Successful treatment of multiple hepatocellular carcinoma with tumor thrombi in the major portal branches by intraarterial 5-fluorouracil perfusion chemotherapy combined with subcutaneous interferon-alpha and hepatectomy

International Journal of Clinical Oncology

Volumn 12, Issue 2, 2007, Pages 150-154

  Yamamoto, Tameyoshi ^a   Nagano, Hiroaki ^a   Imai, Yasuharu ^b   Fukuda, Kazuto ^b   Matsumoto, Hitoshi ^b   Kondo, Motoi ^a   Ota, Hideo ^a   Nakamura, Masato ^a   Wada, Hiroshi ^a   Noda, Takehiro ^a   Damdinsuren, Bazarragchaa ^a   Dono, Keizo ^a   Umeshita, Koji ^a   Nakamori, Shoji ^a   Sakon, Masato ^a   Wakasa, Kenichi ^c   Monden, Morito ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b Ikeda Municipal Hospital   (Japan)

^c OSAKA CITY UNIVERSITY HOSPITAL   (Japan)

Author keywords

Chemotherapy; Hepatectomy; Hepatocellular carcinoma; Interferon; Portal vein tumor thrombi

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA FETOPROTEIN; ALPHA INTERFERON; ASPARTATE AMINOTRANSFERASE; FLUOROURACIL; INDOCYANINE GREEN; TUMOR MARKER; VITAMIN K GROUP;

ADULT; ARTICLE; BILIRUBIN BLOOD LEVEL; CANCER CHEMOTHERAPY; CASE REPORT; COMPUTER ASSISTED TOMOGRAPHY; CONTINUOUS INFUSION; DIAGNOSTIC IMAGING; DISEASE COURSE; DISEASE MARKER; HEPATITIS C; HEPATITIS C VIRUS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LIVER CELL CARCINOMA; LIVER METASTASIS; LIVER RESECTION; MALE; MULTIPLE CANCER; MULTIPLE CYCLE TREATMENT; NUCLEAR MAGNETIC RESONANCE IMAGING; PARTIAL HEPATECTOMY; PORTAL VEIN THROMBOSIS; PRIORITY JOURNAL; PROTHROMBIN TIME; RECURRENT CANCER; THROMBECTOMY; TREATMENT OUTCOME;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CARCINOMA, HEPATOCELLULAR; FLUOROURACIL; HEPATECTOMY; HUMANS; INFUSIONS, INTRA-ARTERIAL; INJECTIONS, SUBCUTANEOUS; INTERFERON-ALPHA; LIVER NEOPLASMS; MALE; MIDDLE AGED; NEOADJUVANT THERAPY; NEOPLASM CIRCULATING CELLS; PERFUSION; PORTAL VEIN; TREATMENT OUTCOME; VENOUS THROMBOSIS;

EID: 34247340531     PISSN: 13419625     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10147-006-0630-1     Document Type: Article

References (21)

1. DG Farmer MH Rosove A Shaked 1994 Current treatment modalities for hepatocellular carcinoma Ann Surg 219 236 247
2. AS Befeler AM Di Bisceglie 2002 Hepatocellular carcinoma: diagnosis and treatment Gastroenterology 122 1609 1619
3. CC Barnett SA Curley 2001 Ablative techniques for hepatocellular carcinoma Semin Oncol 28 487 496
4. T Fujii K Takayasu Y Muramatsu 1993 Hepatocellular carcinoma with portal tumor thrombus: analysis of factors determining prognosis Jpn J Clin Oncol 23 105 109
5. I Ikai Y Yamaoka Y Yamamoto 1998 Surgical intervention for patients with stage IV-A hepatocellular carcinoma without lymph node metastasis: proposal as a standard therapy Ann Surg 227 433 439
6. J Fan ZQ Wu ZY Tang 2001 Multimodality treatment in hepatocellular carcinoma patients with tumor thrombi in portal vein World J Gastroenterol 7 28 32
7. JM Llovet J Bustamante A Castells 1999 Natural history of untreated nonsurgical hepatocellular carcinoma: rationale for the design and evaluation of therapeutic trials Hepatology 29 62 67
8. RT Poon ST Fan IO Ng 2003 Prognosis after hepatic resection for stage IVA hepatocellular carcinoma: a need for reclassification Ann Surg 237 376 383
9. M Sakon H Nagano K Dono 2002 Combined intraarterial 5-fluorouracil and subcutaneous interferon-alpha therapy for advanced hepatocellular carcinoma with tumor thrombi in the major portal branches Cancer 94 435 442
10. H Ota H Nagano M Sakon 2005 Treatment of hepatocellular carcinoma with major portal vein thrombosis by combination of subcutaneous interferon-α and intraarterial 5-fluorouracil: role of expression of type 1 interferon receptor Br J Cancer 93 557 564
11. Nagano H, Sakon M, Eguchi H, et al. Hepatic resection followed by IFN-α and 5-FU for advanced hepatocellular carcinoma with tumor thrombus in the major portal branch. Hepatogastroenterology (in press)
12. T Itamoto H Nakahara H Tashiro 2002 Hepatic arterial infusion of 5-fluorouracil and cisplatin for unresectable or recurrent hepatocellular carcinoma with tumor thrombus of the portal vein J Surg Oncol 80 143 148
13. DW Shen YG Lu KV Chin 1991 Human hepatocellular carcinoma cell lines exhibit multidrug resistance unrelated to MRD1 gene expression J Cell Sci 98 317 322
14. T Urabe S Kaneko E Matsushita 1998 Clinical pilot study of intrahepatic arterial chemotherapy with methotrexate, 5-fluorouracil, cisplatin and subcutaneous interferon-alpha-2b for patients with locally advanced hepatocellular carcinoma Oncology 55 39 47
15. YZ Patt MM Hassan RD Lozano 2003 Phase II trial of systemic continuous fluorouracil and subcutaneous recombinant interferon Alfa-2b for treatment of hepatocellular carcinoma J Clin Oncol 21 421 427
16. EL Schwartz M Hoffman CJ O'Connor 1992 Stimulation of 5-fluorouracil metabolic activation by interferon-alpha in human colon carcinoma cells Biochem Biophys Res Commun 182 1232 1239
17. CL van der Wilt K Smid GW Aherne 1997 Biochemical mechanisms of interferon modulation of 5-fluorouracil activity in colon cancer cells Eur J Cancer 33 471 478
18. H Eguchi H Nagano H Yamamoto 2000 Augmentation of antitumor activity of 5-fluorouracil by interferon alpha is associated with up-regulation of p27Kip1 in human hepatocellular carcinoma cells Clin Cancer Res 6 2881 2890
19. T Yamamoto H Nagano M Sakon 2004 Partial contribution of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)/TRAIL receptor pathway to antitumor effects of interferon-alpha/5-fluorouracil against hepatocellular carcinoma Clin Cancer Res 10 7884 7895
20. M Kondo H Nagano H Wada 2005 Combination of IFN-alpha and 5-fluorouracil induces apoptosis through IFN-alpha/beta receptor in human hepatocellular carcinoma cells Clin Cancer Res 11 1277 1286
21. M Kondo H Nagano M Sakon 2000 Expression of interferon alpha/beta receptor in human hepatocellular carcinoma Int J Oncol 17 83 88