Preparation of budesonide-poly (ethylene oxide) solid dispersions using supercritical carbon dioxide and in vitro evaluation

Yaoxue Xuebao

Volumn 42, Issue 2, 2007, Pages 206-210

  Liu, Hui ^a,b   Pan, Wei San ^a   Zhou, Li Li ^a   Zhang, Zhi Hong ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b WUHAN GENERAL HOSPITAL OF GUANGZHOU COMMAND   (China)

Author keywords

Budesonide; Poly (ethylene oxide); Solid dispersion; Supercritical fluid

Indexed keywords

BUDESONIDE; CARBON DIOXIDE; DRUG CARRIER; ETHYLENE OXIDE;

ARTICLE; CHEMISTRY; DIFFERENTIAL SCANNING CALORIMETRY; METHODOLOGY; POWDER; PRESSURE; SOLUBILITY; SUPERCRITICAL FLUID CHROMATOGRAPHY; TEMPERATURE; WETTABILITY; X RAY DIFFRACTION;

BUDESONIDE; CALORIMETRY, DIFFERENTIAL SCANNING; CARBON DIOXIDE; CHROMATOGRAPHY, SUPERCRITICAL FLUID; DRUG CARRIERS; ETHYLENE OXIDE; POWDERS; PRESSURE; SOLUBILITY; TEMPERATURE; WETTABILITY; X-RAY DIFFRACTION;

EID: 34247139691     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (7)

1. Broman E, Khoo C, Taylor LS. A comparison of alternative polymer excipients and processing methods for making solid dispersions of poorly water-soluble drug [J]. Int J Pharm, 2001, 222:139-151.
2. Li FQ, Hu JH, Wang H, et al. Relativities between lattice changes and the function of dissolution improvement of poorly soluble drug silymarin based upon PEG 6 000 solid dispersion system [J]. Acta Pharm Sin, 2002, 37:294-298.
3. Van Nijlen T, Brennan K, Van den Mooter G, et al. Improvement of the dissolution rate of artemisinin by means of supercritical fluid technology and solid dispersions [J]. Int J Pharm, 2003, 254:173-181.
4. 2 [J]. Int J Pharm, 1997, 148:123-130.
5. Sethia S, Squillante E. Solid dispersion of carbamazepine in PVP K30 by conventional solvent evaporation and supercritical methods [J]. Int J Pharm, 2004, 272:1-10.
6. Edward JOC. Review of the unique properties of budesonide [J]. Clin Ther, 2003, 25:C42 - C60.
7. Cui JH, Yan YD, Guo JP, et al. Studies on the preparation and release in vitro of budesonide pulsatile controlled release tablet of colon-specific delivery [J]. Pharm J Chin PLA, 2004, 6:418-421.