL METHACRYLATE; CD3 ANTIGEN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 1BETA; MESSENGER RNA; RESIN; TUMOR NECROSIS FACTOR ALPHA; VASCULAR ADHESION PROTEIN 1;

ADULT; ALLERGIC ASTHMA; ALLERGIC RHINITIS; ARTICLE; BRONCHITIS; BRONCHOSCOPY; BRONCHUS BIOPSY; BRONCHUS MUCOSA; CD8+ T LYMPHOCYTE; CELL SWELLING; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROL GROUP; CONTROLLED STUDY; CYTOKINE RELEASE; DOWN REGULATION; ENDOTHELIUM; EOSINOPHIL; EOSINOPHIL COUNT; FEMALE; FREEZING; HUMAN; IMMUNOHISTOCHEMISTRY; INFLAMMATION; LOWER RESPIRATORY TRACT; MALE; MAST CELL; ONCOGENE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RESPIRATORY EPITHELIUM; RESPIRATORY TRACT ALLERGY; RESPIRATORY TRACT INFLAMMATION;

ADOLESCENT; ADULT; ASTHMA; BRONCHITIS; BRONCHOSCOPY; CYTOKINES; EOSINOPHILIA; FEMALE; FORCED EXPIRATORY VOLUME; HUMANS; IMMUNOENZYME TECHNIQUES; MALE; MAST CELLS; POLYMERASE CHAIN REACTION; RHINITIS; RHINITIS, ALLERGIC, PERENNIAL; RHINITIS, ALLERGIC, SEASONAL; SKIN TESTS; T-LYMPHOCYTE SUBSETS; VASCULAR CELL ADHESION MOLECULE-1;

EID: 34247382142     PISSN: 09547894     EISSN: 13652222     Source Type: Journal    
DOI: 10.1111/j.1365-2222.2007.02695.x     Document Type: Article

References (58)

