New germline mutations in the hypervariable minisatellite CEB1 in the parents of children with leukaemia

British Journal of Cancer

Volumn 96, Issue 8, 2007, Pages 1265-1271

  Davies, B G ^a   Hussain, A ^a   Ring, S M ^b   Birch, J M ^a   Eden, T O B ^a   Reeves, M ^a   Dubrova, Y E ^c   Taylor, G M ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

^c UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

Childhood leukaemia; Germline; Minisatellite; Mutation

Indexed keywords

ADOLESCENT; ARTICLE; CANCER PATIENT; CANCER RISK; CHILD; CHILDHOOD LEUKEMIA; CONFIDENCE INTERVAL; CONTROLLED STUDY; GENE FREQUENCY; GENE LOCUS; GENE MUTATION; HUMAN; INFANT; MAJOR CLINICAL STUDY; MICROSATELLITE INSTABILITY; MUTATION RATE; PRIORITY JOURNAL;

ADOLESCENT; ADULT; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; CROSS-SECTIONAL STUDIES; FEMALE; GERM-LINE MUTATION; HUMANS; INFANT; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LEUKEMIA; MALE; MINISATELLITE REPEATS; PARENTS;

EID: 34247277677     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/sj.bjc.6603706     Document Type: Article

References (44)

1. Beral V, Roman E, Bobrow M (1993) Childhood Cancer And Nuclear Installations. London, UK: BMJ Publishing Group
2. Bithell JF, Stewart AM (1975) Pre-natal irradiation and childhood malignancy: a review of British data from the Oxford survey. Br J Cancer 31: 271-287
3. Bouffler SD, Bridges BA, Cooper DN, Dubrova Y, McMillan TJ, Thacker J, Wright EG, Waters R (2006) Assessing radiation-associated mutation risk to the germline: repetitive DNA sequences as mutational targets and biomarkers. Radiat Res 165: 249-268
4. Buard J, Bourdet A, Yardley J, Dubrova Y, Jeffreys AJ (1998) Influences of array size and homogeneity on minisatellite mutation. EMBO J 17: 3495-3502
5. Buard J, Collick A, Brown J, Jeffreys AJ (2000) Somatic versus germline mutation processes at minisatellite CEB1 (D2S90) in humans and transgenic mice. Genomics 65: 95-103
6. Dickinson HO, Parker L (2002) Leukaemia and non-Hodgkin's lymphoma in children of male Sellafield radiation workers. Int J Cancer 99: 437-444
7. Doll R, Evans HJ, Darby SC (1994) Paternal exposure not to blame. Nature 367: 678-680
8. Doll R, Wakeford R (1997) Risk of childhood cancer from fetal irradiation. Br J Radiol 70: 130-139
9. Doyle P, Maconochie N, Roman E, Davies G, Smith PG, Beral V (2000) Fetal death and congenital malformation in babies born to nuclear industry employees: report from the nuclear industry family study. Lancet 356: 1293-1299
10. Dubrova YE, Bersimbaev RI, Djansugurova LB, Tankimanova MK, Mamyrbaeva ZZ, Mustonen R, Lindholm C, Hulten M, Salomaa S (2002b) Nuclear weapons tests and human germline mutation rate. Science 295: 1037
11. Dubrova YE, Grant G, Chumak AA, Stezhka VA, Karakasian AN (2002a) Elevated minisatellite mutation rate in the post-Chernobyl families from Ukraine. Am J Hum Genet 71: 801-809
12. Dubrova YE, Jeffreys AJ, Malashenko AM (1993) Mouse minisatellite mutations induced by ionizing radiation. Nat Genetics 5: 92-94
13. Dubrova YE, Nesterov VN, Krouchinsky NG, Ostapenko VA, Neumann R, Neil DL, Jeffreys AJ (1996) Human minisatellite mutation rate after the Chernobyl accident. Nature 380: 683-686
14. Dubrova YE, Nesterov VN, Krouchinsky NG, Ostapenko VA, Vergnaud G, Giraudeau F, Buard J, Jeffreys AJ (1997) Further evidence for elevated human minisatellite mutation rate in Belarus eight years after the Chernobyl accident. Mut Res 381: 267-278
15. Evans HJ (1990) Ionising radiations from nuclear establishments and childhood leukaemias-an enigma. BioEssays 12: 541-549
16. Gardner MJ, Snee MP, Hall AJ, Powell CA, Downes S, Terrell JD (1990) Results of case-control study of leukaemia and lymphoma among young people near Sellafield nuclear plant in West Cumbria. BMJ 300: 423-429
17. Greaves MF (1997) Aetiology of acute leukaemia. Lancet 349: 344-349
18. Greaves M (1999) Molecular genetics, natural history and the demise of childhood leukaemia. Eur J Cancer 35: 1941-1953
19. Izumi S, Koyama K, Soda M, Suyama A (2003) Cancer incidence in children and young adults did not increase relative to parental exposure to atomic bombs. Br J Cancer 89: 1709-1713
20. Jones RW, Ring S, Tyfield L, Hamvas R, Simmons H, Pembrey M, Golding J, the ALSPAC Study Team (2000) A new human genetics resource: a DNA bank established as part of the Avon Longitudinal Study of Pregnancy and Childhood (ALSPAC). Eur J Human Genetics 8: 653-660
