Plasma level of thrombomodulin is an early indication of pancreatic necrosis in patients with acute pancreatitis

Internal Medicine

Volumn 46, Issue 8, 2007, Pages 441-446

  Lu, Xin Liang ^a   Cai, Jian Ting ^a   Lu, Xing Guo ^a   Si, Jian Min ^b   Qian, Ke Da ^a  

^a Department of Gastroenterology ^*  (China)

^b ZHEJIANG UNIVERSITY   (China)

Author keywords

Acute pancreatitis; Thrombomodulin

Indexed keywords

BIOLOGICAL MARKER; SOLUBLE THROMBOMODULIN; THROMBOMODULIN; UNCLASSIFIED DRUG;

ACUTE PANCREATITIS; ADULT; AGED; ALCOHOLIC PANCREATITIS; ARTICLE; CHOLELITHIASIS; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; CORRELATION COEFFICIENT; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; DISEASE ASSOCIATION; DISEASE CLASSIFICATION; DISEASE SEVERITY; EARLY DIAGNOSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PANCREAS NECROSIS; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; ROC CURVE;

ADULT; AGED; BIOLOGICAL MARKERS; EARLY DIAGNOSIS; FEMALE; HUMANS; MALE; MIDDLE AGED; NECROSIS; PANCREAS; PANCREATITIS, ACUTE NECROTIZING; PROSPECTIVE STUDIES; THROMBOMODULIN;

EID: 34247381104     PISSN: 09182918     EISSN: 13497235     Source Type: Journal    
DOI: 10.2169/internalmedicine.46.6320     Document Type: Article

References (17)

1. Working Party of the British Society of Gastroenterology, Association of Surgeons of Great Britain and Ireland, Pancreatic Society of Great Britain and Ireland, Association of Upper GI Surgeons of Great Britain and Ireland. UK guidelines for the management of acute pancreatitis. Gut 54 Suppl 3: iii1-iii9, 2005.
2. Werner J, Hartwig W, Uhl W, Muller C, Buchler MW. Useful markers for predicting severity and monitoring progression of acute pancreatitis. Pancreatology 3: 115-127, 2003.
3. Hirota M, Takada T, Kawarada Y, et al. JPN Guidelines for the management of acute pancreatitis: severity assessment of acute pancreatitis. J Hepatobiliary Pancreat Surg 13: 33-41, 2006.
4. Matull WR, Pereira SP, O'Donohue JW. Biochemical markers of acute pancreatitis. J Clin Pathol 59: 340-344, 2006.
5. Van d Wouwere M, Conway EM. Novel functions of thrombo-modulin in inflammation. Crit Care Med 32: S254-S261, 2004.
6. Boehme MW, Autschbach F, Zuna I, et al. Elevated serum levels and reduced immunohistochemical expression of thrombomodulin in active ulcerative colitis. Gastroenterology 113: 107-117, 1997.
7. Boldt J, Wollbruck T, Sonneborn S, Welters A, Hempelmann G. Thrombomodulin in intensive care patients. Intensive Care Med 21: 645-650, 1995.
8. Iba T, Yagi Y, Kidokoro A, Fukunaga M, Fukunaga T. Increased plasma levels of soluble thrombomodulin in patients with sepsis and organ failure. Surg Today 25: 585-590, 1995.
9. Ikegami K, Suzuki Y, Yukioka T, Matsuda H, Shimazaki S. Endothelial cell injury, as quantified by the soluble thrombomodulin level, predicts sepsis/multiple organ dysfunction syndrome after blunt trauma. J Trauma 44: 789-794, 1998.
10. Takano S, Kimura S, Ohdama S, Aoki N. Plasma thrombomodulin in health and diseases. Blood 76: 2024-2029, 1990.
11. Gando S, Kameue T, Nanzaki S, Nakanishi Y. Cytokines, soluble thrombomodulin and disseminated intravascular coagulation in patients with systemic inflammatory response syndrome. Thromb Res 80: 519-526, 1995.
12. Krafte-Jacobs B, Brilli R. Increased circulating thrombomodulin in children with septic shock. Crit Care Med 26: 933-938, 1998.
13. Wada H, Mori Y, Shimura M, et al. Poor outcome in disseminated intravascular coagulation or thrombotic thrombocytopenic purpura patients with severe vascular endothelial cell injuries. Am J Hematol 58: 189-194, 1998.
14. Bradley EL 3rd. A clinically based classification system for acute pancreatitis. Summary of the International Symposium on Acute Pancreatitis, Atlanta, Ga, September 11 through 13, 1992. Arch Surg 128: 586-590, 1993.
15. Balthazar EJ, Robinson DL, Megibow AJ, Ranson JH. Acute pancreatitis: value of CT in establishing prognosis. Radiology 174: 331-336, 1990.
16. Balthazar EJ. Acute pancreatitis: assessment of severity with clinical and CT evaluation. Radiology 223: 603-613, 2002.
17. Toh SK, Phillips S, Johnson CD. A prospective audit against national standards of the presentation and management of acute pancreatitis in the South of England. Gut 46: 239-243, 2000.