Oxytocin receptor is differentially expressed in mouse endometrium and embryo during blastocyst implantation

Annals of the New York Academy of Sciences

Volumn 1092, Issue , 2006, Pages 466-479

  Beretsos, Panagiotis ^a,b   Loutradis, Dimitris ^a   Koussoulakos, Stauros ^b   Margaritis, Loukas H ^b   Kiapekou, Erasmia ^a   Mastorakos, George ^c   Papaspirou, Irini ^a   Makris, Nikolaos ^a   Makrigiannakis, Antonis ^d   Antsaklis, Aris ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^b UNIVERSITY OF ATHENS   (Greece)

^c UNIVERSITY OF ATHENS   (Greece)

^d UNIVERSITY OF CRETE   (Greece)

Author keywords

Early development; Embryo; Implantation; Oxytocin; Oxytocin receptor

Indexed keywords

MESSENGER RNA; OXYTOCIN; OXYTOCIN RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; BLASTOCYST; CALCULATION; CONFERENCE PAPER; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; ENDOMETRIUM; FEMALE; FERTILIZATION; FERTILIZATION IN VITRO; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; MOUSE; NIDATION; NONHUMAN; OOCYTE; OVULATION; PREGNANCY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; QUALITATIVE ANALYSIS; REPRODUCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UTERUS; ANIMAL; ARTICLE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM;

MAMMALIA; MUS;

ANIMALS; EMBRYO; EMBRYO IMPLANTATION; ENDOMETRIUM; FEMALE; GENE EXPRESSION REGULATION; MICE; PREGNANCY; RECEPTORS, OXYTOCIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 34247271296     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1365.046     Document Type: Conference Paper

References (45)