1. Burr ML, Butland BK, King S, Vaughan-Williams E. Changes in asthma prevalence: two surveys 15 years apart. Arch Dis Child 1989 64: 1452 6.
2. Haahtela T, Lindholm H, Bjorksten F, Koskenvuo K, Latitinen LA. Prevalence of asthma in Finnish young men. BMJ 1990 301: 266 8.
3. Ciprandi G, Vizzaccaro A, Cirillo I, Crimi P, Canonica GW. Increase of asthma and allergic rhinitis prevalence in young Italian men. Int Arch Allergy Immunol 1996 111: 278 83.
4. Sly RM. Changing prevalence of allergic rhinitis and asthma. Ann Allergy Asthma Immunol 1999 82: 233 48.
5. Corren J. Allergic rhinitis and asthma: how important is the link? J Allergy Clin Immunol 1997 99: S781 6.
6. Greisner WA, Settipane RJ, Settipane GA. The course of asthma parallels that of allergic rhinitis: a 23-year follow-up study of college students. Allergy Asthma Proc 2000 21: 371 5.
7. Weiss ST, Tager IB, Speizer FE, Rosner B. Persistent wheeze: its relation to respiratory illness, cigarette smoking and level of pulmonary function in a population sample of children. Am Rev Respir Dis 1980 22: 697 708.
8. Sherman CB, Tosteson TD, Tager IB, Speizer FE, Weiss ST. Early predictors of asthma. Am J Epidemiol 1990 132: 83 95.
9. Wright AL, Holberg CJ, Martinez FD, Halonen M, Morgan W, Taussig LM. Epidemiology of physician-diagnosed allergic rhinitis in childhood. Pediatrics 1994 94: 895 901.
10. Laprise C, Boulet L-P. Asymptomatic airway hyperresponsiveness: a three-year follow-up. Am J Crit Care Med 1997 156: 403 9.
11. Barnes PJ. New concepts in the pathogenesis of bronchial hyperresponsiveness and asthma. J Allergy Clin Immunol 1989 83: 1013 26.
12. Kay AB. Asthma and inflammation. J Allergy Clin Immunol 1991 87: 893 910.
13. Sparrow D, O'Connor G, Colton T, Barry CL, Weiss ST. The relationship of nonspecific bronchial hyperresponsiveness to the occurrence of respiratory symptoms and decreased levels of pulmonary function: the Normative Aging Study. Am Rev Respir Dis 1987 135: 1255 60.
14. Hopp RJ, Townley RG, Biven RE, Bewtra AK, Nair NM. The presence of airway reactivity before the development of asthma. Am Rev Respir Dis 1990 141: 2 8.
15. Henriksen AH, Sue-Chu M, Lingaas-Holman T, Langhammer A, Bjermer L. Exhaled and nasal NO levels in allergic rhinitis: relation to sensitization, pollen season and bronchial hyperresponsiveness. Eur Respir J 1999 13: 301 6.
16. Gratziou C, Robina N, Lignos M, Vogiatzis I, Roussos C. Exhaled nitric oxide in seasonal allergic rhinitis: influence of pollen season and therapy. Clin Exp Allergy 2001 31: 409 16.
17. Foresi A, Leone C, Pelucchi A et al. Eosinophils, mast cells, and basophils in induced sputum from patients with seasonal allergic rhinitis and perennial asthma: relationship to methacholine responsiveness. J Allergy Clin Immunol 1997 100: 58 64.
18. Djukanovic R, Lai CK, Wilson JW et al. Bronchial mucosal manifestations of atopy: a comparison of markers of inflammation between atopic asthmatics, atopic nonasthmatics and healthy controls. Eur Respir J 1992 5: 538 44.
19. Sterk PJ, Fabbri LM, Quanjer PH et al. Airway responsiveness. Standardised challenge testing with pharmacological, physical and sensitising stimuli in adults. Report working party standardisation of lung function tests, European Community for Steel and Coal. Official Statement of the European Respiratory society. Eur Respir J Suppl 1993 16: 53 83.
20. Global strategy for asthma management and prevention. Workshop report 2005.
21. Bousquet J. Allergic rhinitis and its impact on asthma (ARIA). Clin Exp Allergy Rev 2003 3: 43 5.
22. Britten KM, Howarth PH, Roche WR. Immunohistochemistry on resin sections: a comparison of resin embedding techniques for small mucosal biopsies. Biotech Histochem 1993 68: 271 80.
23. Sullivan P, Stephens D, Ansari T, Costello J, Jeffery P. Variation in the measurements of basement membrane thickness and inflammatory cell number in bronchial biopsies. Eur Respir J 1998 12: 811 5.
24. Salvi S, Semper A, Blomberg A et al. Interleukin 5 production by human epithelial cells. Am J Respir Cell Mol Biol 1999 20: 984 91.
25. Carlson M, Hakansson L, Peterson C, Stalenheim G, Venge P. Secretion of granule proteins from eosinophils and neutrophils is increased in asthma. J Allergy Clin Immunol 1991 87: 27 33.
26. Gauvreau GM, O'Bryne PM, Moqbel R et al. Enhanced expression of GM-CSF in differentiating eosinophils of atopic and atopic asthmatic subjects. Am J Respir Cell Mol Biol 1998 19: 55 62.
27. Lee NA, Gelfand EW, Lee JJ. Pulmonary T cells and eosinophils: coconspirators or independent triggers of allergic respiratory pathology? J Allergy Clin Immunol 2001 107: 945 57.
28. Louis R, Shute JK, Biagi S et al. Cell infiltration, ICAM-1 expression, and eosinophil chemotactic activity in asthmatic sputum. Am J Respir Crit Care Med 1997 155: 466 72.
29. Howarth PH, Wilson JW, Djuaknovic R et al. Airway inflammation and atopic asthma: a comparative bronchoscopic investigation. Int Arch Allergy Appl Immunol 1991 94: 266 9.
30. Braunstahl G-J, Fokkens WJ, Overbeck SE, KleinJan A, Hoogsteden HC, Prins JB. Mucosal and systemic inflammatory changes in allergic rhinitis and asthma: a comparison between upper and lower airways. Clin Exp Allergy 2003 33: 579 87.
31. Lam S, Al-Majed S, Chan H, Tse K, LeRiche JC, Chan-Yeung M. Differences in mediator release between allergic rhinitis and asthma. J Allergy Clin Immunol 1991 87: 842 9.
