Increased inhibitory capacity of an anti-C5a complementary peptide following acetylation of N-terminal alanine

Microbiology and Immunology

Volumn 51, Issue 4, 2007, Pages 439-443

  Okada, Noriko ^a   Asai, Suzuka ^a,b   Hotta, Aya ^a   Miura, Noriko ^c   Ohno, Naohito ^c   Farkas, Imre ^a   Hau, Lewis ^a,d   Okada, Hidechika ^a,b,d  

^a NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

^b Fukushimura Hospital   (Japan)

^c TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^d Institute for Protein Science Co   (Japan)

Author keywords

Acetylation; C5a; Complementary peptide; Inflammation

Indexed keywords

ACETIC ACID DERIVATIVE; ALANINE; ANAPHYLATOXIN; CARBOXYPEPTIDASE; COMPLEMENT COMPONENT C5A; GLUCAN; MANNOPROTEIN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CRRY; PEPTIDE; PEPTIDE ACPEPA; PEPTIDE PEPA; UNCLASSIFIED DRUG;

ACETYLATION; AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ARTICLE; CALCIUM TRANSPORT; CANDIDA ALBICANS; CONTROLLED STUDY; GUINEA PIG; INFLAMMATION; MALE; NEUTROPHIL; NONHUMAN; RAT; SHOCK; SKIN MANIFESTATION;

CANDIDA ALBICANS; CAVIA; MUS; RATTUS;

EID: 34247330573     PISSN: 03855600     EISSN: 13480421     Source Type: Journal    
DOI: 10.1111/j.1348-0421.2007.tb03918.x     Document Type: Article

References (23)

1. Abe, M., Hama, H., Shirakusa, T., Iwasaki, A., Ono, N., Kimura, N., Hugli, T.E., Okada, N., Katsuragi, T., and Okada, H. 2005. Contribution of anaphylatoxins to allergic inflammation in human lungs. Microbiol. Immunol. 49: 981-986.
2. Baranyi, L., Campbell, W., Ohshima, K., Fujimoto, S., Boros, M., and Okada, H. 1995. The antisense homology box: a new motif within proteins that encodes biologically active peptides. Nat. Med. 1: 894-901.
3. Baranyi, L., Campbell, W., and Okada, H. 1996. Antisense homology boxes in C5a receptor and C5a anaphylatoxin. J. Immunol. 157: 4591-4601.
4. Campbell, W., Kleiman, L., Baranyi, L., Li, Z., Khorchid, A., Fujita, E., Okada, N., and Okada, H. 2002. A novel genetic algorithm for designing mimetic peptides that interfere with the function of a target molecule. Microbiol. Immunol. 46: 211-215.
5. Campbell, W., Lazoura, E., Okada, N., and Okada, H. 2002. Inactivation of C3a and C5a octapeptides by carboxypeptidase R and carboxypeptidase N. Microbiol. Immunol. 46: 131-134.
6. Campbell, W., Okada, N., and Okada, H. 2001. Carboxypeptidase R (CPR) is an inactivator of complement derived inflammatory peptides and an inhibitor of fibrinolysis. Immunol. Rev. 180: 162-167.
7. Czermak, B.J., Sarma, V., Pierson, C.L., Warner, R.L., Huber-Lang, M., Bless, N.M., Schmal, H., Friedl, H.P., and Ward, P.A. 1999. Protective effects of C5a blockade in sepsis. Nat. Med. 5: 788-792.
8. Ember, J.A., and Hugli, T.E. 1997. Complement factors and their receptors. Immunopharmacology 38: 3-15.
9. Farkas, I., Baranyi, L., Liposits, Z.S., Yamamoto, T., and Okada, H. 1998. Complement C5a anaphylatoxin fragment causes apoptosis in TGW neuroblastoma cells. Neuroscience 86: 903-911.
10. Fujita, E., Farkas, I., Campbell, W., Baranyi, L., Okada, H., and Okada, N. 2004. Inactivation of C5a anaphylatoxin by a peptide that is complementary to a region of C5a. J. Immunol. 172: 6382-6387.
11. Gerard, C., and Gerard, N.P. 1994. C5a anaphylatoxin and its seven transmembrane-segment receptor. Annu. Rev. Immunol. 12: 775-808.
12. Hosokawa, M., Imai, M., Okada, H., and Okada, N. 2004. Inhibition of HIV-1 infection in cells expressing an artificial complementary peptide. Biochem. Biophys. Res. Commun. 324: 236-240.
13. Kurihara, K., Miura, N.N., Uchiyama, M., Ohno, N., Adachi, Y., Aizawa, M., Tamura, H., Tanaka, S., and Yadomae, T. 2000. Measurement of blood clearance time by Limulus G test of Candida-water soluble polysaccharide fraction, CAWS, in mice. FEMS Immunol. Med. Microbiol. 29: 69-76.
14. Matsuo, S., Ichida, S., Takizawa, H., Okada, N., Baranyi, L., Iguchi, A., Morgan, B.P., and Okada, H. 1994. In vivo effects of monoclonal antibodies that functionally inhibit complement regulatory proteins in rats. J. Exp. Med. 180: 1619-1627.
15. Michael, K. 2001. Targeting complement in therapy. Immunol. Rev. 180: 177-189.
16. Miura, N.N., Adachi, Y., Yadomae, T., Tamura, H., Tanaka, S., and Ohno, N. 2003. Structure and biological activity of β-gulcans from yeast and mycelial forms of Candida albicans. Microbiol. Immunol. 47: 173-182.
17. Mizuno, M., Nishikawa, K., Okada, N., Matsuo, S., Ito, K., and Okada, H. 1999. Inhibition of a membrane complement regulatory protein by a monoclonal antibody induces acute lethal shock in rats primed with lipopolysaccharide. J. Immunol. 162: 5477-5482.
18. Nagi-Miura, N., Shingo, Y., Adachi, Y., Ishida-Okawara, A., Oharaseki, T., Takahashi, K., Naoe, S., Suzuki, K., and Ohno, N. 2004. Induction of coronary arteritis with administration of CAWS (Candida albicans water-soluble fraction) depending on mouse strains. Immunopharmacol. Immunotoxicol. 26: 527-543.
19. Ohno, N. 2003. Chemistry and biology of angiitis inducer, Candida albicans water-soluble mannoprotein-β-glucan complex (CAWS). Microbiol. Immunol. 47: 479-490.
20. Shimomura, Y., Kawamura, T., Komura, H., Campbell, W., Okada, N., and Okada, H. 2003. Modulation of procarboxypeptidase R (proCPR) activation by complementary peptides to thrombomodulin. Microbiol. Immunol. 47: 241-245.
21. Stevens, J.H., O'Hanley, P., Shapiro, J.M., Mihm, F.G., Satoh, P.S., Collins, J.A., and Raffin, T. A. 1986. Effects of anti-C5a antibodies on the adult respiratory distress syndrome in septic primates. J. Clin. Invest. 77: 1812-1816.
22. Takizawa, H., Okada, N., and Okada, H. 1994. Complement inhibitor of rat cell membrane resembling mouse Crry/p65. J. Immunol. 152: 3032-3038.
23. Tani, S., Akatsu, H., Ishikawa, Y., Okada, N., and Okada, H. 2003. Preferential detection of pro-carboxypeptidase R by enzyme-linked immunosorbent assay. Microbiol. Immunol. 47: 295-300.