ANTINEOPLASTIC ACTIVITY;
ARTICLE;
BIOLOGICAL ACTIVITY;
CANCER CELL CULTURE;
CYCLOADDITION;
DRUG SYNTHESIS;
HUMAN;
HUMAN CELL;
IN VITRO STUDY;
IN VIVO STUDY;
POLYMERIZATION;
Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase inhibitors and antitumor agents: Synthesis and biological activities of 2,4-diamino-5-methyl-6-[(monosubstituted- anilino)-methyl] - pyrido[2,3-d]pyrimidines
Gangjee A, Aldair O, Queener S F. Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase inhibitors and antitumor agents: synthesis and biological activities of 2,4-diamino-5-methyl-6-[(monosubstituted- anilino)-methyl] - pyrido[2,3-d]pyrimidines. J. Med. Chem. 1999; 42(13): 2447-2455.
(1999)J. Med. Chem, vol.42, Issue.13, pp. 2447-2455
Synthesis of antitumor activity of 2,4-diamino-6-(2,5-dimethoxy-benzyl)-5-methylpyrido[2,3- d]pyrimidine
Grivsky E M, Lee S; Sigel C W, Duch D S, Nichol C A. Synthesis of antitumor activity of 2,4-diamino-6-(2,5-dimethoxy-benzyl)-5-methylpyrido[2,3- d]pyrimidine. J. Med. Chem. 1980; 23(3): 327-329.
Furuya S, Ohtaki T. Pyrido[2,3-d]pyrimidines and their use as endothelin anatagonists. Eur. Pat. Appl. Ep. 608565, 1994; Chem. Abstr. 1994; 121: 205395w
Furuya S, Ohtaki T. Pyrido[2,3-d]pyrimidines and their use as endothelin anatagonists. Eur. Pat. Appl. Ep. 608565, 1994; Chem. Abstr. 1994; 121: 205395w.
4
0027248862
Heber D, Heers C, Ravens U. Positive inotropic activity of 5-amino-6-cyano-1,3-dimethyl-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-2, 4-dione in cardiac muscle from guinea pig and man. Part 6: compounds with positive inotropic activity. Pharmazie 1993; 48(7): 537-541.
Heber D, Heers C, Ravens U. Positive inotropic activity of 5-amino-6-cyano-1,3-dimethyl-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-2, 4-dione in cardiac muscle from guinea pig and man. Part 6: compounds with positive inotropic activity. Pharmazie 1993; 48(7): 537-541.
5
0342487060
Preparation of bicyclic pyrimidine derivatives and pharmaceutical compositions containing them for treatment of hypoxemia. PCT Int. Appl. WO 91 05,785, 1989
Sakuma Y, Hasegawa M, Kataoka K, Hoshina K, Yamazaki N, Kadota T, Yamaguchi H. Preparation of bicyclic pyrimidine derivatives and pharmaceutical compositions containing them for treatment of hypoxemia. PCT Int. Appl. WO 91 05,785, 1989; Chem. Abstr. 1991; 115: 71646u.
Synthesis and antimicrobial evaluation of some new pyrido[2,3-d] pyrimidines and their riboufuranosides
Singh G, Singh G, Yadav A K, Mishraa K. Synthesis and antimicrobial evaluation of some new pyrido[2,3-d] pyrimidines and their riboufuranosides. Ind. J. Chem. 2002; 41(2): 430-432.
Zakharov A V, Gavrilov M Yu, Demina L M, Novoselova G N, Gornova N A, Konshin M Ye. Derivatives of 1-aryl-2-vinylpyrido[2,3-d]pyrimidine-4- ones: synthesis and antimicrobial activity. Kim.-Farm. Zh. 1994; 28(11): 24-26. Chem. Abstr. 1996; 124: 29692s.
Zakharov A V, Gavrilov M Yu, Demina L M, Novoselova G N, Gornova N A, Konshin M Ye. Derivatives of 1-aryl-2-vinylpyrido[2,3-d]pyrimidine-4- ones: synthesis and antimicrobial activity. Kim.-Farm. Zh. 1994; 28(11): 24-26. Chem. Abstr. 1996; 124: 29692s.
8
0026530765
Synthesis and antifolate properties of 5,10-ethano-5,10-dideaza-aminoprotein
DeGraw J I, Christie P H, Clowell W T, Sirotnak F M. Synthesis and antifolate properties of 5,10-ethano-5,10-dideaza-aminoprotein. J. Med. Chem. 1992; 35(2): 320-324.
