Deregulated expression of CD40 ligand in HTLV-I infection: Distinct mechanisms of downregulation in HTLV-I-transformed cell lines and ATL patients

Virology

Volumn 362, Issue 1, 2007, Pages 99-108

  Harhaj, Nicole S ^a   Janic, Branislava ^a   Ramos, Juan C ^a   Harrington Jr , William J ^a   Harhaj, Edward W ^a  

^a UNIVERSITY OF MIAMI   (United States)

Author keywords

ATL; CD40L; Gene expression; HAM TSP; HTLV I; Methylation; NF B; NFAT; Tax

Indexed keywords

CD40 LIGAND; CYCLOSPORIN A; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR TAX; UNCLASSIFIED DRUG;

ADAPTIVE IMMUNITY; ARTICLE; CELL LINE; CELL MATURATION; CELL TRANSFORMATION; CONTROLLED STUDY; DENDRITIC CELL; DOWN REGULATION; EPIGENETICS; EX VIVO STUDY; GENE EXPRESSION; HTLV 1 ASSOCIATED MYELOPATHY; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS 1; HUMAN T CELL LEUKEMIA VIRUS INFECTION; METHYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SPASTIC PARAPLEGIA; SPINAL CORD DISEASE; T CELL LEUKEMIA; T LYMPHOCYTE; TROPICAL SPASTIC PARAPARESIS; UPREGULATION;

ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; CD40 LIGAND; CELL LINE, TRANSFORMED; CYCLOSPORINE; CYTOKINES; DNA METHYLATION; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GENE PRODUCTS, TAX; HUMAN T-LYMPHOTROPIC VIRUS 1; HUMANS; JURKAT CELLS; LEUKEMIA-LYMPHOMA, T-CELL, ACUTE, HTLV-I-ASSOCIATED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; UP-REGULATION;

HUMAN T-LYMPHOTROPIC VIRUS 1;

EID: 34247211117     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2006.12.020     Document Type: Article

References (46)

