Multistep hepatocarcinogenesis from a dysplastic nodule to well-differentiated hepatocellular carcinoma in a patient with alcohol-related liver cirrhosis

World Journal of Gastroenterology

Volumn 13, Issue 8, 2007, Pages 1271-1274

  Kim, Soo Ryang ^a   Ikawa, Hirotsugu ^a   Ando, Kenji ^a   Mita, Keiji ^a   Fuki, Shuichi ^a   Sakamoto, Michiie ^b   Kanbara, Yoshihiro ^c   Matsuoka, Toshiyuki ^d   Kudo, Masatoshi ^e   Hayashi, Yoshitake ^f  

^a KOBE ASAHI HOSPITAL   (Japan)

^b KEIO UNIVERSITY   (Japan)

^c HYOGO MEDICAL CENTER FOR ADULTS   (Japan)

^d OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^e KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^f KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Alcohol related liver cirrhosis; Cyclase associated protein 2; Dysplastic nodule; Multistep hepatocarcinogenesis; Well differentiated hepatocellular carcinoma

Indexed keywords

CONTRAST MEDIUM; MOLECULAR MARKER;

ADULT; ALCOHOL LIVER CIRRHOSIS; ARTICLE; CANCER SIZE; CASE REPORT; CONTRAST ENHANCEMENT; ECHOGRAPHY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER BIOPSY; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; MALE; MALIGNANT TRANSFORMATION; TUMOR DIFFERENTIATION;

EID: 34247170510     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v13.i8.1271     Document Type: Article

References (11)

1. Terminology of nodular hepatocellular lesions. International Working Party. Hepatology 1995; 22: 983-993
2. Takayama T, Makuuchi M, Hirohashi S, Sakamoto M, Okazaki N, Takayasu K, Kesuge T, Motoo Y, Yamazaki S, Hasegawa H. Malignant transformation of adenomatous hyperplasia to hepatocellular carcinoma. Lancet 1990; 336: 1150-1153
3. Ikai I,, Itai Y, Okita K, Omata M, Kojiro M, Kobayashi K, Nakanuma Y, Futagawa S, Makuuchi M, Yamaoka Y. Report of the 15th follow-up survey of primary liver cancer. Hepatol Res 2004; 28: 21-29.
4. Morgan TR, Mandayam S, Jamal MM. Alcohol and hepatocellular cancinoma. Gastroenterology 2004; 127: S87-S96
5. Chuma M, Sakamoto M, Yamazaki K, Ohta T, Ohki M, Asaka M, Hirohashi S. Expression profiling in multistage hepatocarcinogenis: identification of HSP70 as a molecular marker of early hepatocellular carcinoma. Hepatology 2003; 37: 198-207
6. Shibata R, Mori T, Du W, Chuma M, Gotoh M, Shimazu M, Ueda M, Hirohashi S, Sakamoto M. Overexpression of cyclase-associated protein 2 in multistage hepatocarcinogenesis. Clin Cancer Res 2006; 12: 5363-5368
7. Sakamoto M, Hirohashi S, Shimosato Y. Early stages of multistep hepatocarcinogenesis: adenomatous hyperplasia and early hepatocellular carcinoma. Hum Pathol 1991; 22: 172-178
8. Kojiro M, Shigetaka S, Nakashima O. Pathomorphologic characteristics of early hepatocellular carcinoma. In: Okuda K, Tobe T, Kitagawa T, editors. Early detection and treatment of liver cancer. Gann Monogr Cancer Res 1991; 38: 29-37
9. Nakashima O, Watanabe J, Tanaka M, Fukukura Y, Kojiro M, Kurohiji T, Saitsu H, Adachi A, Nabeshima M, Miura K. Clinicopathologic study of hyperplastic nodules in patient with chronic alcoholic liver disease. Kanzo 1996; 37: 704-713
10. Kita R, Osaki Y, Maruo T, Kimura T, Kokuryu H, Takamatsu S, Tomono N, Shimizu T. A case of severe alcoholic liver cirrhosis with multiple hyperplastic nodules. Kanzo 2001; 42: 203-209
11. Nagasue N, Akamizu H, Yukaya H, Yuuki I. Hepatocellular pseudotumor in the cirrhotic liver. Report of three cases. Cancer 1984; 54: 2487-2494