Functional studies of intimin in vivo and ex vivo: Implications for host specificity and tissue tropism

Microbiology

Volumn 153, Issue 4, 2007, Pages 959-967

  Mundy, Rosanna ^a   Schüller, Stephanie ^b   Girard, Francis ^a,c   Fairbrother, John M ^c   Phillips, Alan D ^b   Frankel, Gad ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^c UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

INTIMIN; INTIMIN ALPHA; INTIMIN BETA; INTIMIN GAMMA; UNCLASSIFIED DRUG;

ADOLESCENT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL GROWTH; BACTERIUM ADHERENCE; CHILD; CITROBACTER RODENTIUM; CLINICAL ARTICLE; CONTROLLED STUDY; ENTEROHEMORRHAGIC ESCHERICHIA COLI; ENTEROPATHOGENIC ESCHERICHIA COLI; EX VIVO STUDY; HOST PATHOGEN INTERACTION; HOST RANGE; HUMAN; HUMAN TISSUE; IN VIVO STUDY; INTESTINE INFECTION; LARGE INTESTINE; MALE; MOUSE; NONHUMAN; ORGAN CULTURE; PRIORITY JOURNAL; PROTEIN FUNCTION; SMALL INTESTINE; SWINE;

ADHESINS, BACTERIAL; ANIMALS; BACTERIAL PROTEINS; CITROBACTER RODENTIUM; ENTEROBACTERIACEAE INFECTIONS; ESCHERICHIA COLI INFECTIONS; ESCHERICHIA COLI O157; ESCHERICHIA COLI PROTEINS; HUMANS; INTESTINAL MUCOSA; INTESTINE, SMALL; MICE; MICE, INBRED C3H; ORGAN CULTURE TECHNIQUES; SWINE; VIRULENCE;

ESCHERICHIA COLI; SUIDAE;

EID: 34247188146     PISSN: 13500872     EISSN: None     Source Type: Journal    
DOI: 10.1099/mic.0.2006/003467-0     Document Type: Article

References (30)

