Edaravone, a radical scavenger, inhibits mitochondrial permeability transition pore in rat brain

Journal of Pharmacological Sciences

Volumn 103, Issue 4, 2007, Pages 434-437

  Takayasu, Yuko ^a   Nakaki, Junko ^a   Kawasaki, Toshiyuki ^a   Koda, Ken ^a   Ago, Yukio ^a   Baba, Akemichi ^a   Matsuda, Toshio ^a  

^a OSAKA UNIVERSITY   (Japan)

Author keywords

Edaravone; Permeability transition pore (PTP); Reactive oxygen species (ROS)

Indexed keywords

CALCIUM; HYDROGEN PEROXIDE; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; NORPHENAZONE; REACTIVE OXYGEN METABOLITE;

ANIMAL TISSUE; ARTICLE; BRAIN MITOCHONDRION; CONTROLLED STUDY; DRUG INHIBITION; FLUORESCENCE ANALYSIS; MALE; MITOCHONDRIAL PERMEABILITY; MITOCHONDRION SWELLING; NONHUMAN; RAT;

EID: 34247368958     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.SC0070014     Document Type: Article

References (13)

1. The Edaravone Acute Brain Infarction Study Group. Effect of a novel free radical scavenger, edaravone (MCI-186), on acute brain infarction. Cerebrovasc Dis. 2003;15:222-229.
2. Watanabe T, Yuki S, Egawa M, Nishi H. Protective effects of MCI-186 on cerebral ischemia: possible involvement of free radical scavenging and antioxidant action. J Pharmacol Exp Ther. 1994;268:1597-1604.
3. Minhaz U, Tanaka M, Tsukamoto H, Watanabe K, Koide S, Shohtsu A, et al. Effect of MCI-186 on postischemic reperfusion injury in isolated rat heart. Free Radic Res. 1996;24:361-367.
4. Okatani Y, Wakatsuki A, Enzan H, Miyahara Y. Edaravone protects against ischemia/reperfusion-induced oxidative damage to mitochondria in rat liver. Eur J Pharmacol. 2003;465:163-170.
5. Takuma K, Phuagphong P, Lee E, Mori K, Baba A, Matsuda T. Anti-apoptotic effect of cGMP in cultured astrocytes: inhibition by cGMP-dependent protein kinase of mitochondrial permeable transition pore. J Biol Chem. 2001;276:48093-48099.
6. Takuma K, Baba A, Matsuda T. Astrocyte apoptosis: implications for neuroprotection. Prog Neurobiol. 2004;72:111-127.
7. Rajesh KG, Sasaguri S, Suzuki R, Maeda H. Antioxidant MCI-186 inhibits mitochondrial permeability transition pore and upregulates Bcl-2 expression. Am J Physiol Heart Circ Physiol. 2003;285:H2171-H2178.
8. Brustovetsky N, Dubinsky JM. Limitations of cyclosporin A inhibition of the permeability transition in CNS mitochondria. J Neurosci. 2000;20:8229-8237.
9. Panov AV, Andreeva L, Greenamyre JT. Quantitative evaluation of the effects of mitochondrial permeability transition pore modifiers on accumulation of calcium phosphate: comparison of rat liver and brain mitochondria. Arch Biochem Biophys. 2004;424:44-52.
10. Sims NR. Rapid isolation of metabolically active mitochondria from rat brain and subregions using Percoll density gradient centrifugation. J Neurochem. 1990;55:698-707.
11. Fukushima T, Koide M, Ago Y, Baba A, Matsuda T. T-817MA, a novel neurotrophic agent, improves sodium nitroprusside-induced mitochondrial dysfunction in cortical neurons. Neurochem Int. 2006;48:124-130.
12. Suleiman M, Halestrap AP, Griffiths EJ. Mitochondria: a target for myocardial protection. Pharmacol Ther. 2001;89:29-76.
13. Takayasu Y, Fukushima T, Takegawa Y, Fujisaki H, Koyama Y, Baba A, et al. Effect of edaravone on mitochondrial permeability transition pore in isolated rat brain mitochondria. J Pharmacol Sci. 2005;97 Suppl I:215P.