32. Alvarez MJ, Olaguibel JM, Garcia BE, Tabar AI, Urbiola E. Comparison of allergen-induced changes in bronchial hyperresponsiveness and airway inflammation between mildly allergic asthma patients and allergic rhinitis patients. Allergy 2000 55: 531 9.
33. Leckie MJ, ten Brinke A, Khan J et al. Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet 2000 356: 2144 8.
34. Djukanovic R, Wilson JW, Britten KM et al. Quantitation of mast cells and eosinophils in the bronchial mucosa of symptomatic atopic asthmatics and healthy control subjects using immunohistochemistry. Am Rev Respir Dis 1990 142: 863 71.
35. Wardlaw A, Dunnette S, Gleich G, Collins J, Kay AB. Eosinophils and mast cells in bronchoalveolar lavage in subjects with mild asthma. Relationship to bronchial hyperreactivity. Am Rev Respir Dis 1988 137: 62 9.
36. Kirby J, Hargreave F, Gleich G, O'Byrne P. Bronchoalveolar cell profiles of asthmatic and nonasthmatic subjects. Am Rev Respir Dis 1987 136: 379 83.
37. Beasley R, Roche WR, Roberts JA, Holgate ST. Cellular events in the bronchi in mild asthma and after bronchial provocation. Am Rev Respir Dis 1989 139: 806 17.
38. Bradley BL, Azzawi M, Jacobson M et al. Eosinophils, T-Lymphocytes, mast cells, neutrophils and macrophages in bronchial biopsy specimens from atopic subjects with asthma: comparison with biopsy specimens from atopic subjects without asthma and normal controls and relationship to hyperresponsiveness. J Allergy Clin Immunol 1991 88: 661 74.
39. Bradding P, Roberts JA, Britten KM et al. Interleukin-4, -5, and -6 and tumour necrosis factor-alpha in normal and asthmatic airways: evidence for the human mast cell as a source of these cytokines. Am J Respir Cell Mol Biol 1994 10: 471 80.
40. Bingham CO, Austen KF. Mast-cell responses in the development of asthma. J Allergy Clin Immunol 2000 105: S527 34.
41. Zangrilli JG, Shaver JR, Cirelli A et al. sVCAM-1 levels after segmental antigen challenge correlate with eosinophil influx, IL-4 and IL-5 production, and the late phase response. Am J Respir Crit Care Med 1995 151: 1346 53.
42. Leong KP, Huston DP. Understanding the pathogenesis of allergic asthma using mouse models. Ann Allergy Asthma Immunol 2001 87: 96 109.
43. Mishima H, Hojo M, Watanabe A, Hamod Q, Martin JG. CD4+ T cells can induce airway hyperresponsiveness to allergen challenge in the brown Norway rat. Am J Respir Crit Care Med 1998 158: 1863 70.
44. Huang TJ, MacAry PA, Kemeny DM, Chung KF. Effect of CD8+ T- cell depletion on bronchial hyper-responsiveness and inflammation in sensitized and allergen-exposed Brown-Norway rats. Immunology 1999 96: 416 23.
45. Stock P, Kallinich T, Akbari O et al. CD8(+) T cells regulate responses in a murine model of allergen-induced sensitisation and airway inflammation. Eur J Immunol 2004 34: 1817 27.
46. ten Hacken NH, Postma DS, Bosma F et al. Vascular adhesion molecules in nocturnal asthma: a possible role for VCAM-1 in ongoing airway wall inflammation. Clin Exp Allergy 1998 28: 1518 25.
47. Bentley AM, Durham SR, Robinson DS et al. Expression of endothelial and leukocyte adhesion molecules interacellular adhesion molecule-1, E-selectin, and vascular cell adhesion molecule-1 in the bronchial mucosa in steady-state and allergen-induced asthma. J Allergy Clin Immunol 1993 92: 857 68.
48. Chung KF, Barnes PJ. Cytokines in asthma. Thorax 1999 54: 825 57.
49. Borish L, Mascali JJ, Dishuck J, Beam WR, Martin RJ, Rosenwasser LJ. Detection of alveolar macrophage-derived IL-1 beta in asthma. Inhibition with corticosteroids. J Immunol 1992 149: 3078 82.
50. Sousa AR, Lane SJ, Nakhosteen JA, Lee TH, Poston RN. Expression of interleukin-1 beta (IL-1β) and interleukin receptor antagonist (IL-1ra) on bronchial asthmatic epithelium. Am J Respir Crit Care Med 1996 154: 1061 6.
51. Ying S, Robinson DS, Varney V et al. TNF alpha mRNA expression in allergic inflammation. Clin Exp Allergy 1991 21: 745 50.
52. Howarth PH, Babu S, Arshad HS et al. Tumour necrosis factor as a novel therapeutic target in symptomatic steroid dependant asthma. Thorax 2005 60: 1012 8.
53. Cembryznska-Nowak M, Szlarz E, Inglot AD, Teodorczyk-Injeyan JA. Elevated release of tumour necrosis factor-alpha and interferon-gamma by bronchoalveolar leukocytes from patients with bronchial asthma. Am Rev Respir Dis 1993 147: 291 5.
54. Krug N, Madden J, Redington AE et al. T-cell cytokine profile evaluated at the single cell level in BAL and blood in allergic asthma. Am J Respir Cell Mol Biol 1996 14: 319 26.
55. Krug N, Erpenback VJ, Balke K et al. Cytokine profile of bronchoalveolar lavage-derived CD4(+), CD8(+) and gamma delta T cells in people with asthma after segmental allergen challenge. Am J Respir Cell Mol Biol 2001 25: 125 31.
56. O'Sullivan S, Cormican JL, Ichinohe S, Johnston SL, Burke CM, Poulter LW. Activated, cytotoxic CD8+ T lymphocytes contribute to the pathology of asthma death. Am J Respir Crit Care Med 2001 164: 560 4.
57. Ying S, Durhma SR, Corrigan CJ, Hamid Q, Kay AB. Phenotype of cells expressing mRNA for TH2-type (interleukin 4 and interleukin 5) and TH1-type (interleukin 2 and interferon γ) cytokines in broncheoalveolar lavage and bronchial biopsies from atopic asthmatics and normal control subjects. Am J Respir Cell Mol Biol 1995 12: 477 87.
58. Suzuki M, Maghni K, Molet S, Shimbara A, Hamid QA, Martin JG. IFNγ secretion by CD8+ T cells inhibits allergen-induced airway eosinophilia but not late airway responses. J Allergy Clin Immunol 2002 109: 803 9.