rpoN gene of Pseudomonas aeruginosa alters its susceptibility to quinolones and carbapenems

Antimicrobial Agents and Chemotherapy

Volumn 51, Issue 4, 2007, Pages 1455-1462

  Viducic, Darija ^a,b   Ono, Tsuneko ^a   Murakami, Keiji ^a   Katakami, Mikiko ^a   Susilowati, Heni ^a   Miyake, Yoichiro ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIAPENEM; CIPROFLOXACIN; GREEN FLUORESCENT PROTEIN; IMIPENEM; OFLOXACIN; PYOVERDINE; SIGMA FACTOR RPON;

ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GENE; BACTERIAL GROWTH; BACTERIAL SURVIVAL; BACTERIUM CULTURE; BACTERIUM MUTANT; CULTURE MEDIUM; FLOW CYTOMETRY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PSEUDOMONAS AERUGINOSA; PVDS GENE; QUANTITATIVE ASSAY; REACTION ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RPON GENE; SURVIVAL RATE; SYNTHESIS; VQSR GENE;

CARBAPENEMS; GENE EXPRESSION REGULATION, BACTERIAL; GENES, BACTERIAL; PROMOTER REGIONS (GENETICS); PSEUDOMONAS AERUGINOSA; QUINOLONES; RNA POLYMERASE SIGMA 54; TRANSCRIPTION, GENETIC; VIRULENCE;

EID: 34247154268     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.00348-06     Document Type: Article

References (26)

1. N in environmental stress survival of Pseudomonas putida. FEMS Microbiol. Ecol. 35:217-221.
2. 54) in Pseudomonas aeruginosa PAO1. J. Bacteriol. 185:2227-2235.
3. Hohnadel, D., D. Haas, and J.-M. Meyer. 1986. Mapping of mutations affecting pyoverdine production in Pseudomonas aeruginosa. FEMS Microbiol. Lett. 36:195-199.
4. Jovanovic, M., M. Lilic, R. Janjusevic, G. Jovanovic, and D. J. Savic. 1999. tRNA synthetase mutants of Escherichia coli K-12 are resistant to the gyrase inhibitor novobiocin. J. Bacteriol. 181:2979- 2983.
5. Juhas, M., L. Wiehlmann, B. Huber, D. Jordan, J. Lauber, P. Salunkhe, A. S. Limpert, F. von Gotz, I. Steinmetz, L. Eberl, and B. Tümmler. 2004. Global regulation of quorum sensing and virulence by VqsR in Pseudomonas aeruginosa. Microbiology 150:831-841.
6. Juhas, M., L. Wiehlmann, P. Salunkhe, J. Lauber, J. Buer, and B. Tümmler. 2005. GeneChip expression analysis of the VqsR regulon of Pseudomonas aeruginosa TB. FEMS Microbiol. Lett. 242:287-295.
7. Lamont, I. L., P. A. Beare, U. Ochsner, A. I. Vasil, and M. L. Vasil. 2002. Siderophore-mediated signaling regulates virulence factor production in Pseudomonas aeruginosa. Proc. Natl. Acad. Sci. USA 99:7072-7077.
8. 54. Mol. Microbiol. 36:940-954.
9. Merrell, D. S., L. J. Thompson, C. C. Kim, H. Mitchell, L. S. Tompkins, A. Lee, and S. Falkow. 2003. Growth phase-dependent response of Helicobacter pylori to iron starvation. Infect. Immun. 71:6510-6525.
10. Miyake, Y., S. Fujiwara, T. Usui, and H. Suginaka. 1992. Simple method for measuring the antibiotic concentration required to kill adherent bacteria. Chemotherapy 38:286-290.
11. Murakami, K., T. Ono, D. Viducic, S. Kayama, M. Mori, K. Hirota, K. Nemoto, and V. Miyake. 2005. Role for rpoS gene of Pseudomonas aeruginosa in antibiotic tolerance. FEMS Microbiol. Lett. 242:161-167.
12. Novick, R. P. 2003. Autoinduction and signal transduction in the regulation of staphylococcal virulence. Mol. Microbiol. 48:1429-1449.
13. Ohman, E. D., S. J. Cryz, and B. H. Iglewski. 1980. Isolation and characterization of a Pseudomonas aeruginosa PAO mutant that produces altered elastase. J. Bacteriol. 142:836-842.
14. Poole, K., D. E. Heinrichs, and S. Neshat. 1993. Cloning and sequence analysis of an EnvCD homologue in Pseudomonas aeruginosa: regulation by iron and possible involvement in the secretion of the siderophore pyoverdine. Mol. Microbiol. 10:529-544.
15. Powell, B. S., and C. L. Court. 1998. Control of ftsZ expression, cell division, and glutamine metabolism in Luria-Bertani medium by the alarmone ppGpp in Escherichia coli. J. Bacteriol. 180:1053-1062.
16. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
17. Schweizer, H. P. 1993. Small broad-host-range gentamicin resistance gene cassettes for site-specific insertion and deletion mutagenesis. BioTechniques 15:831-834.
18. Schweizer, H. P. 1992. Allelic exchange in Pseudomonas aeruginosa using novel Co1E1-rype vectors and a family of cassettes containing a portable oriT and the counter-selectable Bacillus subtilis sacB marker. Mol. Microbiol. 6:1195-1204.
19. Simon, R., U. Priefer, and A. Puhler. 1983. A broad host range mobilization system for in vivo genetic engineering transposon mutagenesis in gram negative bacteria. Bio/Technology 1:784-791.
20. Smith, A. W., and B. H. Iglewski. 1989. Transformation of Pseudomonas aeruginosa by electroporation. Nucleic Acids Res. 17:10509.
21. Stintzi, A., K. Evans, J.-M. Meyer, and K. Poole. 1998. Quorum-sensing and siderophore biosynthesis in Pseudomonas aeruginosa: lasR/lasI mutants exhibit reduced pyoverdine biosynthesis. FEMS Microbiol. Lett. 166:341-345.
22. Thompson, L. S., J. S. Webb, S. A. Rice, and S. Kjelleberg. 2003. The alternative sigma factor RpoN regulates the quorum sensing gene rhlI in Pseudomonas aeruginosa. FEMS Microbiol. Lett. 220:187-195.
23. Tomasz, A., A. Albino, and E. Zanati. 1970. Multiple antibiotic resistance in a bacterium with suppressed autolytic system. Nature 227:138-140.
24. Totten, P. A., J. C. Lara, and S. Lory. 1990. The rpoN gene product of Pseudomonas aeruginosa is required for expression of diverse genes, including the flagellin gene. J. Bacteriol. 172:389-396.
25. Viducic, D., T. One, K. Murakami, H. Susilowati, S. Kayama, K. Hirota, and Y. Miyake. 2006. Functional analysis of spoT, relA and dksA genes on quinolone tolerance in Pseudomonas aeruginosa under nongrowing condition. Microbiol. Immunol. 50:349-357.
26. Woods, D. E., D. C. Straus, W. G. Johanson, Jr., W. K. Berry, and J. A. Bass. 1980. Role of pili in adherence of Pseudomonas aeruginosa to mammalian buccal epithelial cells. Infect. Immun. 29:1146-1151.