Katritzky A R, Rees C W, Eds. In: Comperhensive Heterocyclic Chemistry, (Boulton A. J.; McKillop A., Eds.), 3, Pergamon Press, Oxford, 1984: 129-261..
Katritzky A R, Rees C W, Eds. In: Comperhensive Heterocyclic Chemistry, (Boulton A. J.; McKillop A., Eds.), Volume 3, Pergamon Press, Oxford, 1984: 129-261..
10
0000539184
A regioselective synthesis of pyrrolo- and pyrido[2,3-d]pyrimidine-2,4-diones
Tamura G, Sakaguchi T, Kawasaki T, Kita Y. A regioselective synthesis of pyrrolo- and pyrido[2,3-d]pyrimidine-2,4-diones. Heterocycles 1975; 3(2): 183-186.
Synthesis of pyrido[2,3-d]pyrimidine by reaction of aminopyrimidine-4-one with benzylidene meldrum's acid derivatives
Quiroga J, Hormaza A, Insuasty B, Nogueras M, Sánchez A., Hanold N, Meier H. Synthesis of pyrido[2,3-d]pyrimidine by reaction of aminopyrimidine-4-one with benzylidene meldrum's acid derivatives. J. Heterocycl. Chem. 1997; 34: 521-524.
An elegant approach towards the regioselective synthesis of deazalumazines through nucleophilic induced ring transformation reactions of 6-aryl-3-cyano-4-methylthio-2H-pyran-2-one
Srivastava P, Saxena A S, Ram V J. An elegant approach towards the regioselective synthesis of deazalumazines through nucleophilic induced ring transformation reactions of 6-aryl-3-cyano-4-methylthio-2H-pyran-2-one. Synthesis 2000: 541-544.
Pyrido[2,3-d]pyrimidines. IV. Synthetic studies leading to various oxopyrido[2,3-d]pyrimidines
Broom A D, Shim J L, Anderson G L. Pyrido[2,3-d]pyrimidines. IV. Synthetic studies leading to various oxopyrido[2,3-d]pyrimidines. J. Org. Chem. 1976; 41(7): 1095-1099.
(1976)J. Org. Chem, vol.41, Issue.7, pp. 1095-1099
A novel three-component one-pot synthesis of pyrano[2,3-d] pyrimidines and pyrido[2,3-d] pyrimidines using microwave heating in the solid state
Devi I, Kumar B S D, Bhuyan P J. A novel three-component one-pot synthesis of pyrano[2,3-d] pyrimidines and pyrido[2,3-d] pyrimidines using microwave heating in the solid state. Tetrahedron Lett. 2003, 44(45): 8307-8310.
New aspects on the selective synthesis of 7-arylpyrido[2,3-d] pyrimidines
Quiroga J, Insuasty H, Insuasty B, Abonia R, Cobo J, Sánchez A, Nogueras M. New aspects on the selective synthesis of 7-arylpyrido[2,3-d] pyrimidines. Tetrahedron 2002; 58(24): 4873-4877.
(2002)Tetrahedron, vol.58, Issue.24, pp. 4873-4877
Antibacterial and antifungal activity of nine medical plants from Zaire
Muanza D N, Kim B W, Euler K L, Williams L. Antibacterial and antifungal activity of nine medical plants from Zaire. International J. Pharmacog. 1994; 32: 337-345.
Yshihisa M, Tohru U, Michikok K, Yuzuru S, Toshitaka M. Synthetic studies of nucleic acid-purines and related compounds. I. Synthesis of hypoxanthine. Yakugaku Zasshi 1957; 77: 680-688. Chem. Abstr. 1957 ;51: 16494c.
Yshihisa M, Tohru U, Michikok K, Yuzuru S, Toshitaka M. Synthetic studies of nucleic acid-purines and related compounds. I. Synthesis of hypoxanthine. Yakugaku Zasshi 1957; 77: 680-688. Chem. Abstr. 1957 ;51: 16494c.
23
0033911007
Studies with functionally substituted heteroaromatics: The chemistry of N-phenylhydrazonylalkylpyridinium salts and of phenylhydazonyl-alkylbenzoazoles
Abdel-Khalik M M, Elnagdi M H, Agamy S M. Studies with functionally substituted heteroaromatics: the chemistry of N-phenylhydrazonylalkylpyridinium salts and of phenylhydazonyl-alkylbenzoazoles. Synthesis 2000; 1166-1169.
Pretsch E, Simon W, Seibl J, Clerc T. In : Tables of spectral data for determination of organic compounds. Springer-Verlag, Berlin, 2nd Edition. 1989: 320.