1. Aruffo A., Farrington M., Hollenbaugh D., Li X., Milatovich A., Nonoyama S., Bajorath J., Grosmaire L.S., Stenkamp R., Neubauer M., et al. The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome. Cell 72 2 (1993) 291-300
2. Baylin S.B., and Ohm J.E. Epigenetic gene silencing in cancer-A mechanism for early oncogenic pathway addiction?. Nat. Rev., Cancer 6 2 (2006) 107-116
3. Bhushan A., and Covey L.R. CD40:CD40L interactions in X-linked and non-X-linked hyper-IgM syndromes. Immunol. Res. 24 3 (2001) 311-324
4. Bigby M., Wang P., Fierro J.F., and Sy M.S. Phorbol myristate acetate-induced down-modulation of CD4 is dependent on calmodulin and intracellular calcium. J. Immunol. 144 8 (1990) 3111-3116
5. Bowen F., Haluskey J., and Quill H. Altered CD40 ligand induction in tolerant T lymphocytes. Eur. J. Immunol. 25 10 (1995) 2830-2834
6. Chougnet C. Role of CD40 ligand dysregulation in HIV-associated dysfunction of antigen-presenting cells. J. Leukocyte Biol. 74 5 (2003) 702-709
7. Clarke S.R. The critical role of CD40/CD40L in the CD4-dependent generation of CD8+ T cell immunity. J. Leukocyte Biol. 67 5 (2000) 607-614
8. Cron R.Q. CD154 transcriptional regulation in primary human CD4 T cells. Immunol. Res. 27 2-3 (2003) 185-202
9. Cron R.Q., Bandyopadhyay R., Genin A., Brunner M., Kersh G.J., Yin J., Finkel T.H., and Crow M.K. Early growth response-1 is required for CD154 transcription. J. Immunol. 176 2 (2006) 811-818
10. Ford G.S., Barnhart B., Shone S., and Covey L.R. Regulation of CD154 (CD40 ligand) mRNA stability during T cell activation. J. Immunol. 162 7 (1999) 4037-4044
11. Foy T.M., Aruffo A., Bajorath J., Buhlmann J.E., and Noelle R.J. Immune regulation by CD40 and its ligand GP39. Annu. Rev. Immunol. 14 (1996) 591-617
12. Fujii M., Niki T., Mori T., Matsuda T., Matsui M., Nomura N., and Seiki M. HTLV-1 Tax induces expression of various immediate early serum responsive genes. Oncogene 6 6 (1991) 1023-1029
13. Fuleihan R., Ramesh N., Horner A., Ahern D., Belshaw P.J., Alberg D.G., Stamenkovic I., Harmon W., and Geha R.S. Cyclosporin A inhibits CD40 ligand expression in T lymphocytes. J. Clin. Invest. 93 3 (1994) 1315-1320
14. Good L., Maggirwar S.B., Harhaj E.W., and Sun S.C. Constitutive dephosphorylation and activation of a member of the nuclear factor of activated T cells, NF-AT1, in Tax-expressing and type I human T-cell leukemia virus-infected human T cells. J. Biol. Chem. 272 3 (1997) 1425-1428
15. Hall W.W., and Fujii M. Deregulation of cell-signaling pathways in HTLV-1 infection. Oncogene 24 39 (2005) 5965-5975
16. Harhaj E.W., and Harhaj N.S. Mechanisms of persistent NF-kappaB activation by HTLV-I tax. IUBMB Life 57 2 (2005) 83-91
17. Harhaj E.W., and Sun S.C. IKKgamma serves as a docking subunit of the IkappaB kinase (IKK) and mediates interaction of IKK with the human T-cell leukemia virus Tax protein. J. Biol. Chem. 274 33 (1999) 22911-22914
18. Harhaj E.W., Good L., Xiao G., and Sun S.C. Gene expression profiles in HTLV-I-immortalized T cells: deregulated expression of genes involved in apoptosis regulation. Oncogene 18 6 (1999) 1341-1349
19. Harhaj E.W., Harhaj N.S., Grant C., Mostoller K., Alefantis T., Sun S.C., and Wigdahl B. Human T cell leukemia virus type I Tax activates CD40 gene expression via the NF-kappa B pathway. Virology 333 1 (2005) 145-158
20. Hironaka N., Mochida K., Mori N., Maeda M., Yamamoto N., and Yamaoka S. Tax-independent constitutive IkappaB kinase activation in adult T-cell leukemia cells. Neoplasia 6 3 (2004) 266-278
21. Jeang K.T., Giam C.Z., Majone F., and Aboud M. Life, death, and tax: role of HTLV-I oncoprotein in genetic instability and cellular transformation. J. Biol. Chem. 279 31 (2004) 31991-31994
22. Jeong S.J., Pise-Masison C.A., Radonovich M.F., Park H.U., and Brady J.N. A novel NF-kappaB pathway involving IKKbeta and p65/RelA Ser-536 phosphorylation results in p53 inhibition in the absence of NF-kappaB transcriptional activity. J. Biol. Chem. 280 11 (2005) 10326-10332
23. Koshy M., Berger D., and Crow M.K. Increased expression of CD40 ligand on systemic lupus erythematosus lymphocytes. J. Clin. Invest. 98 3 (1996) 826-837
24. Kozako T., Arima N., Toji S., Masamoto I., Akimoto M., Hamada H., Che X.F., Fujiwara H., Matsushita K., Tokunaga M., Haraguchi K., Uozumi K., Suzuki S., Takezaki T., and Sonoda S. Reduced frequency, diversity, and function of human T cell leukemia virus type 1-specific CD8+ T cell in adult T cell leukemia patients. J. Immunol. 177 8 (2006) 5718-5726
