Frequent high telomerase reverse transcriptase expression in primary oral squamous cell carcinoma

Journal of Oral Pathology and Medicine

Volumn 36, Issue 5, 2007, Pages 267-272

  Freier, Kolja ^a,b   Pungs, Susanne ^a   Flechtenmacher, Christa ^a   Bosch, Franz X ^a   Lichter, Peter ^b   Joos, Stefan ^b   Hofele, Christof ^a  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

Fluorescence in situ hybridization; Human telomerase reverse transcriptase; Immunohistochemistry; Oral squamous cell carcinoma; TERT; Tissue microarray

Indexed keywords

BIOLOGICAL MARKER; TELOMERASE REVERSE TRANSCRIPTASE;

ADOLESCENT; ADULT; AGED; ARTICLE; CANCER PATIENT; CONTROLLED STUDY; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LARYNX CARCINOMA; MAJOR CLINICAL STUDY; MALE; MOUTH CARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; SQUAMOUS CELL CARCINOMA; STATISTICAL SIGNIFICANCE; TISSUE MICROARRAY;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, SQUAMOUS CELL; FEMALE; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LARYNGEAL NEOPLASMS; LOGISTIC MODELS; MALE; MIDDLE AGED; MOUTH NEOPLASMS; NEOPLASM PROTEINS; PHARYNGEAL NEOPLASMS; SURVIVAL ANALYSIS; TELOMERASE;

EID: 34247328669     PISSN: 09042512     EISSN: 16000714     Source Type: Journal    
DOI: 10.1111/j.1600-0714.2007.00531.x     Document Type: Article

References (28)

1. Casiglia J, Woo SB. A comprehensive review of oral cancer. Gen Dent 2001 49: 72 82.
2. Okafuji M, Ita M, Hayatsu Y, Shinozaki F, Oga A, Sasaki K. Identification of genetic aberrations in cell lines from oral squamous cell carcinomas by comparative genomic hybridization. J Oral Pathol Med 1999 28: 241 5.
3. Uchida K, Oga A, Okafuji M et al. Molecular cytogenetic analysis of oral squamous cell carcinomas by comparative genomic hybridization, spectral karyotyping, and fluorescence in situ hybridization. Cancer Genet Cytogenet 2006 167: 109 16.
4. Bentz M, Plesch A, Stilgenbauer S, Dohner H, Lichter P. Minimal sizes of deletions detected by comparative genomic hybridization. Genes Chromosomes Cancer 1998 21: 172 5.
5. Meyerson M, Counter CM, Eaton EN et al. hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. Cell 1997 90: 785 95.
6. Kolquist KA, Ellisen LW, Counter CM et al. Expression of TERT in early premalignant lesions and a subset of cells in normal tissues. Nat Genet 1998 19: 182 6.
7. Shay JW, Zou Y, Hiyama E, Wright WE. Telomerase and cancer. Hum Mol Genet 2001 10: 677 85.
8. Kim HR, Christensen R, Park NH, Sapp P, Kang MK, Park NH. Elevated expression of hTERT is associated with dysplastic cell transformation during human oral carcinogenesis in situ. Clin Cancer Res 2001 7: 3079 86.
9. Downey MG, Going JJ, Stuart RC, Keith WN. Expression of telomerase RNA in oesophageal and oral cancer. J Oral Pathol Med 2001 30: 577 81.
10. Freier K, Joos S, Flechtenmacher C et al. Tissue microarray analysis reveals site-specific prevalence of oncogene amplifications in head and neck squamous cell carcinoma. Cancer Res 2003 63: 1179 82.
11. Freier K, Bosch FX, Flechtenmacher C et al. Distinct site-specific oncoprotein overexpression in head and neck squamous cell carcinoma: a tissue microarray analysis. Anticancer Res 2003 23: 3971 7.
12. Sticht C, Hofele C, Flechtenmacher C et al. Amplification of Cyclin L1 is associated with lymph node metastases in head and neck squamous cell carcinoma (HNSCC). Br J Cancer 2005 92: 770 4.
13. Sparano A, Quesnelle KM, Kumar MS et al. Genome-wide profiling of oral squamous cell carcinoma by array-based comparative genomic hybridization. Laryngoscope 2006 116: 735 41.
14. Volpi A, Bravaccini S, Medri L, Cerasoli S, Gaudio M, Amadori D. Usefulness of immunological detection of the human telomerase reverse transcriptase. Cell Oncol 2005 27: 347 53.
15. Domont J, Pawlik TM, Boige V et al. Catalytic subunit of human telomerase reverse transcriptase is an independent predictor of survival in patients undergoing curative resection of hepatic colorectal metastases: a multicenter analysis. J Clin Oncol 2005 23: 3086 93.
16. Janknecht R. On the road to immortality: hTERT upregulation in cancer cells. FEBS Lett 2004 564: 9 13.
17. Koscielny S, Eggeling F, Dahse R, Fiedler W. The influence of reactivation of the telomerase in tumour tissue on the prognosis of squamous cell carcinomas in the head and neck. J Oral Pathol Med 2004 33: 538 42.
18. Lee BK, Diebel E, Neukam FW, Wiltfang J, Ries J. Diagnostic and prognostic relevance of expression of human telomerase subunits in oral cancer. Int J Oncol 2001 19: 1063 8.
19. McGregor F, Muntoni A, Fleming J et al. Molecular changes associated with oral dysplasia progression and acquisition of immortality: potential for its reversal by 5-azacytidine. Cancer Res 2002 62: 4757 66.
20. Zhang P, Xu Q, Chen WT, Duan LQ, Zhang ZY, Zhou XJ. Synergistic down-regulation of telomerase by all-trans retinoic acid and antisense oligonucleotide in oral squamous cell carcinoma cell line (Tca8113). Oral Oncol 2005 41: 909 15.
21. Takuma Y, Nouso K, Kobayashi Y et al. Telomerase reverse transcriptase gene amplification in hepatocellular carcinoma. J Gastroenterol Hepatol 2004 19: 1300 4.
22. Mosse YP, Greshock J, Margolin A et al. High-resolution detection and mapping of genomic DNA alterations in neuroblastoma. Genes Chromosomes Cancer 2005 43: 390 403.
23. Weber RG, Scheer M, Born IA et al. Recurrent chromosomal imbalances detected in biopsy material from oral premalignant and malignant lesions by combined tissue microdissection, universal DNA amplification, and comparative genomic hybridization. Am J Pathol 1998 153: 295 303.
24. Baldwin C, Garnis C, Zhang L, Rosin MP, Lam WL. Multiple microalterations detected at high frequency in oral cancer. Cancer Res 2005 65: 7561 7.
25. Veldman T, Liu X, Yuan H, Schlegel R. Human papillomavirus E6 and Myc proteins associate in vivo and bind to and cooperatively activate the telomerase reverse transcriptase promoter. Proc Natl Acad Sci U S A 2003 100: 8211 6.
26. Huang Q, Yu GP, McCormick SA et al. Genetic differences detected by comparative genomic hybridization in head and neck squamous cell carcinomas from different tumor sites: construction of oncogenetic trees for tumor progression. Genes Chromosomes Cancer 2002 34: 224 33.
27. Hahn WC, Stewart SA, Brooks MW et al. Inhibition of telomerase limits the growth of human cancer cells. Nat Med 1999 5: 1164 70.
28. Hochreiter AE, Xiao H, Goldblatt EM et al. Telomerase template antagonist GRN163L disrupts telomere maintenance, tumor growth, and metastasis of breast cancer. Clin Cancer Res 2006 12: 3184 92.