Are we finally taming inflammation?

Critical Care Medicine

Volumn 35, Issue 4, 2007, Pages 1215-1216

  Bojalil, Rafael ^a  

^a INSTITUTO NACIONAL DE CARDIOLOGÍA IGNACIO CHÁVEZ   (Mexico)

Author keywords

7 nicotinic acetylcholine receptor agonist; Cholinergic anti inflammatory pathway; Inflammation; Neuroimmunomodulation; Sepsis

Indexed keywords

3 (2,4 DIMETHOXYBENZYLIDENE)ANABASEINE; CD14 ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 12; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; NICOTINIC RECEPTOR; PROSTAGLANDIN E2; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

B LYMPHOCYTE; CHRONIC DISEASE; DIABETES MELLITUS; DIARRHEA; EDITORIAL; ENDOTHELIUM CELL; ENDOTOXEMIA; ENTERITIS; EPITHELIUM CELL; HOMEOSTASIS; IMMUNE RESPONSE; IN VITRO STUDY; IN VIVO STUDY; ISCHEMIC HEART DISEASE; KERATINOCYTE; LETHARGY; LIGATION; MESANGIUM CELL; NONHUMAN; PANCREATITIS; PERITONITIS; PRIORITY JOURNAL; PUNCTURE; RHEUMATOID ARTHRITIS; SEPSIS; SMOOTH MUSCLE FIBER; T LYMPHOCYTE; TH1 CELL; TH2 CELL; TISSUE INJURY; ULCERATIVE COLITIS; VAGUS REFLEX; VASCULAR SMOOTH MUSCLE;

ANIMALS; BENZYLIDENE COMPOUNDS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTOXEMIA; HMGB1 PROTEIN; INFLAMMATION; MICE; NF-KAPPA B; NICOTINIC AGONISTS; PYRIDINES; RECEPTORS, NICOTINIC; SEPSIS; SEVERITY OF ILLNESS INDEX; TUMOR NECROSIS FACTOR-ALPHA;

EID: 34247174014     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.CCM.0000259173.36272.28     Document Type: Editorial

References (15)

1. Pavlov VA, Ochani M, Yang LI: Selective α7-nicotinic acetylcholine receptor agonist GTS-21 improves survival in murine endotoxemia and severe sepsis. Crit Care Med 2007; 35:1139-1144
2. Pavlov VA, Tracey KJ: Controlling inflammation: The cholinergic anti-inflammatory pathway. Biochem Soc Trans 2006; 34:1037-1040
3. Ghia JE, Blennerhassett P, Kumar-Ondiveeran H, et al: The vagus nerve: A tonic inhibitory influence associated with inflammatory bowel disease in a murine model. Gastroenterology 2006; 131:1122-1130
4. van Westerloo DJ, Giebelen IA, Florquin S, et al: The cholinergic anti-inflammatory pathway regulates the host response during septic peritonitis. J Infect Dis 2005; 191:2138-2148
5. van Westerloo DJ, Giebelen IA, Florquin S, et al: The vagus nerve and nicotinic receptors modulate experimental pancreatitis severity in mice. Gastroenterology 2006; 130:1822-1830
6. Marquez-Velasco R, Bojalil R, Buelna A, et al: Anti-tumor necrosis factor α F(ab′)2 antibody fragments protect in murine polymicrobial sepsis: Concentration and early intervention are fundamental to the outcome. Inflamm Res 2006; 55:378-384
7. Borovikova LV, Ivanova S, Zhang M, et al: Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature 2000; 405:458-462
8. Yoshikawa H, Kurokawa M, Ozaki N, et al: Nicotine inhibits the production of proinflammatory mediators in human monocytes by suppression of I-kappaB phosphorylation and nuclear factor-kappaB transcriptional activity through nicotinic acetylcholine receptor alpha7. Clin Exp Immunol 2006; 146:116-123
9. Takahashi HK, Iwagaki H, Hamano R: α7 Nicotinic acetylcholine receptor stimulation inhibits lipopolysaccharide-induced interleukin-18 and -12 production in monocytes. J Pharmacol Sci 2006; 102:143-146
10. Hamano R, Takahashi HK, Iwagaki H, et al: Stimulation of alpha7 nicotinic acetylcholine receptor inhibits CD14 and the toll-like receptor 4 expression in human monocytes. Shock 2006; 26:358-364
11. van Westerloo DJ, Giebelen IA, Meijers JC, et al: Vagus nerve stimulation inhibits activation of coagulation and fibrinolysis during endotoxemia in rats. J Thromb Haemost 2006; 4:1997-2002
12. Kimura R, Ushiyama N, Fujii T, et al: Nicotine-induced Ca2+- signaling and down-regulation of nicotinic acetylcholine receptor subunit expression in the CEM human leukemic T-cell line. Life Sci 2003; 72:2155-2158
13. Jaimes E, Tian RX, Raij L: Nicotine: The link between cigarette smoking and the progression of renal injury? Am J Physiol Heart Circ Physiol 2007; 292:H76-H82
14. Li XW, Wang H: Non-neuronal nicotinic alpha 7 receptor, a new endothelial target for revascularization. Life Sci 2006; 78:1863-1870
15. Arredondo J, Chernyavsky AI, Jolkovsky DL, et al: Receptor-mediated tobacco toxicity: Cooperation of the Ras/Raf-1/MEK1/ERK and JAK-2/STAT-3 pathways downstream of alpha7 nicotinic receptor in oral keratinocytes. FASEB J 2006; 20:2093-2101