Behavioural phenotyping of sodium-myo-inositol cotransporter heterozygous knockout mice with reduced brain inositol

Genes, Brain and Behavior

Volumn 6, Issue 3, 2007, Pages 253-259

  Shaldubina, A ^a   Buccafusca, R ^b   Johanson, R A ^b   Agam, G ^a   Belmaker, R H ^a,c   Berry, G T ^b   Bersudsky, Y ^a  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c MENTAL HEALTH CENTER   (Israel)

Author keywords

Animal models of psychiatric disorders; Anxiety; Behavioural phenotyping; Depression; Knockout mice; Myo inositol

Indexed keywords

APOMORPHINE; CARRIER PROTEIN; INOSITOL; LITHIUM; PILOCARPINE; SODIUM MYOINOSITOL COTRANSPORTER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANXIETY; ARTICLE; BEHAVIOR GENETICS; BRAIN LEVEL; CHOLINERGIC SYSTEM; CLIMBING; CONTROLLED STUDY; DEPRESSION; DOPAMINERGIC SYSTEM; EXPERIMENTAL MODEL; FEMALE; FORCED SWIMMING TEST; FRONTAL CORTEX; HETEROZYGOSITY; HIPPOCAMPUS; HYPERACTIVITY; KNOCKOUT MOUSE; MALE; MAZE TEST; MOUSE; NERVOUS SYSTEM FUNCTION; NONHUMAN; PRIORITY JOURNAL; SEIZURE; STEREOTYPY;

ANALYSIS OF VARIANCE; ANIMALS; BEHAVIOR, ANIMAL; FEMALE; FRONTAL LOBE; HETEROZYGOTE; HIPPOCAMPUS; INOSITOL; INTRACELLULAR FLUID; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MODELS, ANIMAL; PHENOTYPE; SYMPORTERS;

ANIMALIA; MUS;

EID: 34247137244     PISSN: 16011848     EISSN: 1601183X     Source Type: Journal    
DOI: 10.1111/j.1601-183X.2006.00253.x     Document Type: Article

References (51)

