Effects of estrogen receptor subtype-selective agonists on autoimmune disease in lupus-prone NZB/NZW F1 mouse model

Clinical Immunology

Volumn 123, Issue 2, 2007, Pages 219-226

  Li, Jing ^a   McMurray, Robert W ^b  

^a CHINA MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

Author keywords

Albuminuria; Anti DNA antibody; Autoimmunity; DPN; Estrogen receptor; Lupus; PPT; Prolactin; Subtype selective agonist; Survival

Indexed keywords

DNA ANTIBODY; ESTROGEN; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; HORMONE RECEPTOR STIMULATING AGENT; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G1 ANTIBODY; IMMUNOGLOBULIN G2A ANTIBODY; IMMUNOGLOBULIN G2B; IMMUNOGLOBULIN G3; IMMUNOGLOBULIN SUBCLASS; PROLACTIN; PROPIONITRILE; PROPYL PYRAZOLE TRIOL; UNCLASSIFIED DRUG;

ALBUMINURIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; DRUG SELECTIVITY; FEMALE; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOSTIMULATION; LUPUS ERYTHEMATOSUS; MOUSE; NONHUMAN; OVARIECTOMY; PRIORITY JOURNAL; PROLACTIN BLOOD LEVEL; RECEPTOR UPREGULATION; SURVIVAL;

ALBUMINURIA; ANIMALS; ANTIBODIES, ANTINUCLEAR; BLOOD UREA NITROGEN; BODY WEIGHT; DISEASE MODELS, ANIMAL; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FEMALE; IMMUNE SYSTEM; IMMUNOGLOBULIN G; IMMUNOLOGIC FACTORS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MICE; MICE, INBRED NZB; NITRILES; OVARIECTOMY; PROLACTIN; PROPIONATES; PYRAZOLES; RECEPTORS, ESTROGEN; SURVIVAL ANALYSIS;

EID: 34247169508     PISSN: 15216616     EISSN: 15217035     Source Type: Journal    
DOI: 10.1016/j.clim.2007.01.008     Document Type: Article

References (45)

