Relativities between lattice changes and the function of dissolution improvement of poorly soluble drug silymarin based upon PEG 6 000 solid dispersion system

Yaoxue Xuebao

Volumn 37, Issue 4, 2002, Pages 294-298

  Li, Feng Qian ^a   Hu, Jin Hong ^a   Wang, Hui ^a   Zhu, Quan Gang ^a   Sun, Hua Jun ^a   Cai, Zhen ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Dissolution; PEG 6 000; Poorly soluble drugs; Silymarin; Solid dispersion system; X ray powder diffraction

Indexed keywords

DRUG CARRIER; MACROGOL DERIVATIVE; SILYMARIN;

ARTICLE; CHEMISTRY; CRYSTALLIZATION; SOLUBILITY; X RAY CRYSTALLOGRAPHY;

CHEMISTRY, PHARMACEUTICAL; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; DRUG CARRIERS; POLYETHYLENE GLYCOLS; SILYMARIN; SOLUBILITY;

EID: 0041881954     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Sun TM, Li X. Advances in pharmacological studies of silymarin [J]. Chin Tradit Herb Drugs, 2000,31 (3):229-231.
2. Kai T, Akiyama Y, Nomura S, et al. Oral absorption improvement of poorly soluble drug using solid dispersion techniques [J]. Chem Pharm Bull, 1996,44(3):568-571.
3. Zhou GD, Duan LY. Basis of Structural Chemistry: Crystalline Lattice Structure and Characteristics [M]. 2nd Ed. Beijing: Peking University Press, 1995.328-378.
4. Damian F, Blaton N, Naesens L, et al. Physiochemical characterization of solid dispersion of the antiviral agent UC-781 with polyethylene glycol 6 000 and gelucire [J]. Eur J Pharm Sci, 2000,10(4):311-322.
5. Yamamura S, Momose Y. Quantitative analysis of crystalline pharmaceutical in powders and tablets by a pattern-fitting procedure using X-ray powder diffraction data [J]. Int J Pharm, 2001,212(2):203-212.
6. Fukuoka E, Terada K, Makita M, et al. Prefered orietation of crystallitesin tablets. V. pattern-fitting procedure for the determination of strength of preferred orientation of crystallites [J]. Chem Pharm Bull, 1993,41(9):1636-1639.
7. Higuchi T, Connors KA. Phase-solubility techniques [J]. Adv Anal Chem Instrum, 1965,4(2):117-210.
8. Hu G, Yang JX, Yun GX. Study on the solid dispersion of acyclovir [J]. Chin J Hosp Pharm, 1995,15(3):115-116.
9. Tanninen VP, Yliruusi Y. X-ray powder diffraction profile fitting in quantitative determination of two polymorphs from their powder mixture [J]. Int J Pharm , 1992,81(2):169-177.
10. Hancock BC, Zografi G. Characteristics and significance of the amorphous state in pharmaceutical system [J]. J Pharm Sci, 1997,86(1):1-12.