1. Allison, J.H. & Stewart, M.A. (1971) Reduced brain inositol in lithium-treated rats. Nat New Biol 233, 267-8.
2. Benjamin, J., Levine, J., Fux, M., Aviv, A., Levy, D. & Belmaker, R.H. (1995) Double-blind, placebo-controlled, crossover trial of inositol treatment for panic disorder. Am J Psychiatr 152, 1084-6.
3. Berridge, M.J. (1989) The Albert Lasker Medical Awards. Inositol trisphosphate, calcium, lithium, and cell signaling. JAMA, 262, 1834-41.
4. Berry, G.T., Buccafusca, R., Greer, J.J. & Eccleston, (2004) Phosphoinositide deficiency due to inositol depletion is not a mechanism of lithium action in brain. Mol Genet Metab, 82, 87-92.
5. +/myo-inositol cotransporter leads to brain myo-inositol depletion and central apnea. J Biol Chem, 278, 18297-302.
6. Bersudsky, Y., Kaplan, Z., Shapiro, Y., Agam, G., Kofman, O. & Belmaker, R.H. (1994) Behavioral evidence for the existence of two pools of cellular inositol. Eur Neuropsychopharmacol, 4, 463-7.
7. Bradley, P.B., Engel, G., Feniuk, W., Fozard, J.R., Humphrey, P.P., Middlemiss, D.N., Mylecharane, E.J., Richardson, B.P. & Saxena, P.R. (1986) Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamine. Neuropharmacology, 25, 563-76.
8. Carter, R.J., Lione, L.A., Humby, T., Mangiarini, L., Mahal, A., Bates, G.P., Dunnett, S.B. & Morton, A.J. (1999) Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation. J Neurosci, 19, 3248-57.
9. Chauvin, T.R. & Griswold, M.D. (2004) Characterization of the expression and regulation of genes necessary for myo-inositol biosynthesis and transport in the seminiferous epithelium. Biol Reprod, 70, 744-51.
10. Cohen, H., Kotler, M., Kaplan, Z., Matar, M.A., Kofman, O. & Belmaker, R.H. (1997) Inositol has behavioral effects with adaptation after chronic administration. J Neural Transm, 104, 299-305.
11. Coupland, N.J., Ogilvie, C.J., Hegadoren, K.M., Seres, P., Hanstock, C.C. & Allen, P.S. (2005) Decreased prefrontal Myo-inositol in major depressive disorder. Biol Psychiatr, 57, 1526-34.
12. Cremona, O. & De Camilli, P. (2001) Phosphoinositides in membrane traffic at the synapse. J Cell Sci, 114, 1041-52.
13. Crusio, W.E. (2004) Flanking gene and genetic background problems in genetically manipulated mice. Biol Psychiatr, 56, 381-5.
14. De Camilli, P., Emr, S.D., McPherson, P.S. & Novick, P. (1996) Phosphoinositides as regulators in membrane traffic. Science, 271, 1533-9.
15. 2+ mobilisation in rat sympathetic neurones, but this signalling pathway does not mediate M-current inhibition. J Physiol, 520 Pt 1, 101-11.
16. Di Daniel, E., Cheng, L., Maycox, P.R. & Mudge, A.W. (2006) The common inositol-reversible effect of mood stabilizers on neurons does not involve GSK3 inhibition, myo-inositol-1-phosphate synthase or the sodium-dependent myo-inositol transporters. Mol Cell Neurosci, 32, 27-36.
17. Einat, H., Karbovski, H., Korik, J., Tsalah, D. & Belmaker, R.H. (1999) Inositol reduces depressive-like behaviors in two different animal models of depression. Psychopharmacology (Berl), 144, 158-62.
18. Fetsko, L.A., Xu, R. & Wang, Y. (2003) Alterations in D1/D2 synergism may account for enhanced stereotypy and reduced climbing in mice lacking dopamine D2L receptor. Brain Res, 967, 191-200.
19. Fux, M., Levine, J., Aviv, A. & Belmaker, R.H. (1996) Inositol treatment of obsessive-compulsive disorder. Am J Psychiatr, 153, 1219-21.
20. Gelber, D., Levine, J. & Belmaker, R.H. (2001) Effect of inositol on bulimia nervosa and binge eating. Int J Eat Disord, 29, 345-8.
21. Graham, R.M., Perez, D.M., Hwa, J. & Piascik, M.T. (1996) Alpha 1-adrenergic receptor subtypes. Molecular structure, function, and signaling. Circ Res, 78, 737-49.
22. +/myo-inositol cotransporter expressed in Xenopus oocytes. J Membr Biol, 143, 103-13.
23. Hilgemann, D.W., Feng, S. & Nasuhoglu, C. (2001) The complex and intriguing lives of PIP2 with ion channels and transporters. Sci STKE, 2001, RE19.
24. Holmes, A., Murphy, D.L. & Crawley, J.N. (2003) Abnormal behavioral phenotypes of serotonin transporter knockout mice: parallels with human anxiety and depression. Biol Psychiatr, 54, 953-9.
25. Honchar, M.P., Ackermann, K.E. & Sherman, W.R. (1989) Chronically administered lithium alters neither myo-inositol monophosphatase activity nor phosphoinositide levels in rat brain. J Neurochem, 53, 590-4.
26. Honchar, M.P., Olney, J.W. & Sherman, W.R. (1983) Systemic cholinergic agents induce seizures and brain damage in lithium-treated rats. Science, 220, 323-5.
27. Kofman, O. & Belmaker, R.H. (1993) Ziskind-Somerfeld Research Award 1993. Biochemical, behavioral, and clinical studies of the role of inositol in lithium treatment and depression. Biol Psychiatr, 34, 839-52.
28. Kofman, O., Sherman, W.R., Katz, V. & Belmaker, R.H. (1993) Restoration of brain myo-inositol levels in rats increases latency to lithium-pilocarpine seizures. Psychopharmacology (Berl), 110, 229-34.