1. McMurray R.W. Estrogen, prolactin, and autoimmunity: actions and interactions. Int. Immunopharmacol. 1 (2001) 995-1008
2. Imamov O., Shim G.J., Warner M., and Gustafsson J.A. Estrogen receptor beta in health and disease. Biol. Reprod. 73 (2005) 866-871
3. Kawashima I., Seiki K., Sakabe K., Ihara S., Akatsuka A., and Katsumata Y. Localization of estrogen receptors and estrogen receptor-mRNA in female mouse thymus. Thymus 20 (1992) 115-121
4. Tornwall J., Carey A.B., Fox R.I., and Fox H.S. Estrogen in autoimmunity: expression of estrogen receptors in thymic and autoimmune T cells. J. Gend.-Specif. Med. 2 (1999) 33-40
5. Smithson G., Couse J.F., Lubahn D.B., Korach K.S., and Kincade P.W. The role of estrogen receptors and androgen receptors in sex steroid regulation of B lymphopoiesis. J. Immunol. 161 (1998) 27-34
6. Samy T.S., Zheng R., Matsutani T., Rue III L.W., Bland K.I., and Chaudry I.H. Mechanism for normal splenic T lymphocyte functions in proestrus females after trauma: enhanced local synthesis of 17 beta-estradiol. Am. J. Physiol.: Cell Physiol. 285 (2003) C139-C149
7. Yurino H., Ishikawa S., Sato T., Akadegawa K., Ito T., Ueha S., Inadera H., and Matsushima K. Endocrine disruptors (environmental estrogens) enhance autoantibody production by B1 cells. Toxicol. Sci. 81 (2004) 139-147
8. Grimaldi C.M., Cleary J., Dagtas A.S., Moussai D., and Diamond B. Estrogen alters thresholds for B cell apoptosis and activation. J. Clin. Invest. 109 (2002) 1625-1633
9. Paharkova-Vatchkova V., Maldonado R., and Kovats S. Estrogen preferentially promotes the differentiation of CD11c+CD11b (intermediate) dendritic cells from bone marrow precursors. J. Immunol. 172 (2004) 1426-1436
10. Reeves W.H., and Lahita R.B. Clinical presentation of systemic lupus erythematosus in the adult. In: Lahita R.G. (Ed). Systemic Lupus Erythematosus (1992), Churchill Livingston, New York 369-396
11. Theofilopoulos A.N. Murine models of lupus. In: Lahita R.G. (Ed). Systemic Lupus Erythematosus (1992), Churchill Livingstone, New York 121-194
12. Lahita R.G. Sex, age, and systemic lupus erythematosus. In: Lahita R.G. (Ed). Systemic Lupus Erythematosus (1992), Churchill Livingstone, New York 527-542
13. Roubinian J.R., Talal N., Greenspan J.S., Goodman J.R., and Siiteri P.K. Effect of castration and sex hormone treatment on survival, anti-nucleic acid antibodies, and glomerulonephritis in NZB/NZW F1 mice. J. Exp. Med. 147 (1978) 1568-1583
14. Johansson M., Arlestig L., Moller B., Smedby T., and Rantapaa-Dahlqvist S. Oestrogen receptor {alpha} gene polymorphisms in systemic lupus erythematosus. Ann. Rheum. Dis. 64 (2005) 1611-1617
15. Lee Y.J., Shin K.S., Kang S.W., Lee C.K., Yoo B., Cha H.S., Koh E.M., Yoon S.J., and Lee J. Association of the oestrogen receptor alpha gene polymorphisms with disease onset in systemic lupus erythematosus. Ann. Rheum. Dis. 63 (2004) 1244-1249
16. Chang M., Lubahn D.B., and Hoffman R.W. DNA microsatellite markers for estrogen receptor-beta are not associated with systemic lupus erythematosus. J. Rheumatol. 28 (2001) 924-925
17. Kassi E.N., Vlachoyiannopoulos P.G., Moutsopoulos H.M., Sekeris C.E., and Moutsatsou P. Molecular analysis of estrogen receptor alpha and beta in lupus patients. Eur. J. Clin. Invest. 31 (2001) 86-93
18. Suenaga R., Evans M.J., Mitamura K., Rider V., and Abdou N.I. Peripheral blood T cells and monocytes and B cell lines derived from patients with lupus express estrogen receptor transcripts similar to those of normal cells. J. Rheumatol. 25 (1998) 1305-1312
19. Suenaga R., Rider V., Evans M.J., and Abdou N.I. In vitro-activated human lupus T cells express normal estrogen receptor proteins which bind to the estrogen response element. Lupus 10 (2001) 116-122
20. Li J., and McMurray R.W. Effects of estrogen receptor subtype-selective agonists on immune functions in ovariectomized mice. Int. Immunopharmacol. 6 (2006) 1413-1423
21. Elloso M.M., Phiel K., Henderson R.A., Harris H.A., and Adelman S.J. Suppression of experimental autoimmune encephalomyelitis using estrogen receptor-selective ligands. J. Endocrinol. 185 (2005) 243-252
22. Hildebrand F., Hubbard W.J., Choudhry M.A., Thobe B.M., Pape H.C., and Chaudry I.H. Are the protective effects of 17{beta}-estradiol on splenic macrophages and splenocytes after trauma-hemorrhage mediated via estrogen-receptor (ER)-{alpha} or ER-{beta}?. J. Leukocyte Biol. 79 (2006) 1173-1180
23. Follettie M.T., Pinard M., Keith Jr. J.C., Wang L., Chelsky D., Hayward C., Kearney P., Thibault P., Paramithiotis E., Dorner A.J., and Harris H.A. Organ messenger ribonucleic acid and plasma proteome changes in the adjuvant-induced arthritis model: responses to disease induction and therapy with the estrogen receptor-beta selective agonist ERB-041. Endocrinology 147 (2006) 714-723
24. Stauffer S.R., Coletta C.J., Tedesco R., Nishiguchi G., Carlson K., Sun J., Katzenellenbogen B.S., and Katzenellenbogen J.A. Pyrazole ligands: structure-affinity/activity relationships and estrogen receptor-alpha-selective agonists. J. Med. Chem. 43 (2000) 4934-4947
