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14
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0026509053
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The bromination of 2-hexanone gives besides 1-bromohexan-2-one also the 3-bromoregioisomer: Thomas, A. P.; Allott, C. P.; Gibson, K. H.; Major, J. S.; Masek, B. B.; Oldham, A. A.; Ratcliffe, A. H.; Roberts, D. A.; Russell, S. T.; Thomason, D. A. J. Med. Chem. 1992, 35, 877-885.
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(a) The bromination of 2-hexanone gives besides 1-bromohexan-2-one also the 3-bromoregioisomer: Thomas, A. P.; Allott, C. P.; Gibson, K. H.; Major, J. S.; Masek, B. B.; Oldham, A. A.; Ratcliffe, A. H.; Roberts, D. A.; Russell, S. T.; Thomason, D. A. J. Med. Chem. 1992, 35, 877-885.
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15
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0030054110
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For the synthesis of 1-amino-2-hexan-2-one by Gabriel synthesis, see: Brown, P.; Davies, D. T.; O'Hanlon, P. J.; Wilson, J. M. J. Med. Chem. 1996, 39, 446-457.
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(b) For the synthesis of 1-amino-2-hexan-2-one by Gabriel synthesis, see: Brown, P.; Davies, D. T.; O'Hanlon, P. J.; Wilson, J. M. J. Med. Chem. 1996, 39, 446-457.
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16
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34247187100
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The reaction of epoxide 19 with ammonia resulted in a mixture of mono-, bis-, and tris(2-hydroxyhex-1-yl)amines; benzylamine and 19 led to a 1:1 mixture of the mono- and bis(2-hydroxyhex-1-yl)benzylamines.
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The reaction of epoxide 19 with ammonia resulted in a mixture of mono-, bis-, and tris(2-hydroxyhex-1-yl)amines; benzylamine and 19 led to a 1:1 mixture of the mono- and bis(2-hydroxyhex-1-yl)benzylamines.
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18
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34247249540
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The condensation of 21 and 23 in the presence of diisopropyl carbodimide instead of DCC gave a lower yield of the amide 25.
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The condensation of 21 and 23 in the presence of diisopropyl carbodimide instead of DCC gave a lower yield of the amide 25.
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19
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34247262278
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The direct condensation between the ester 22 and alcohol 21 gave a moderate yield (51%) of 25. 2-Hydroxypyridine catalyses this reaction; in a side reaction also 5% of the 1-amino-hex-2-enyl-estar was formed.
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The direct condensation between the ester 22 and alcohol 21 gave a moderate yield (51%) of 25. 2-Hydroxypyridine catalyses this reaction; in a side reaction also 5% of the 1-amino-hex-2-enyl-estar was formed.
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21
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0034641294
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Okhuma, N.; Ishii, D.; Takeno, H.; Noyori, R. J. Am. Chem. Soc. 2000, 122, 6510-6511.
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Okhuma, N.1
Ishii, D.2
Takeno, H.3
Noyori, R.4
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