Optical biosensor based on silicon-on-insulator microring cavities for specific protein binding detection

Progress in Biomedical Optics and Imaging - Proceedings of SPIE

Volumn 6447, Issue , 2007, Pages

  De Vos, Katrien M ^a   Bartolozzi, Irene ^b   Bienstman, Peter ^a   Baets, Roel ^a   Schacht, Etienne ^b  

^a Photonics Research Group   (Belgium)

^b Polymer Chemistry and Biomaterials Research Group   (Belgium)

Author keywords

Avidin biotin; Label free detection; Microring resonator; Optical biosensor; Protein interaction; Silicon on insulator

Indexed keywords

LITHOGRAPHY; OPTICAL SYSTEMS; PARAMETER ESTIMATION; PROTEINS; REAL TIME SYSTEMS; SILICON ON INSULATOR TECHNOLOGY;

AVIDIN/BIOTIN; LABEL FREE DETECTION; MICRORING RESONATORS; OPTICAL BIOSENSORS; PROTEIN INTERACTION;

BIOSENSORS;

EID: 34247366374     PISSN: 16057422     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1117/12.698875     Document Type: Conference Paper

References (20)

1. Čtyrocký J., Homola J., Lambeck P.V., Musa S., Hoekstra H.J.W.M., Harris R.D., Wilkinson J.S., Usievich B., Lyndin N.M., "A Surface Plasmon Resonance Based Integrated Optical Sensor", Sens. Actuators B, 54, 66-73, 1999.
2. Homola J., "Present and Future of Surface Plasmon Resonance Biosensors", Anal. Bioanal. Chem., 377, 528-539, 2003.
3. Lukosz W., "Principles and Sensitivities of Integrated Optical and Surface Plasmon Sensors for Direct Affinity Sensing and Immunosensing", Biosensors & Bioelectronics, 6, 215-225, 1991.
4. Brandenburg, A., "Differential refractometry by an integrated-optical Young interferometer", Sens. Actuators B, 38-39, 266-271, 1997.
5. Hradetzky D., Mueller C., Reinecke H., "Interferometric Label-free Biomolecular Detection System", J. Opt. A: Pure Appl. Opt., 8, S360-S364, 2006.
6. Ymeti A., Kanger J.S., Greve J., Besselink G.A.J., Lambeck P.V., Wijn R., Heideman R.G., "Integration of Microfluidics with a Four-channel Integrated Optical Young Interferometer Immunosensor", Biosensors and Bioelectronics, 20, 1417-1421, 2005.
7. Boyd R.W., Heebner J.E.,. "Sensitive Disk Resonator Photonic Biosensor", Applied Optics, 40, 5742-5747, 2001.
8. Chao C-Y., Fung W., Guo L.J., "Polymer Microring Resonators for Biochemical Sensing Applications", IEEE J. Sel. Topics Quantum Electron., 12, 134-142, 2006.
9. Ksendzov A., Lin Y., "Integrated Optics Ring-resonator Sensors for Protein Detection", Opt. Lett., 30, 3344-3346, 2005.
10. Yalçin A. Popat K.C., Aldridge J.C., Desai T.A. Hryniewicz J., Chbouki N., Little B.E., King O., Van V., Chu S., Gill D., Anthes-Washburn M., Ünlü M.S., Goldberg B.B., "Optical Sensing of Biomolecules Using Microring Resonators", IEEE J. Sel. Topics Quantum Electron., 12, 148-155, 2006.
11. Orth R.N., Clark T.G., Craighead H.G., "Avidin-Biotin Micropatteming Methods for Biosensor Applications", Biomedical Microdevices, 5, 29-34, 2003.
12. Schwelb O., "Transmission, Group Delay and Dispersion in Single-Ring Optical Resonators and Add/Drop Filters - A Tutorial Overview", J. Lightwave Technology, 22(5),1380-1394, 2004.
13. Chao C-Y., Guo L.J., "Design and Optimization of Microring Resonators in Biochemical Sensing Applications", J Lightwave Technology, 24, 1395-1402, 2006.
14. Krioukov E., Greve J., Otto C., "Performance of Integrated Optical Microcavities for Refractive Index and Fluorescence Sensing", Sensors and Actuators B, 90, 58-67, 2003.
15. Bogaerts W., Baets R., Dumon P., Wiaux V., Beckx S., Taillaert D., Luyssaert B., Van Campenhout J., Bienstman P., Van Tourhout D., "Nanophotonic Waveguides in Silicon-on-Insulator Fabricated with CMOS Technology", J. Lightwave Technology, 23, 401-412, 2005.
16. Zhang F., Srinivasan M.P., "Self-Assembly Molecular Films of Aminosilanes and their Immobilization Capacities", Langmuir, 20, 2309-2314, 2004.
17. Schreiber F., "Self-Assembled Monolayers: from 'Simple' Model Systems to Biofunctionalized Interfaces", J. Phys.: Condens. Matter, 16, R881-R900, 2004.
18. Vörös J., "The Density and Refractive Index of Adsorbing Protein Layers", Biophysical Journal, 87, 553-561, 2004.
19. Lyde D.R., Handbook of Chemistry and Physics, 77th ed., CRC press, London, 1997-1998.
20. www.biacore.com, application note 48.