29. Levine, J., Barak, Y., Gonzalves, M., Szor, H., Elizur, A., Kofman, O. & Belmaker, R.H. (1995) Double-blind, controlled trial of inositol treatment of depression. Am J Psychiatr, 152, 792-4.
30. Lira, A., Zhou, M., Castanon, N., Ansorge, M.S., Gordon, J.A., Francis, J.H., Bradley-Moore, M., Lira, J., Underwood, M.D., Arango, V., Kung, H.F., Hofer, M.A., Hen, R. & Gingrich, J.A. (2003) Altered depression-related behaviors and functional changes in the dorsal raphe nucleus of serotonin transporter - deficient mice. Biol Psychiatr, 54, 960-71.
31. Lubrich, B., Patishi, Y., Kofman, O., Agam, G., Berger, M., Belmaker, R.H. & Van Calker, D. (1997) Lithium-induced inositol depletion in rat brain after chronic treatment is restricted to the hypothalamus. Mol Psychiatry, 2, 407-12.
32. Martin, T.F. (2001) PI(4, 5)P(2) regulation of surface membrane traffic. Curr Opin Cell Biol, 13, 493-9.
33. Mazarati, A., Lu, X., Shinmei, S., Badie-Mahdavi, H. & Bartfai, T. (2004) Patterns of seizures, hippocampal injury and neurogenesis in three models of status epilepticus in galanin receptor type 1 (GalR1) knockout mice. Neuroscience, 128, 431-41.
34. Mejillano, M., Yamamoto, M., Rozelle, A.L., Sun, H.Q., Wang, X. & Yin, H.L. (2001) Regulation of apoptosis by phosphatidylinositol 4,5-bisphosphate inhibition of caspases, and caspase inactivation of phosphatidylinositol phosphate 5-kinases. J Biol Chem, 276, 1865-72.
35. Miyakawa, T., Leiter, L.M., Gerber, D.J., Gainetdinov, R.R., Sotnikova, T.D., Zeng, H., Caron, M.G. & Tonegawa, S. (2003) Conditional calcineurin knockout mice exhibit multiple abnormal behaviors related to schizophrenia. Proc Natl Acad Sci U S A, 100, 8987-92.
36. Moore, G.J., Bebchuk, J.M., Parrish, J.K., Faulk, M.W., Arfken, C.L., Strahl-Bevacqua, J. & Manji, H.K. (1999) Temporal dissociation between lithium-induced changes in frontal lobe myoinositol and clinical response in manic-depressive illness. Am J Psychiatr, 156, 1902-8.
37. O'Brien, W.T., Harper, A.D., Jove, F., Woodgett, J.R., Maretto, S., Piccolo, S. & Klein, P.S. (2004) Glycogen synthase kinase-3-beta haploinsufficiency mimics the behavioral and molecular effects of lithium. J Neurosci, 24, 6791-8.
38. Parthasarathy, R. & Eisenberg, F., J.R. (1986) The inositol phospholipids: a stereochemical view of biological activity. Biochem J, 235, 313-22.
39. Patel, S., Meldrum, B.S. & Fine, A. (1988) Susceptibility to pilocarpine-induced seizures in rats increases with age. Behav Brain Res, 31, 165-7.
40. Porsolt, R.D., Bertin, A. & Jalfre, M. (1977) Behavioral despair in mice: a primary screening test for antidepressants. Arch Int Pharmacodyn Ther, 229, 327-36.
41. Rouser, G., Kritchevsky, G., Yamanoto, A. & Baxter, C.F. (1972) Lipids in the nervous system of different species as a function of age: brain, spinal cord, peripheral nerve, purified whole cell preparations, and subcellular particulates: regulatory mechanisms and membrane structure. Adv Lipid Res, 10, 261-360.
42. Sechi, A.S. & Wehland, J. (2000) The actin cytoskeleton and plasma membrane connection: PtdIns(4,5)P(2) influences cytoskeletal protein activity at the plasma membrane. J Cell Sci, 113 Pt 21, 3685-95.
43. Shaldubina, A., Johanson, R.A., O'Brien, T.W., Buccafusca, R., Agam, G., Belmaker, R., Klein, P.S., Bersudsky, Y. & Berry, G.T. SMIT1 haploinsufficiency causes brain inositol deficiency without affecting lithium-sensitive behavior. Mol Genet Metab, 2006.
44. Shamir, A., Shaltiel, G., Greenberg, M.L., Belmaker, R.H. & Agam, G. (2003) The effect of lithium on expression of genes for inositol biosynthetic enzymes in mouse hippocampus; a comparison with the yeast model. Brain Res Mol Brain Res, 115, 104-10.
45. Shapiro, J., Belmaker, R.H., Biegon, A., Seker, A. & Agam, G. (2000) Scyllo-inositol in post-mortem brain of bipolar, unipolar and schizophrenic patients. J Neural Transm, 107, 603-7.
46. Takenawa, T. & Itoh, T. (2001) Phosphoinositides, key molecules for regulation of actin cytoskeletal organization and membrane traffic from the plasma membrane. Biochim Biophys Acta, 1533, 190-206.
47. Thakker, D.R., Natt, F., Husken, D., Van Der Putten, H., Maier, R., Hoyer, D. & Cryan, J.F. (2005) siRNA-mediated knockdown of the serotonin transporter in the adult mouse brain. Mol Psychiatr, 10, 782-9, 714.
48. Undie, A.S., Weinstock, J., Sarau, H.M. & Friedman, E. (1994) Evidence for a distinct D1-like dopamine receptor that couples to activation of phosphoinositide metabolism in brain. J Neurochem, 62, 2045-8.
49. 2+ concentration decrease in GH4C1 cells. J Biol Chem, 265, 10320-6.
50. Van Calker, D. & Belmaker, R.H. (2000) The high affinity inositol transport system - implications for the pathophysiology and treatment of bipolar disorder. Bipolar Disord, 2, 102-7.
51. +-glucose cotransporters: SLC5. Physiology (Bethesda), 19, 370-6.