21. Kasai K, Nakamura Y, White R (1990) Amplification of a variable number of tandem repeats (VNTR) locus (pMCT118) by the polymerase chain reaction (PCR) and its application to forensic science. J Forensic Sci 35: 1196-1200
22. Kodaira M, Satoh C, Hiyama K, Toyama K (1995) Lack of effects of atomic bomb radiation on genetic instability of tandem-repetitive elements in human germ cells. Am J Hum Genet 57: 1275-1283
23. Kodaira M, Izumi S, Takahashi N, Nakamura N (2004) No evidence of radiation effect on mutation rates at hypervariable minisatellite loci in the germ cells of atomic bomb survivors. Radiat Res 162: 350-356
24. Little J (1999) Epidemiology of Childhood Cancer. Lyon, France: International Agency for Research on Cancer
25. Nag DK (2003) Trinucleotide repeat expansions: timing is everything. Trends Mol Med 9: 455-457
26. Niwa O (2003) Induced genomic instability in irradiated germ cells and in the offspring; reconciling discrepancies among the human and animal studies. Oncogene 22: 7078-7086
27. Ong KK, Petry CJ, Barratt BJ, Ring S, Cordell HJ, Wingate DL, The Avon Longitudinal Study of Pregnancy and Childhood Study Team Pembrey ME, Todd JA, Dunger DB (2004) Maternal-fetal interactions and birth order influence insulin variable number of tandem repeats allele class associations with head size at birth and childhood weight gain. Diabetes 53: 1128-1133
28. Parker L, Pearce MS, Dickinson HO, Aitkin M, Craft AW (1999) Stillbirths among offspring of male radiation workers at Sellafield nuclear reprocessing plant. Lancet 354: 1407-1414
29. Ring SM, Spanakis E, Beavan T, Barratt B, Jones R, Day I, Pembrey M, Tyfield L, The ALSPAC Study Team (2001) Postal collection of buccal wash samples for DNA: a successful method for expansion of the ALSPAC DNA resource. Eur J Human Genetics 9: 262
30. Ruitberg CM, Reeder DJ, Butler JM (2001) STRBase: a short tandem repeat DNA database for the human identity testing community. Nucleic Acids Res 29: 320-322
31. Stead JDH, Jeffreys AJ (2000) Allele diversity and germline mutation at the insulin minisatellite. Hum Mol Genet 9: 713-723
32. Steinberg KK, Relling MV, Gallagher ML, Greene CN, Rubin CS, French D, Holmes AK, Carroll WL, Koontz DA, Sampson EJ, Satten GA (2006) Genetic studies of a cluster of acute lymphoblastic leukemia cases in Churchill County. Nevada. Environ Health Persp in press (doi:10:1289/ehp.9025)
33. Stewart A, Kneale GW (1968) Changes in the cancer risk associated with obstetric radiography. Lancet 291: 104-107
34. Stewart AM, Kneale GW (1970) Age-distribution of cancers caused by obstetric X-rays and their relevance to cancer latent periods. Lancet 296: 4-8
35. Stewart AM, Webb J, Giles D, Hewitt D (1956) Malignant disease in childhood and diagnostic irradiation in utero. Lancet 268: 447
36. Stiller CA (2004) Epidemiology and genetics of childhood cancer. Oncogene 23: 6429-6444
37. Tamaki K, May CA, Dubrova YE, Jeffreys AJ (1999) Extremely complex repeat shuffling during germline mutation at human minisatellite B6.7. Hum Mol Genet 8: 879-888
38. Taylor GM, Dearden S, Ravetto P, Ayres M, Watson P, Hussain A, Greaves M, Alexander F, Eden OB, UKCCS Investigators (2002) Genetic susceptibility to childhood common acute paediatric lymphoblastic leukaemia is associated with polymorphic peptide-binding pocket profiles in HLA-DPB1*0201. Human Mol Genet 11: 1585-1597
39. UK Childhood Cancer Study Investigators (2000) The United Kingdom Childhood Cancer Study: objectives, materials and methods. Br J Cancer 82: 1073-1102
40. Vergnaud G, Denoeud F (2000) Minisatellites: mutability and genome architecture. Genome Res 10: 899-907
41. Vergnaud G, Mariat D, Apiou F, Aurias A, Lathrop M, Lauthier V (1991) The use of synthetic tandem repeats to isolate new VNTR loci: cloning of a human hypermutable sequence. Genomics 11: 135-144
42. Wakeford R, Little MP (2003) Risk coefficients for childhood cancer after intrauterine irradiation: a review. Int J Radiat Biol 79: 293-309
43. Wakeford R, Tawn EJ, McElvenny DM, Binks K, Scott LE, Parker L (1994) The Seascale childhood leukaemia cases - the mutation rates implied by paternal preconceptional radiation doses. J Radiol Prot 14: 17-24
44. Yauk CL (2004) Advances in the application of germline tandem repeat instability for in situ monitoring. Mut Res 566: 169-182