Simultaneous enantiomer determination of 20 (R)- and 20 (S)-ginsenoside-Rg2 in rat plasma after intravenous administration using HPLC method

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 850, Issue 1-2, 2007, Pages 1-6

  Gui, Fang Jin ^a   Yang, Xiu Wei ^a   Li, Long Yun ^b   Tian, Jian Ming ^b  

^a PEKING UNIVERSITY   (China)

^b CHANGCHUN UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

20 (R) Ginsenoside Rg2; 20 (R,S) Ginsenoside Rg2; 20 (S) Ginsenoside Rg2; Enantiomeric separation; Pharmacokinetics

Indexed keywords

ABSORPTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; PHARMACOKINETICS; PLASMA APPLICATIONS; SEPARATION;

ENANTIOMERIC SEPARATION; GINSENOSIDE; INTRAVENOUS ADMINISTRATION; REVERSED PHASE COLUMN;

ENANTIOMERS;

GINSENOSIDE RG 2;

ANIMAL EXPERIMENT; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG METABOLISM; DRUG STRUCTURE; ENANTIOMER; FEMALE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; REVIEW; SOLID PHASE EXTRACTION; ULTRAVIOLET RADIATION;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GINSENOSIDES; INJECTIONS, INTRAVENOUS; RATS; REPRODUCIBILITY OF RESULTS; STEREOISOMERISM;

RATTUS;

EID: 34247231045     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2006.11.008     Document Type: Review

References (18)

1. Attele A.S., Wu J.A., and Yuan C.S. Pharmacol. Biochem. Pharmacol. 58 (1999) 1685
2. Lee B.H., Jeong S.M., Lee J.H., Kim D.H., Kim J.H., Kim J.I., Shin H.C., Lee S.M., and Nah S.Y. Mol. Cells 17 (2004) 51
3. Kiefer D., and Pantuso T. Am. Fam. Physician 68 (2003) 1539
4. Yang X.W., Hao M.R., and Hattori M. Metabolite Analysis for Chemical Constituents of Traditional Chinese Medicines (2004), China Medical-Pharmaceutical Science and Technology Publishing House, Beijing p. 346
5. Sun W.J., Liu J., Qu S.C., Jin Y., Zhang Z.W., and Li L.Y. Chin. J. Mod. Appl. Pharm. 21 (2004) 447
6. Lu W.W., Liu J., Zhao L.J., Tian J.M., Li L.Y., and Yang S.J. J. Jilin Univ. (Med. Ed.) 30 (2004) 534
7. Cui X.M., Cui Y.N., Li Y.R., and Cui L. J. Chin. Electron Microsc. Soc. 23 (2004) 309
8. Tian J.M., Zheng S.Q., Guo W.F., Ye J.M., and Li L.Y. Chin. Pharmacol. Bull. 20 (2004) 480
9. Tian J.M., Li H., Ye J.M., Guo W.F., Li L.Y., and Wang L.P. China J. Chin. Mater. Med. 28 (2003) 1191
10. Suzuki A., Takagaki S., Suzuki H., and Noda K. J. Chromatogr. 617 (1993) 279
11. Doroudian A., Yeleswaram K., Rurak D.W., Abbott F.S., and Axelson J.E. J. Chromatogr. 619 (1993) 79
12. Becker-Scharfenkamp U., and Blaschke G. J. Chromatogr. 621 (1993) 199
13. de Vries J.X., and Schmitz-Kummer E. J. Chromatogr. 644 (1993) 315
14. Wallen L., Ericsson O., Wikstrom I., and Hellgren U. J. Chromatogr. B 655 (1994) 153
15. Demetriou D., Rustemeier K., Voncken P., and Schepers G. Chirality 5 (1993) 300
16. Yang X.W. Chin. J. Magn. Reson. 17 (2000) 9
17. Wainer I.W. Drug Stereochemistry: Analytical Methods and Pharmacology. 2nd Ed. (1993), Marcel Dekker, New York p. 139
18. Fuzzati N. J. Chromatogr. B 812 (2004) 119