New Nonpeptide Angiotensin II Receptor Antagonists. 1. Synthesis, Biological Properties and Structure-Activity Relationships of 2-Alkyl Benzimidazole Derivatives

Journal of Medicinal Chemistry

Volumn 35, Issue 5, 1992, Pages 877-885

  Thomas, Andrew P ^a   Allott, Christopher P ^a   Gibson, Keith H ^a   Major, John S ^a   Oldham, Alec A ^a   Ratcliffe, Arnold H ^a   Roberts, David A ^a   Russell, Simon T ^a   Thomason, Douglas A ^a   Masek, Brian B ^b  

^a AKZO NOBEL CENTRAL RESEARCH   (Netherlands)

^b ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN; ANGIOTENSIN II ANTAGONIST; BENZIMIDAZOLE DERIVATIVE;

ANIMAL MODEL; ARTICLE; BINDING AFFINITY; BLOOD PRESSURE REGULATION; CHEMICAL STRUCTURE; DRUG POTENCY; HYPERTENSION; INTRAVENOUS DRUG ADMINISTRATION; LIPOPHILICITY; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; STRUCTURE ACTIVITY RELATION;

ANGIOTENSIN II; ANIMAL; BENZIMIDAZOLES; BINDING, COMPETITIVE; BLOOD PRESSURE; GUINEA PIGS; HYPERTENSION; MALE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; RABBITS; RATS; RATS, INBRED STRAINS; RECEPTORS, ANGIOTENSIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0026509053     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00083a011     Document Type: Article

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