1. Adu-Bobie, J., Frankel, G., Bain, C., Goncaleves, A. G., Trabulsi, L. R., Douce, G., Knutton, S. & Dougan, G. (1998). Detection of intimin α, β, γ, and δ, four intimin derivatives expressed by attaching and effacing microbial pathogens. J Clin Microbiol 36, 662-668.
2. Brooks, J. T., Sowers, E. G., Wells, J. G., Greene, K D., Griffin, P. M., Hoekstra, R. M. & Strockbine, N. A. (2005). Non-O157 shiga toxin-producing Escherichia coli infections in the United States, 1983-2002. J Infect Dis 192, 1422-1429.
3. Chen, H. D. & Frankel, G. (2005). Enteropathogenic Escherichia coh: unravelling pathogenesis. FEMS Microbiol Rev 29, 83-98.
4. Deng, W., Valiance, B. A., Li, Y., Puente, J. L. & Finlay, B. B. (2003). Citrobacter rodentium translocated intimin receptor (Tir) is an essential virulence factor needed for actin condensation, intestinal colonization and colonic hyperplasia in mice. Mol Microbiol 48, 95-115.
5. Donnenberg, M. S. & Kaper, J. B. (1991). Construction of an eae deletion mutant of enteropathogenic Escherichia coli by using a positive-selection suicide vector. Infiect Immun 59, 4310-4317.
6. Fitzhenry, R. J., Pickard, D. J., Hartland, E. L., Reece, S., Dougan, G., Phillips, A. D. & Frankel, G. (2002a). Intimin type influences the site of human intestinal mucosal colonisation by enterohaemorrhagic Escherichia coli O157: H7. Gut 50, 180-185.
7. Fitzhenry, R. J., Reece, S., Trabulsi, L. R., Heuschkel, R., Murch, S., Thomson, M., Frankel, G. & Phillips, A. D. (2002b). Tissue tropism of enteropathogenic Escherichia coli strains belonging to the O55 serogroup. Infect Immun 70, 4362-4368.
8. Frankel, G., Candy, D. C., Everest, P. & Dougan, G. (1994). haracterization of the C-terminal domains of intimin-like proteins of enteropathogenic and enterohemorrhagic Escherichia coli, Citrobacter freundii, and Hafnia alvei. Infect Immun 62, 1835-1842.
9. Frankel, G., Candy, D. C., Fabiani, E., Adu-Bobie, J., Gil, S., Novakova, M., Phillips, A. D. & Dougan, G. (1995). Molecular characterization of a carboxy-terminal eukaryotic-cell-binding domain of intimin from enteropathogenic Escherichia coli. Infect Immun 63, 4323-4328.
10. Frankel, G., Lider, O., Hershkoviz, R., Mould, A. P., Kachalsky, S. G., Candy, D. C. A., Cahalon, L., Humphries, M. J. & Dougan, G. (1996a). The cell-binding domain of intimin from enteropathogenic Escherichia coli binds to betal integrins. J Biol Chem 271, 20359-20364.
11. Frankel, G., Phillips, A. D., Novakova, M., Field, H., Candy, D. C., Schauer, D. B., Douce, G. & Dougan, G. (1996b). Intimin from enteropathogenic Escherichia coli restores murine virulence to a Citrobacter rodentium eaeA mutant: induction of an immunoglobulin A response to intimin and EspB. Infect Immun 64, 5315-5325.
12. Frankel, G., Philips, A. D., Novakova, M., Batchelor, M., Hicks, S. & Dougan, G. (1998). Generation of Escherichia coli intimin-derivatives with differing biological activities using site-directed mutagenesis of the intimin C-terminus domain. Mol Microbiol 29, 559-570.
13. Garmendia, J., Frankel, G. & Crepin, V. F. (2005). Enteropathogenic and enterohaemorrhagic E. coli infections: translocation, translocation, translocation. Infect Immun 73, 2586-2594.
14. Girard, F., Batisson, I., Frankel, G., Harel, J. & Fairbrother, J. M. (2005). Interaction of enteropathogenic and Shiga toxin-producing Escherichia coli and porcine intestinal mucosa: role of intimin and Tir in adherence. Infect Immun 73, 6005-6016.
15. Hartland, E. L., Huter, V., Higgins, L. M., Goncalves, N. S., Dougan, G., Phillips, A. D., MacDonald, T. T. & Frankel, G. (2000). Expression of intimin gamma from enterohemorrhagic Escherichia coli in Citrobacter rodentium. Infect Immun 68, 4637-4646.
16. Hicks, S., Frankel, G., Kaper, J. B., Dougan, G. & Phillips, A. D. (1998). Role of intimin and bundle forning pili in enteropathgenic Escherichia coli adhesion to paediatric intestine in vitro. Infect Immun 66, 1570-1578.
17. Jarvis, K. G., Giron, J. A., Jerse, A. E., McDaniel, T. K., Donnenberg, M. S. & Kaper, J. B. (1995). Enteropathogenic Escherichia coli contains a putative type III secretion system necessary for the export of proteins involved in attaching and effacing lesion formation. Proc Natl Acad Sci U S A 92, 7996-8000.
18. Jerse, A. E., Yu, J., Tall, B. D. & Kaper, J. B. (1990). A genetic locus of enteropathogenic Escherichia coli necessary for the production of attaching and effacing lesions on tissue culture cells. Proc Natl Acad Sci U S A 87, 7839-7843.
19. Kelly, G., Prasannan, S., Daniell, S., Flemming, K, Frankel, G., Dougan, G., Connerton, I. & Matthews, S. (1999). Intimin from enteropathogenic E. coli belongs to a new family of bacterial adhesion molecules containing C-type lectin- and tandem immunoglobulin-like domains. Nature Structural Biol 6, 313-318.
20. Kenny, B., DeVinney, R., Stein, M., Reinscheid, D. J., Frey, E. A. & Finlay, B. B. (1997). Enteropathogenic E. coli (EPEC) transfers its receptor for intimate adherence into mammalian cells. Cell 91, 511-520.
21. Luo, Y., Frey, E. A., Pfuetzner, R. A., Creagh, A. L., Knoechel, D. G., Haynes, C. A., Finlay, B. B. & Strynadka, N. C. (2000). Crystal structure of enteropathogenic Escherichia coli intimin-receptor complex. Nature 405, 1073-1077.
22. McDaniel, T. K, Jarvis, K. G., Donnenberg, M. S. & Kaper, J. B. (1995). A genetic locus of enterocyte effacement conserved among diverse enterobacterial pathogens. Proc Natl Acad Sci U S A 92, 1664-1668.
23. Mead, P. S., Slutsker, L., Griffin, P. M. & Tauxe, R. V. (1999). Food-related illness and death in the United States reply to Dr. Hedberg. Emerg Infect Dis 5, 841-842.
24. Mundy, R., MacDonald, T. T., Dougan, G., Frankel, G. & Wiles, S. (2005). Citrobacter rodentium of mice and man. Cell Microbiol 7, 1697-1706.
25. Nataro, J. P. & Kaper, J. B. (1998). Diarrheagenic Escherichia coli. Clin Microbiol Rev 11, 142-201.
26. Phillips, A. D. & Frankel, G. (2000). Intimin-mediated tissue specificity in enteropathogenic Escherichia coliinteraction with human intestinal organ cultures. J Infect Dis 181, 1496-1500.
27. Schauer, D. B. & Falkow, S. (1993). The eae gene of Citrobacter freundii biotype 4280 is necessary for colonization in transmissible murine colonic hyperplasia. Infect Immun 61, 4654-4661.
28. Sinclair, J. F. & O'Brien, A. D. (2004). Intimin types alpha, beta, and gamma bind to nucleolin with equivalent affinity but lower avidity than to the translocated intimin receptor. J Biol Chem 279, 33751-33758.
29. Thorpe, C. M. (2004). Shiga toxin-producing Escherichia coli infection. Clin Infect Dis 38, 1298-1303.
30. Tzipori, S., Gunzer, F., Donnenberg, M. S., de Montigny, L., Kaper, J. B. & Donohue-Rolfe, A. (1995). The role of the eaeA gene in diarrhea and neurological complications in a gnotobiotic piglet model of enterohemorrhagic Escherichia coli infection. Infect Immun 63, 3621-3627.