Signaling pathways involved in proteinase-activated receptor 1-induced proinflammatory and profibrotic mediator release following lung injury

Annals of the New York Academy of Sciences

Volumn 1096, Issue , 2007, Pages 86-88

  Mercer, Paul F ^a   Deng, Xiaoling ^a   Chambers, Rachel C ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

CCL2; Coagulation; Lung injury; Proteinase activated receptor (PAR); Pulmonary fibrosis

Indexed keywords

BLOOD CLOTTING FACTOR 10A; CHEMOKINE; CYTOKINE; MONOCYTE CHEMOTACTIC PROTEIN 1; PLATELET DERIVED GROWTH FACTOR; PROTEIN KINASE C; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 2; PROTEINASE ACTIVATED RECEPTOR 3; PROTEINASE ACTIVATED RECEPTOR 4; THROMBIN; AUTACOID; PEPTIDE;

ALPHA CHAIN; BLOOD CLOTTING; CELL PROLIFERATION; CELL TYPE; CHEMOTAXIS; CONFERENCE PAPER; CYTOKINE RELEASE; EPITHELIUM CELL; FIBROBLAST; FIBROSIS; LUNG INJURY; ANIMAL; ARTICLE; BIOLOGICAL MODEL; CHEMISTRY; INFLAMMATION; INJURY; LUNG; METABOLISM; MOUSE; PATHOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; CHEMOKINE CCL2; CHEMOKINES; CYTOKINES; FIBROSIS; INFLAMMATION; INFLAMMATION MEDIATORS; LUNG; MICE; MODELS, BIOLOGICAL; PEPTIDES; RECEPTOR, PAR-1; SIGNAL TRANSDUCTION; THROMBIN;

EID: 34247281110     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1397.073     Document Type: Conference Paper

References (6)

1. CHAMBERS, R.C. 2003. Proteinase-activated receptors and the pathophysiology of pulmonary fibrosis. Drug Dev. Res. 60: 29-35.
2. STEINHOFF, M., J. BUDDENKOTTE, V. SHPACOVITCH, et al. 2005. Proteinase-activated receptors: transducers of proteinase-mediated signaling in inflammation and immune response. Endocr. Rev. 26: 1-43.
3. CHAMBERS, R.C., P. LEONI, O.P. BLANC- BRUDE, et al. 2000. Thrombin is a potent inducer of connective tissue growth factor production via proteolytic activation of protease-activated receptor-1. J. Biol. Chem. 275: 35584-35591.
4. HOWELL, D.C., N.R. GOLDSACK, R.P. MARSHALL, et al. 2001. Direct thrombin inhibition reduces lung collagen, accumulation, and connective tissue growth factor mRNA levels in bleomycin-induced pulmonary fibrosis. Am. J. Pathol. 159: 1383-1395.
5. HOWELL, D.C., R.H. JOHNS, J.A. LASKY, et al. 2005. Absence of proteinase-activated receptor-1 signaling affords protection from bleomycin-induced lung inflammation and fibrosis. Am. J. Pathol. 166: 1353-1365.
6. MOORE, B.B., J.E. KOLODSICK, V.J. THANNICKAL, et al. 2005. CCR2-mediated recruitment of fibrocytes to the alveolar space after fibrotic injury. Am. J. Pathol. 166: 675-684.