25. Meyers M.J., Sun J., Carlson K.E., Marriner G.A., Katzenellenbogen B.S., and Katzenellenbogen J.A. Estrogen receptor-beta potency-selective ligands: structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogues. J. Med. Chem. 44 (2001) 4230-4251
26. Frasor J., Barnett D.H., Danes J.M., Hess R., Parlow A.F., and Katzenellenbogen B.S. Response-specific and ligand dose-dependent modulation of estrogen receptor (ER) alpha activity by ERbeta in the uterus. Endocrinology 144 (2003) 3159-3166
27. Sanchez-Criado J.E., Martin De Las Mulas J., Bellido C., Tena-Sempere M., Aguilar R., and Blanco A. Biological role of pituitary estrogen receptors ERalpha and ERbeta on progesterone receptor expression and action and on gonadotropin and prolactin secretion in the rat. Neuroendocrinology 79 (2004) 247-258
28. Walf A.A., Rhodes M.E., and Frye C.A. Antidepressant effects of ERbeta-selective estrogen receptor modulators in the forced swim test. Pharmacol. Biochem. Behav. 78 (2004) 523-529
29. Booth E.A., Obeid N.R., and Lucchesi B.R. Activation of estrogen receptor alpha protects the in vivo rabbit heart from ischemia-reperfusion injury. Am. J. Physiol.: Heart Circ. Physiol. 289 (2005) H2039-H2047
30. McMurray R., Keisler D., Kanuckel K., Izui S., and Walker S.E. Prolactin influences autoimmune disease activity in the female B/W mouse. J. Immunol. 147 (1991) 3780-3787
31. Carlsten H., Tarkowski A., Holmdahl R., and Nilsson L.A. Oestrogen is a potent disease accelerator in SLE-prone MRL lpr/lpr mice. Clin. Exp. Immunol. 80 (1990) 467-473
32. Elbourne K.B., Keisler D., and McMurray R.W. Differential effects of estrogen and prolactin on autoimmune disease in the NZB/NZW F1 mouse model of systemic lupus erythematosus. Lupus 7 (1998) 420-427
33. Sthoeger Z.M., Zinger H., and Mozes E. Beneficial effects of the anti-oestrogen tamoxifen on systemic lupus erythematosus of (NZBxNZW)F1 female mice are associated with specific reduction of IgG3 autoantibodies. Ann. Rheum. Dis. 62 (2003) 341-346
34. Brick J.E., Ong S.H., Bathon J.M., Walker S.E., O'Sullivan F.X., and DiBartolomeo A.G. Anti-histone antibodies in the serum of autoimmune MRL and NZB/NZW1 F1 mice. Clin. Immunol. Immunopathol. 54 (1990) 372-381
35. Scully K.M., Gleiberman A.S., Lindzey J., Lubahn D.B., Korach K.S., and Rosenfeld M.G. Role of estrogen receptor-alpha in the anterior pituitary gland. Mol. Endocrinol. 11 (1997) 674-681
36. Pelletier G., Li S., Phaneuf D., Martel C., and Labrie F. Morphological studies of prolactin-secreting cells in estrogen receptor alpha and estrogen receptor beta knockout mice. Neuroendocrinology 77 (2003) 324-333
37. Shim G.J., Kis L.L., Warner M., and Gustafsson J.A. Autoimmune glomerulonephritis with spontaneous formation of splenic germinal centers in mice lacking the estrogen receptor alpha gene. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 1720-1724
38. Shim G.J., Wang L., Andersson S., Nagy N., Kis L.L., Zhang Q., Makela S., Warner M., and Gustafsson J.A. Disruption of the estrogen receptor beta gene in mice causes myeloproliferative disease resembling chronic myeloid leukemia with lymphoid blast crisis. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 6694-6699
39. Murakami M., Tsubata T., Okamoto M., Shimizu A., Kumagai S., Imura H., and Honjo T. Antigen-induced apoptotic death of Ly-1 B cells responsible for autoimmune disease in transgenic mice. Nature 357 (1992) 77-80
40. Haas C., Ryffel B., and Le Hir M. IFN-gamma is essential for the development of autoimmune glomerulonephritis in MRL/Ipr mice. J. Immunol. 158 (1997) 5484-5491
41. Santiago M.L., Fossati L., Jacquet C., Muller W., Izui S., and Reininger L. Interleukin-4 protects against a genetically linked lupus-like autoimmune syndrome. J. Exp. Med. 185 (1997) 65-70
42. Zhang Q.H., Cao J., Hu Y.Z., Huang Y.H., Lu S.Y., Wei G.Z., and Zhao Y.F. Morphological observation of immunological alterations in the spleens from estrogen receptor deficient mice. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 20 (2004) 1-6
43. Stossi F., Barnett D.H., Frasor J., Komm B., Lyttle C.R., and Katzenellenbogen B.S. Transcriptional profiling of estrogen-regulated gene expression via estrogen receptor (ER) alpha or ERbeta in human osteosarcoma cells: distinct and common target genes for these receptors. Endocrinology 145 (2004) 3473-3486
44. McIntyre T.M., Klinman D.R., Rothman P., Lugo M., Dasch J.R., Mond J.J., and Snapper C.M. Transforming growth factor beta 1 selectivity stimulates immunoglobulin G2b secretion by lipopolysaccharide-activated murine B cells. J. Exp. Med. 177 (1993) 1031-1037
45. Nozaki Y., Yamagata T., Yoo B.S., Sugiyama M., Ikoma S., Kinoshita K., Funauchi M., and Kanamaru A. The beneficial effects of treatment with all-trans-retinoic acid plus corticosteroid on autoimmune nephritis in NZB/WF mice. Clin. Exp. Immunol. 139 (2005) 74-83