1. BEIER, H.M. & K. BEIER-HELLWIG. 1998. Molecular and cellular aspects of endometrial receptivity. Hum. Reprod. Update 4: 448-458.
2. MINAS, V., D. LOUTRADIS & A. MAKRIGIANNAKIS. 2005. Factors controlling blastocyst implantation. Reprod. Biomed. Online. 10: 205-216.
3. MAKRIGIANNAKIS, A. et al. 2006. Hormonal and cytokine regulation of early implantation. Trends Endocrinol. Metab. 17: 178-185.
4. GIMPL, G. & F. FAHRENHOLZ. 2001. The oxytocin receptor system: structure, function, and regulation. Physiol. Rev. 81: 629-683.
5. STEINWALL, M. et al. 2004. Oxytocin mRNA content in the endometrium of non-pregnant women. BJOG 111: 266-270.
6. BAE, S.E. & E.D. WATSON. 2003. A light microscopic and ultrastructural study on the presence and location of oxytocin in the equine endometrium. Theriogenology 60: 909-921.
7. ZEEMAN, G.G., F.S. KHAN-DAWOOD & M.Y. DAWOOD. 1997. Oxytocin and its receptor in pregnancy and parturition: current concepts and clinical implications. Obstet. Gynecol. 89: 873-883.
8. PAQUIN, J. et al. 2002. Oxytocin induces differentiation of P19 embryonic stem cells to cardiomyocytes. Proc. Natl. Acad. Sci. USA 99: 9550-9555.
9. CASSONI, P. et al. 2004. Evidence of oxytocin/oxytocin receptor interplay in human prostate gland and carcinomas. Int. J. Oncol. 25: 899-904.
10. REVERSI, A. et al. 2005. The oxytocin receptor antagonist atosiban inhibits cell growth via a "biased agonist" mechanism. J. Biol. Chem. 280: 16311-16318.
11. AMICO, J.A., P.N. RAUK & H.M. CAI. 2002. Estradiol and progesterone regulate oxytocin receptor binding and expression in human breast cancer cell lines. Endocrine 18: 79-84.
12. KOMBE, A., J. SIROIS & A.K. GOFF. 2003. Prolonged progesterone treatment of endometrial epithelial cells modifies the effect of estradiol on their sensitivity to oxytocin. Steroids 68: 651-658.
13. MURATA, T. et al. 2000. Oxytocin receptor gene expression in rat uterus: regulation by ovarian steroids. J. Endocrinol. 166: 45-52.
14. LEUNG, S.T. et al. 2001. The effects of lipopolysaccharide and interleukins-1alpha, -2 and -6 on oxytocin receptor expression and prostaglandin production in bovine endometrium. J. Endocrinol. 168: 497-508.
15. RAUK, P.N. et al. 2001. Interleukin-6 up-regulates the oxytocin receptor in cultured uterine smooth muscle cells. Am. J. Reprod. Immunol. 45: 148-153.
16. ROBINSON, R.S. et al. 2001. Expression of oxytocin, oestrogen and progesterone receptors in uterine biopsy samples throughout the oestrous cycle and early pregnancy in cows. Reproduction 122: 965-979.
17. EINSPANIER, A., A. BIELEFELD & J.H. KOPP. 1998. Expression of the oxytocin receptor in relation to steroid receptors in the uterus of a primate model, the marmoset monkey. Hum. Reprod. Update 4: 634-646.
18. KIMURA, T. 1998. Regulation of the human oxytocin receptor in the uterus: a molecular approach. Hum. Reprod. Update 4: 615-624.
19. LOUTRADIS, D. et al. 1994. The effect of compounds altering the cAMP level on reversing the 2-cell block induced by hypoxanthine in mouse embryos in vitro. Eur. J. Obstet. Gynecol. Reprod. Biol. 57: 195-199.
20. SAMBROOK, J., T. MANIATIS & E.F. FRITSCH. 1989. Molecular Cloning a Laboratory Manual. Cold Spring Harbor Laboratory Press. New York, NY.
21. DALE, H.H. 1909. The action of extracts of the pituitary body. Biochem. J. 4: 427-447.
22. BERETSOS, P. et al. 2006. The role of oxytocin in early embryo development and implantation of mouse embryos. Hum. Reprod. Abstracts of the 22nd Annual Meeting of the ESHRE. 21(Suppl. 1): i29.
23. HELMER, H. et al. 1998. Oxytocin and vasopressin 1a receptor gene expression in the cycling or pregnant human uterus. Am. J. Obstet. Gynecol. 179: 1572-1578.
24. QUINONES-JENAB,V. et al. 1997. Effects of estrogen on oxytocin receptor messenger ribonucleic acid expression in the uterus, pituitary, and forebrain of the female rat. Neuroendocrinology 65: 9-17.
25. LARCHER, A. et al. 1995. Oxytocin receptor gene expression in the rat uterus during pregnancy and the estrous cycle and in response to gonadal steroid treatment. Endocrinology 136: 5350-5356.
26. PATISAUL, H.B. et al. 2003. Oxytocin, but not oxytocin receptor, is regulated by oestrogen receptor beta in the female mouse hypothalamus. J. Neuroendocrinol. 15: 787-793.
27. SIEBEL, A.L., H.M. GEHRING & L.J. PARRY. 2004. Steroid-independent regulation of uterine oxytocin receptors. J. Neuroendocrinol. 16: 398-402.
28. GRAZZINI, E. et al. 1998. Inhibition of oxytocin receptor function by direct binding of progesterone. Nature 392: 509-512.
29. ZHANG, J., P.G. WESTON & J.E. HIXON. 1992. Role of progesterone and oestradiol in the regulation of uterine oxytocin receptors in ewes. J. Reprod. Fertil. 94: 395-404.
30. MUELLER, A. et al. 2006. Role of estrogen and progesterone in the regulation of uterine peristalsis: results from perfused non-pregnant swine uteri. Hum. Reprod. 21: 1863-1868.
31. FANCHIN, R. et al. 2001. Uterine contractility decreases at the time of blastocyst transfers. Hum. Reprod. 16: 1115-1119.
32. BULLETTI, C. & D. DE ZIEGLER. 2006. Uterine contractility and embryo implantation. Curr. Opin. Obstet. Gynecol. 18: 473-484.
33. LOUTRADIS, D. et al. 2006. Estradiol and progesterone supplementation during luteal phase improved the receptivity of the endometrium in a patient with a history of diethylstilboestrol exposure in-utero. Hormones (Athens) 5: 147-150.
34. PROCTOR, A. et al. 2006. Effect of progesterone supplementation in early pregnancy on the pregnancy outcome after in vitro fertilization. Fertil. Steril. 85: 1550-1552.
35. DE, M.,T.R. SANFORD & G.W. WOOD. 1993. Expression of interleukin 1, interleukin 6 and tumour necrosis factor alpha in mouse uterus during the peri-implantation period of pregnancy. J. Reprod. Fertil. 97: 83-89.
36. KUBOTA, Y. et al. 1996. Structure and expression of the mouse oxytocin receptor gene. Mol. Cell Endocrinol. 124: 25-32.
37. STOJKOVIC, M. et al. 1999. Secretion of interferon-tau by bovine embryos in long-term culture: comparison of in vivo derived, in vitro produced, nuclear transfer and demi-embryos. Anim. Reprod. Sci. 55: 151-162.
38. LO, W.C. & P.M. SUMMERS. 2002. In vitro culture and interferon-tau secretion by ovine blastocysts. Anim. Reprod. Sci. 70: 191-202.
39. HORN, S. et al. 1998. Bovine endometrial epithelial cells as a model system to study oxytocin receptor regulation. Hum. Reprod. Update 4: 605-614.
40. SPENCER, T.E. & F.W. BAZER. 1996. Ovine interferon tau suppresses transcription of the estrogen receptor and oxytocin receptor genes in the ovine endometrium. Endocrinology 137: 1144-1147.
41. FLINT, A.P. 1995. Interferon, the oxytocin receptor and the maternal recognition of pregnancy in ruminants and non-ruminants: a comparative approach. Reprod. Fertil. Dev. 7: 313-318.
42. YOSHIMURA, R. et al. 1996. Differential expression of oxytocin receptor mRNA in the developing rat brain. Neurosci. Res. 24: 291-304.
43. COPLAND, J.A. et al. 2002. Oxytocin receptor regulation and action in a human granulosa-lutein cell line. Biol. Reprod. 66: 1230-1236.
44. JO, M. & J.E. FORTUNE. 2003. Changes in oxytocin receptor in bovine preovulatory follicles between the gonadotropin surge and ovulation. Mol. Cell. Endocrinol. 200: 31-43.
45. CASSONI, P. et al. 2001. Activation of functional oxytocin receptors stimulates cell proliferation in human trophoblast and choriocarcinoma cell lines. Endocrinology 142: 1130-1136.