Acid sphingomyelinase is required for lipid raft TLR4 complex formation

Surgical Infections

Volumn 8, Issue 1, 2007, Pages 91-105

  Cuschieri, Joseph ^a,b   Bulger, Eileen ^a   Billgrin, Jens ^a   Garcia, Iris ^a   Maier, Ronald V ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD14 ANTIGEN; CERAMIDE; IMIPRAMINE; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; NEUTRALIZING ANTIBODY; PROTEIN KINASE C ZETA; SPHINGOMYELIN PHOSPHODIESTERASE; SPHINGOMYELIN PHOSPHODIESTERASE INHIBITOR; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CELL STIMULATION; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; LIPID RAFT; PRIORITY JOURNAL;

ANTIGENS, CD14; CELL LINE, TUMOR; CERAMIDES; ENZYME INHIBITORS; HUMANS; IMIPRAMINE; LIPOPOLYSACCHARIDES; MEMBRANE MICRODOMAINS; MICROSCOPY, CONFOCAL; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; PHOSPHORYLATION; PROTEIN KINASE C; SPHINGOMYELIN PHOSPHODIESTERASE; TOLL-LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR-ALPHA;

EID: 34247166203     PISSN: 10962964     EISSN: None     Source Type: Journal    
DOI: 10.1089/sur.2006.050     Document Type: Article

References (34)