25. Kubota R., Kawanishi T., Matsubara H., Manns A., and Jacobson S. HTLV-I specific IFN-gamma+ CD8+ lymphocytes correlate with the proviral load in peripheral blood of infected individuals. J. Neuroimmunol. 102 2 (2000) 208-215
26. Lee B.O., Haynes L., Eaton S.M., Swain S.L., and Randall T.D. The biological outcome of CD40 signaling is dependent on the duration of CD40 ligand expression: reciprocal regulation by interleukin (IL)-4 and IL-12. J. Exp. Med. 196 5 (2002) 693-704
27. Liu Z., Colpaert S., D'Haens G.R., Kasran A., de Boer M., Rutgeerts P., Geboes K., and Ceuppens J.L. Hyperexpression of CD40 ligand (CD154) in inflammatory bowel disease and its contribution to pathogenic cytokine production. J. Immunol. 163 7 (1999) 4049-4057
28. Lobo F.M., Xu S., Lee C., and Fuleihan R.L. Transcriptional activity of the distal CD40 ligand promoter. Biochem. Biophys. Res. Commun. 279 1 (2000) 245-250
29. MacDonald K.P., Nishioka Y., Lipsky P.E., and Thomas R. Functional CD40 ligand is expressed by T cells in rheumatoid arthritis. J. Clin. Invest. 100 9 (1997) 2404-2414
30. Makino M., Utsunomiya A., Maeda Y., Shimokubo S., Izumo S., and Baba M. Association of CD40 ligand expression on HTLV-I-infected T cells and maturation of dendritic cells. Scand. J. Immunol. 54 (2001) 574-581
31. Naviaux R.K., Costanzi E., Haas M., and Verma I.M. The pCL vector system: rapid production of helper-free, high-titer, recombinant retroviruses. J. Virol. 70 8 (1996) 5701-5705
32. Ng P.W., Iha H., Iwanaga Y., Bittner M., Chen Y., Jiang Y., Gooden G., Trent J.M., Meltzer P., Jeang K.T., and Zeichner S.L. Genome-wide expression changes induced by HTLV-1 Tax: evidence for MLK-3 mixed lineage kinase involvement in Tax-mediated NF-kappaB activation. Oncogene 20 33 (2001) 4484-4496
33. Rivera-Walsh I., Waterfield M., Xiao G., Fong A., and Sun S.C. NF-kappaB signaling pathway governs TRAIL gene expression and human T-cell leukemia virus-I Tax-induced T-cell death. J. Biol. Chem. 276 44 (2001) 40385-40388
34. Schubert L.A., King G., Cron R.Q., Lewis D.B., Aruffo A., and Hollenbaugh D. The human gp39 promoter. Two distinct nuclear factors of activated T cell protein-binding elements contribute independently to transcriptional activation. J. Biol. Chem. 270 50 (1995) 29624-29627
35. Schubert L.A., Cron R.Q., Cleary A.M., Brunner M., Song A., Lu L.S., Jullien P., Krensky A.M., and Lewis D.B. A T cell-specific enhancer of the human CD40 ligand gene. J. Biol. Chem. 277 9 (2002) 7386-7395
36. Shimoyama M. Diagnostic criteria and classification of clinical subtypes of adult T-cell leukaemia-lymphoma. A report from the Lymphoma Study Group (1984-87). Br. J. Haematol. 79 3 (1991) 428-437
37. Siddiqa A., Sims-Mourtada J.C., Guzman-Rojas L., Rangel R., Guret C., Madrid-Marina V., Sun Y., and Martinez-Valdez H. Regulation of CD40 and CD40 ligand by the AT-hook transcription factor AKNA. Nature 410 6826 (2001) 383-387
38. Srahna M., Remacle J.E., Annamalai K., Pype S., Huylebroeck D., Boogaerts M.A., and Vandenberghe P. NF-kappaB is involved in the regulation of CD154 (CD40 ligand) expression in primary human T cells. Clin. Exp. Immunol. 125 2 (2001) 229-236
39. Sun S.C., and Yamaoka S. Activation of NF-kappaB by HTLV-I and implications for cell transformation. Oncogene 24 39 (2005) 5952-5964
40. Taguchi H., and Miyoshi I. Immune suppression in HTLV-I carriers: a predictive sign of adult T-cell leukemia. Acta Med. Okayama 43 6 (1989) 317-321
41. Takeda S., Maeda M., Morikawa S., Taniguchi Y., Yasunaga J., Nosaka K., Tanaka Y., and Matsuoka M. Genetic and epigenetic inactivation of tax gene in adult T-cell leukemia cells. Int. J. Cancer 109 4 (2004) 559-567
42. Taylor-Fishwick D.A., and Siegel J.N. Raf-1 provides a dominant but not exclusive signal for the induction of CD69 expression on T cells. Eur. J. Immunol. 25 12 (1995) 3215-3221
43. Tsytsykova A.V., Tsitsikov E.N., and Geha R.S. The CD40L promoter contains nuclear factor of activated T cells-binding motifs which require AP-1 binding for activation of transcription. J. Biol. Chem. 271 7 (1996) 3763-3770
44. van Kooten C., and Banchereau J. CD40-CD40 ligand. J. Leukocyte Biol. 67 1 (2000) 2-17
45. Yasunaga J., Taniguchi Y., Nosaka K., Yoshida M., Satou Y., Sakai T., Mitsuya H., and Matsuoka M. Identification of aberrantly methylated genes in association with adult T-cell leukemia. Cancer Res. 64 17 (2004) 6002-6009
46. Zhang R., Fichtenbaum C.J., Hildeman D.A., Lifson J.D., and Chougnet C. CD40 ligand dysregulation in HIV infection: HIV glycoprotein 120 inhibits signaling cascades upstream of CD40 ligand transcription. J. Immunol. 172 4 (2004) 2678-2686