Comparative pepstatin inhibition studies on individual human pepsins and pepsinogens 1,3 and 5(gastricsin) and pig pepsin A

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 18, Issue 3, 2003, Pages 209-217

  Roberts, N B ^a   Taylor, W H ^a  

^a ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST   (United Kingdom)

Author keywords

Inhibition; Pepsinogens; Pepsins 1,3,5(gastricsin); Pepstatin

Indexed keywords

ASPARTIC PROTEINASE INHIBITOR; ENZYME PRECURSOR; GASTRICSIN; PENTAGASTRIN; PEPSIN A; PEPSINOGEN I; PEPSINOGEN II; PEPSTATIN; PROTEINASE; SEPHADEX;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG BINDING; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; GEL FILTRATION CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; NONHUMAN; PRIORITY JOURNAL; PROVOCATION TEST; STOMACH PH; STOMACH SECRETION;

ANIMALS; ANTI-ULCER AGENTS; BINDING SITES; CARBENOXOLONE; CHROMATOGRAPHY, GEL; CRYSTALLOGRAPHY, X-RAY; DEXTRANS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; HYDROGEN-ION CONCENTRATION; INDICATORS AND REAGENTS; KINETICS; MODELS, MOLECULAR; PEPSIN A; PEPSTATINS; PROTEIN BINDING; PROTEIN CONFORMATION; SWINE;

SUS SCROFA;

EID: 0038351868     PISSN: 14756366     EISSN: None     Source Type: Journal    
DOI: 10.1080/1475636031000076888     Document Type: Article

References (30)

1. Umezawa, H., Aoyagi, T., Morishima, H., Matsuzaki, M., Hamada, M. and Takeuchi, T. (1970) J. Antibiotics 23, 259-262.
2. Aoyagi, T., Kunimoto, S., Morishimo, H., Takeuchi, T. and Umezawa, H. (1971) J. Antibiotics 24, 687-694.
3. Barrett, A.J. and Dingle, J.T. (1972) Biochem. J. 27, 439-441.
4. Etherington, D.J. and Taylor, W.H. (1969) Biochem. J. 113, 663-668.
5. Taylor, W.H. (1970) Nature 227, 76-77.
6. Doll, R., Hill, J.D., Hutton, C. and Underwood, D.J. (1962) Lancet ii, 793-796.
7. Roberts, N.B. and Taylor, W.H. (1973) Clin. Sci. 44, 6.
8. Walker, V. and Taylor, W.H. (1975) In: Jones, F.A. and Parke, D.V., eds, Fourth Symposium On Carbenoxolone (Butterworths, London), pp. 55-73.
9. Kay, A.W. (1953) Br. Med. J. ii, 77-80.
10. Roberts, N.B. (1975) Ph.D Thesis, University of Liverpool.
11. Etherington, D.J. and Taylor, W.H. (1971) Biochem. Biophys. Acta 236, 92-98.
12. Etherington, D.J. and Taylor, W.H. (1970) Biochem. J. 118, 587-594.
13. Anson, M.L. and Mirsky, A.E. (1933) J. Gen. Physiol. 16, 59-63.
14. Seijffers, M.J., Segal, H.J. and Miller, L.L. (1963) Amer. J. Physiol. 205, 1099-1105.
15. Dixon, M. (1972) Biochem. J. 129, 197-199.
16. Kunimoto, S., Aoyagi, T., Morishima, H., Takeuchi, T. and Umezawa, H. (1972) J. Antibiotics 25, 251-255.
17. Roberts, N.B. and Taylor, W.H. (1972) Biochem. J. 128, 103.
18. Waft, L.A., Roberts, N.B. and Taylor, W.H. (1974) Clin. Sci. Molec. Med. 46, 519.
19. Pearson, J.P. and Roberts, N.B. (2001) Clin. Sci. 100, 411-417.
20. Sali, A. and Blundell, T.L. (1993) J. Molec. Biol. 234, 779-815.
21. Kageyama, T. (2002) Cell Mol. Life Sci. 59, 288-306.
22. Herriott, R.M. (1962) J. Gen. Physiol. 45, 57-76.
23. Inokuchi, T., Kobayashi, K. and Horiuchi, S. (1995) Comp. Biochem. Physiol. (B Biochem. Mol. Biol.) 111, 1-7.
24. Fujinaga, M., Chernaia, M.M., Tarasova, N.I., Mosimann, S.C. and James, M.N. (1995) Protein Sci. 4, 960-972.
25. Gaw, A.J., Williams, L.V., Spraggs, C.F. and Jordan, C.C. (1995) Aliment. Pharmacol. Ther. 9, 167-172.
26. Joffe, S.N., Roberts, N.B. and Taylor, W.H. (1980) Digest. Dis. Sci. 25, 837-841.
27. Svedsen, L.B., Christiansen, P.M. and Bonnevie, O. (1979) Scand. J. Gastro. 14, 929-932.
28. Sheers, R. and Roberts, N.B. (1982) Adv. Gastro. Pirenzepine Symp., 35-41.
29. Tang, J., Sepulveda, P., Marciniszyn, Jr., J., Chen, K.C.S., Huang, W.Y., Tao, N., Liu, D. and Lanier, J.P. (1973) Proc. Nat. Acad. Sci. USA 12(1), 34-37.
30. Lineweaver, H. and Burk, D. (1934) J. Amer. Chem. Soc. 56, 658-663.