Computational thermal analysis of a continuous flow micro Polymerase Chain Reaction (PCR) chip

Proceedings of SPIE - The International Society for Optical Engineering

Volumn 6415, Issue , 2007, Pages

  Sugumar, D ^a   Ashraf, Muhammad A ^a   Kong, L X ^a  

^a UNIVERSITY OF SOUTH AUSTRALIA   (Australia)

Author keywords

MEMS; Microchannel; Microfluidic; PCR; Thermal heating

Indexed keywords

AMPLIFICATION; COMPUTER SOFTWARE; DNA SEQUENCES; FINITE ELEMENT METHOD; MEMS; MICROCHANNELS; MICROFLUIDICS; MOLECULAR BIOLOGY; THERMAL GRADIENTS; THERMOANALYSIS; THERMODYNAMIC PROPERTIES;

FINITE ELEMENT SOFTWARE; MICRO CHAMBERS; POLYMERASE CHAIN REACTION (PCR); THERMAL HEATING;

BIOCHIPS;

EID: 34247355533     PISSN: 0277786X     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1117/12.695655     Document Type: Conference Paper

References (12)

1. Mullis, K., Faloona F, Scharf S, Saiki R, Horn G, Erlich H., Specific enzymatic amplification of DNA in vitro: the polymerase chain reaction. Cold Spring Harb Symp Quant Biol., 1986. 51: p. 263-273.
2. Ehrlich, D.J. and P. Matsudaira, Microfluidic devices for DNA analysis. Trends in Biotechnology, 17(8), 315 (1999).
3. Mullis, K.B., F. Ferre, and R.A. Gibbs, The Polymerase chain reaction ed. J.D. Watson. 1994, Boston: Birkhauser.
4. Bartlett, J.M.S. and D. Stirling, PCR protocols. 2 ed. 2003, New Jersey: Humana Press.
5. Demello, A.J., DNA amplification moves on. Nature, 422, 28-29 (2003).
6. Mello, A.J.d., DNA amplification: does small really mean efficient? Lab on Chip, 1, 24-29 (2001).
7. Northrup, M.A., et al. A Mems-based Miniature DNA Analysis System, in The 8th International Conference on Solid-State Sensors and Actuators, 1995 and Eurosensors IX. Transducers '95. . 1995.
8. Anderson, R.C., et al., A miniature integrated device for automated multistep genetic assays. Nucl. Acids Res., 28(12), e60 (2000).
9. Lagally, E., I. Medintz, and M. RA, Single-Molecule DNA Amplification and Analysis in an Integrated Microfluidic Device. Anal. Biochem, (73), 565-570 (2001).
10. Martin U. Kopp, A.J.d.M., Andreas Manz, Chemical Amplification: Continuous-Flow PCR on a Chip. Science, 280, 1046-1048 (1998).
11. Chiou, J., et al., A Closed-Cycle Capillary Polymerase Chain Reaction Machine. Anal. Chem., 73(9), 2018-2021 (2001).
12. Nakano H, M.K., Yohda M, Nagamune T, Endo I, Yamane T., High speed polymerase chain reaction in constant flow. Biosci Biotechnol Biochem., 58(2), 349-352 (1994).