Secretion of total pepsin and pepsin 1 in healthy volunteers in response to pentagastrin and to insulin-induced hypoglycaemia

Scandinavian Journal of Gastroenterology

Volumn 42, Issue 5, 2007, Pages 555-561

  Roberts, Norman Bryson ^a   Sheers, Roger ^b   Taylor, William Halstead ^a  

^a ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST   (United Kingdom)

^b GLAN CLWYD HOSPITAL   (United Kingdom)

Author keywords

Gastric secretion; Insulin hypoglycaemia; Pentagastrin; Pepsin 1

Indexed keywords

INSULIN; PENTAGASTRIN; PEPSIN A;

ADULT; AGAR GEL ELECTROPHORESIS; ARTICLE; CALIBRATION; ENZYME ASSAY; ENZYME BLOOD LEVEL; ENZYME RELEASE; FEMALE; HUMAN; HYPOGLYCEMIA; INSULIN RELEASE; MALE; NORMAL HUMAN; PEPSIN SECRETION; PRIORITY JOURNAL; PROTEIN DEGRADATION; QUANTITATIVE ANALYSIS; STOMACH JUICE; STOMACH SECRETION; VOLUNTEER;

ADULT; ELECTROPHORESIS, AGAR GEL; FEMALE; GASTRIC JUICE; HUMANS; HYPOGLYCEMIA; HYPOGLYCEMIC AGENTS; INSULIN; MALE; PENTAGASTRIN; PEPSIN A; REFERENCE VALUES; STOMACH;

EID: 34247332255     PISSN: 00365521     EISSN: 15027708     Source Type: Journal    
DOI: 10.1080/00365520601010131     Document Type: Article

References (18)

1. Etherington DJ, Taylor WH. Nomenclature of the pepsins. Nature 1967;216:279-80.
2. Taylor WH. Pepsins of patients with peptic ulcer. Nature 1970;277:76-7.
3. Walker V, Taylor WH. Pepsin 1 secretion in chronic peptic ulceration. Gut 1980;21:766-71.
4. Wright CL, Shaw B, Sanders DJ, Reed JD. Variation in the proportions of individual pepsins secreted by the cat in response to vagal stimulation and hypoglycaemia. Clin Sci Molec Med 1975;48:297-305.
5. Jones AT. Further studies into the biochemistry of the human pepsins. [Doctoral dissertation]. University of Liverpool, UK:1992.
6. Roberts NB, Taylor WH. Comparative pepstatin inhibition studies on individual human pepsins and pepsinogens 1, 3 and 5(gastricsin) and pig pepsin A. J Enz Inhib Med Chem 2003;18:209-17.
7. Walker V, Taylor WH. Pepsin 5 in gastric juice: determination and relationship to the alkali-stable activity. Gut 1979; 20:977-82.
8. Pearson JP, Ward R, Allen A, Roberts NB, Taylor WH. Mucous degradation by pepsin: comparison of mucolytic activity of human pepsin 1 and pepsin 3: implications in peptic ulceration. Gut 1986;27:243-8.
9. Pearson JP, Blackburn A, Allen A, Venables C. Pepsin 5 (gastricsin): atypical pH profile of mucolytic activity. Biochem Soc Trans 1990;18:1255-6.
10. Etherington DJ, Roberts NB, Taylor WH. Studies on the gastric and duodenal ulceration; the collagen degrading activity of purified human pepsins 1 and 3. Clin Sci 1980;58:30-1.
11. Kuipers EJ, Thijs JC, Festen HP. The prevalence of Helicobacter pylori in peptic ulcer disease. Aliment Pharmacol Ther 1995;9 Suppl 2:59-69.
12. Sheers R, Roberts NB. The effect of ranitidine and cimetidine on pentagastrin and insulin stimulated gastric secretion. Scand J Gastroenterol 1981;16 Suppl 69:51-7.
13. Sheers R, Roberts NB. The effects of pirenzepine and ranitidine on pepsin secretion. In: Dotevall G, editor. Gastroenterology. London: Chapman-Hall; 1982. pp 83-7.
14. Ford AC, Delaney BC, Forman D, Moayyedi P. The Cochrane data base of systematic reviews. Issue 2. The Cochrane collection. UK: John Wiley & Sons; 2006.
15. Ryle AP, Foltmann B. Human pepsins 1 and 2: heterogeneity and carbohydrate content. In: Kostka V, editor. Aspartate proteinases and their inhibitors. Berlin: Walter de Gruyter; 1985.
16. Pearson JP, Allen A, Roberts NB, Taylor NB. The carbohydrate component of human pepsin 1. Clin Sci 1987;72 Suppl 16:33.
17. Samloff IM. Pepsinogens 1 and I I: purification from human gastric mucosa and radioimmunoassay in serum. Am J Gastroenterol 1982;82:26-33.
18. Roberts NB. Review article: human pepsins: their multiplicity, function and role in reflux disease. Aliment Pharm Ther 2006;24 Suppl 2:2-9.