An in vitro cytologic assay for evaluation of the KIT signaling pathway in gastrointestinal stromal tumors

Modern Pathology

Volumn 20, Issue 5, 2007, Pages 579-583

  Chang, Brian S ^a   Yang, Tao ^a   Cibas, Edmund S ^a   Fletcher, Jonathan A ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Cytology; Gastrointestinal stromal tumor; Imatinib; Immunocytochemistry; KIT pathway; Tyrosine kinase

Indexed keywords

EVEROLIMUS; IMATINIB; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; PROTEIN ANTIBODY; PROTEIN KINASE B; PROTEIN S6; STEM CELL FACTOR;

ACCURACY; ARTICLE; CANCER CELL CULTURE; CANCER SUSCEPTIBILITY; CELL ASSAY; CONTROLLED STUDY; CYTOLOGY; GASTROINTESTINAL STROMAL TUMOR; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

CELL LINE, TUMOR; CYTOLOGICAL TECHNIQUES; DRUG RESISTANCE, NEOPLASM; EVALUATION STUDIES; GASTROINTESTINAL STROMAL TUMORS; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSIVE AGENTS; PIPERAZINES; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-KIT; PYRIMIDINES; SENSITIVITY AND SPECIFICITY; SIGNAL TRANSDUCTION; SIROLIMUS;

EID: 34247359176     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.3800779     Document Type: Article

References (2)

1. Eisenberg BL. Imatinib mesylate: a molecularly targeted therapy for gastrointestinal stromal tumors. Oncology 2003;17:1615-1620.
2. Duensing A, Medeiros F, McConarty B, et al. Mechanisms of oncogenic KIT signal transduction in primary gastrointestinal stromal tumors (GISTs). Oncogene 2004;23:3999-4006.