1. Hurley JC. Endotoxemia and gram-negative bacteremia as predictors of outcome in sepsis: A meta-analysis using ROC curves. J Endotoxin Res 2003;9: 271-279.
2. Dellinger RP, Carlet JM, Masur H, et al. Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Intensive Care Med 2004;30:536-555.
3. Alexander C, Rietschel ET. Bacterial lipopolysaccharides and innate immunity. J Endotoxin Res 2001;7: 167-202.
4. Finberg RW, Re F, Popova L, et al. Cell activation by Toll-like receptors: Role of LBP and CD14. J Endotoxin Res 2004;10:413-418.
5. Triantafilou M, Miyake K, Golenbock DT, et al. Mediators of innate immune recognition of bacteria concentrate in lipid rafts and facilitate lipopolysaccharide-induced cell activation. J Cell Sci 2002;115: 2603-2611.
6. Cuschieri J, Umanskiy K, Solomkin J. PKC-zeta is essential for endotoxin-induced macrophage activation. J Surg Res 2004;121:76-83.
7. Wang YM, Seibenhener ML, Vandenplas ML, et al. Atypical PKC zeta is activated by ceramide, resulting in coactivation of NF-kappaB/JNK kinase and cell survival. J Neurosci Res 1999;55:293-302.
8. Monick MM, Mallampalli RK, Carter AB, et al. Ceramide regulates lipopolysaccharide-induced phosphatidylinositol 3-kinase and Akt activity in human alveolar macrophages. J Immunol 2001;167:5977-5985.
9. Pfeiffer A, Bottcher A, Orso E, et al. Lipopolysaccharide and ceramide docking to CD14 provokes ligand-specific receptor clustering in rafts. Eur J Immunol 2001;31:3153-3164.
10. Kolesnick R. Signal transduction through the sphingomyelin pathway. Mol Chem Neuropathol 1994;21: 287-297.
11. Abdel Shakor AB, Kwiatkowska K, Sobota A. Cell surface ceramide generation precedes and controls FcγRII clustering and phosphorylation in rafts. J Biol Chem 2004;279:36778-36787.
12. Merrill AH Jr, Wang E. Biosynthesis of long-chain (sphingoid) bases from serine by LM cells: Evidence for introduction of the 4-trans-double bond after de novo biosynthesis of N-acylsphinganine(s). J Biol Chem 1986;261:3764-3769.
13. Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purification. Can J Biochem Physiol 1959;37:911-917.
14. Merrill AH Jr, Wang E, Mullins RE, et al. Quantitation of free sphingosine in liver by high-performance liquid chromatography. Anal Biochem 1988;171:373-381.
15. Pinsky MR. Dysregulation of the immune response in severe sepsis. Am J Med Sci 2004;328:220-229.
16. Dai Q, Zhang J, Pruett SB. Ethanol alters cellular activation and CD14 partitioning in lipid rafts. Biochem Biophys Res Commun 2005;332:37-42.
17. Gekara NO, Weiss S. Lipid rafts clustering and signalling by listeriolysin O. Biochem Soc Trans 2004; 32:712-714.
18. Radeva G, Sharom FJ. Isolation and characterization of lipid rafts with different properties from RBL-2H3 (rat basophilic leukaemia) cells. Biochem J 2004; 380:219-230.
19. Young RM, Holowka D, Baird B. A lipid raft environment enhances Lyn kinase activity by protecting the active site tyrosine from dephosphorylation. J Biol Chem 2003;278:20746-29752.
20. Meng F, Lowell CA. Lipopolysaccharide (LPS)-induced macrophage activation and signal transduction in the absence of Src-family kinases Hck, Fgr, and Lyn. J Exp Med 1997;185:1661-1670.
21. Fitzgerald KA, Rowe DC, Golenbock DT. Endotoxin recognition and signal transduction by the TLR4/MD2-complex. Microbes Infect 2004;6: 1361-1367.
22. Ghosh S, Bhattacharyya S, Das S, et al. Generation of ceramide in murine macrophages infected with Leishmania donovani alters macrophage signaling events and aids intracellular parasitic survival. Mol Cell Biochem 2001;223:47-60.
23. Schwende H, Fitzke E, Ambs P, et al. Differences in the state of differentiation of THP-1 cells induced by phorbol ester and 1,25- dihydroxyvitamin D3. J Leukoc Biol 1996;59:555-561.
24. Falcone S, Perrotta C, De Palma C, et al. Activation of acid sphingomyelinase and its inhibition by the nitric oxide/cyclic guanosine 3′,5′-monophosphate pathway: Key events in Escherichia coli-elicited apoptosis of dendritic cells. J Immunol 2004;173: 4452-4463.
25. Balsinde J, Balboa MA, Dennis EA. Inflammatory activation of arachidonic acid signaling in murine P388D1 macrophages via sphingomyelin synthesis. J Biol Chem 1997;272:20373-20377.
26. Pahan K, Sheikh FG, Khan M, et al. Sphingomyelinase and ceramide stimulate the expression of inducible nitric-oxide synthase in rat primary astrocytes. J Biol Chem 1998;273:2591-2600.
27. Claus RA, Bunck AC, Bockmeyer CL, et al. Role of increased sphingomyelinase activity in apoptosis and organ failure of patients with severe sepsis. FASEB J 2005;19:1719-1721.
28. Monick MM, Carter AB, Gudmundsson G, et al. A phosphatidylcholine- specific phospholipase C regulates activation of p42/44 mitogen-activated protein kinases in lipopolysaccharide-stimulated human alveolar macrophages. J Immunol 1999;162:3005-3012.
29. MacKichan ML, DeFranco AL. Role of ceramide in lipopolysaccharide (LPS)-induced signaling: LPS increases ceramide rather than acting as a structural homolog. J Biol Chem 1999;274:1767-1775.
30. Medvedev AE, Blanco JC, Qureshi N, et al. Limited role of ceramide in lipopolysaccharide-mediated mitogen-activated protein kinase activation, transcription factor induction, and cytokine release. J Biol Chem 1999;274:9342-9350.
31. Procyk KJ, Rippo MR, Testi R, et al. Lipopolysaccharide induces jun N-terminal kinase activation in macrophages by a novel Cdc42/Rac-independent pathway involving sequential activation of protein kinase C zeta and phosphatidylcholine-dependent phospholipase C. Blood 2000;96:2592-2598.
32. Koide N, Sugiyama T, Mori I, et al. C2-ceramide inhibits LPS-induced nitric oxide production in RAW 264.7 macrophage cells through down-regulating the activation of Akt. J Endotoxin Res 2003;9:85-90.
33. Goggel R, Winoto-Morbach S, Vielhaber G, et al. PAF-mediated pulmonary edema: A new role for acid sphingomyelinase and ceramide. Nat Med 2004;10: 155-160.
34. Steinbrecher UP, Gomez-Munoz A, Duronio V. Acid sphingomyelinase in macrophage apoptosis. Curr Opin Lipidol 2004;15:531-537.