Development of a liquid chromatography/tandem mass spectrometry assay for the determination of bestatin in rat plasma and its application to a pharmacokinetic study

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 850, Issue 1-2, 2007, Pages 101-108

  Wang, Chen ^a,b   Fan, Guorong ^a,b   Lin, Mei ^c   Chen, Yi ^a,b   Zhao, Weiquan ^a,b   Wu, Yutian ^a,b  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b SHANGHAI KEY LABORATORY FOR PHARMACEUTICAL METABOLITE RESEARCH   (China)

^c SHANGHAI INSTITUTE FOR FOOD AND DRUG CONTROL   (China)

Author keywords

Bestatin; LC MS MS; Pharmacokinetics

Indexed keywords

ENZYME INHIBITION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MOLECULAR WEIGHT; PHARMACOKINETICS; PLASMA APPLICATIONS;

AMINOPEPTIDASE; BESTATIN; CULTURE FILTRATES; STREPTOMYCES OLIVORETICULI;

BIOASSAY;

BESTATIN; FORMIC ACID; GRANISETRON; METHANOL; WATER;

ACCURACY; ANIMAL EXPERIMENT; ARTICLE; BLOOD FLOW VELOCITY; BLOOD SAMPLING; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG ISOLATION; DRUG METABOLISM; DRUG STABILITY; DRUG STRUCTURE; FEMALE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SENSITIVITY ANALYSIS; SOLID PHASE EXTRACTION; STANDARDIZATION; TANDEM MASS SPECTROMETRY;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEMALE; LEUCINE; MALE; PROTEASE INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

RATTUS; STREPTOMYCES OLIVORETICULI;

EID: 34247213426     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2006.11.015     Document Type: Article

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