Antibody gene therapy: An attractive approach for the treatment of cancers and other chronic diseases

Cell Research

Volumn 17, Issue 4, 2007, Pages 303-306

  Zheng, Dexian ^a  

^a INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MONOCLONAL ANTIBODY; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND RECEPTOR; UNCLASSIFIED DRUG;

ADENO ASSOCIATED VIRUS; ANIMAL; APOPTOSIS; AUTOPHAGY; CHRONIC DISEASE; ENZYME ACTIVATION; GENE THERAPY; GENE VECTOR; GENETICS; HUMAN; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOLOGY; METABOLISM; MOUSE; NEOPLASM; NOTE; SIGNAL TRANSDUCTION; TUMOR CELL LINE; XENOGRAFT;

ANIMALS; ANTIBODIES, MONOCLONAL; APOPTOSIS; AUTOPHAGY; CASPASES; CELL LINE, TUMOR; CHRONIC DISEASE; DEPENDOVIRUS; ENZYME ACTIVATION; GENE THERAPY; GENETIC VECTORS; HUMANS; IMMUNOGLOBULIN VARIABLE REGION; MICE; NEOPLASMS; NF-KAPPA B; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; SIGNAL TRANSDUCTION; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TRANSPLANTATION, HETEROLOGOUS;

EID: 34247332617     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/cr.2007.13     Document Type: Note

References (9)

1. Shi J, Liu YX, Zheng Y, et al. Therapeutic expression of an anti-death receptor 5 single-chain fixed-variable region prevents tumor growth in mice, Cancer Res 2006; 66:11946-11953
2. Chaudhary PM, Eby M, Jasmin A, Bookwalter A, Murray J, Hood L. Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-κB pathway. Immunity 1997; 7: 821-830.
3. Guo YB, Zhang JC, Zheng Y, et al. A novel anti-human DR5 monoclonal antibody with tumoricidal activity induces caspase-dependent and caspase-independent cell death. J Biol Chem 2005; 280:41940-41952.
4. Jain RK. Vascular and interstitial barriers to delivery of therapeutic agents in tumors. Cancer Metast Rev 1990; 9:253-266.
5. Fukuchi KI, Tahara K, Kim HD, et al. Anti-Aβ single-chain antibody delivery via adeno-associated virus for treatment of Alzheimer's disease, Neurobiol Dis 2006; 23:502-511.
6. Levites Y, Jansen K, Smithson LA, et al. Intracranial adeno-associated virus-mediated delivery of anti-pan amyloid β, amyloid β40, and amyloid β42 single-chain variable fragments attenuates plaque pathology in amyloid precursor protein mice. J Neurosci 2006; 26:11923-11928.
7. Passini MA, Watson DJ, Vite CH, Landsburg DJ, Feigenbaum AL, Wolfe JH. Intraventricular brain injection of adeno-associated virus type 1 (AAV1) in neonatal mice results in complementary patterns of neuronal transduction to AAV2 and total long-term correction of storage lesions in the brains of beta-glucuronidase-deficient mice. J Virol 2003; 77:7034-7040.
8. Ye ZM, Hellström I, Hayden-Ledbetter M, Dahlin A, Ledbetter JA, Hellström KE. Gene therapy for cancer using single-chain Fv fragments specific for 4-1BB. Nat Med 2002; 8:343-348.
9. Fang JM, Qian JJ, Yi SL, et al. Stable antibody expression at therapeutic levels using the 2A peptide. Nat Biotechnol 2005; 23:584-590.