Aging is associated with an increased susceptibility to ischaemic necrosis due to microvascular perfusion failure but not a reduction in ischaemic tolerance

Clinical Science

Volumn 112, Issue 7-8, 2007, Pages 429-440

  Harder, Yves ^a,b   Amon, Michaela ^a   Georgi, Mirko ^a   Scheuer, Claudia ^a   Schramm, Rene ^a   Rücker, Martin ^a   Pittet, Brigitte ^b   Erni, Dominique ^c   Menger, Michael D ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^c UNIVERSITY OF BERN   (Switzerland)

Author keywords

Aging; Haem oxygenase 1 (HO 1); Heat shock protein 32 (HSP 32); Ischaemic tolerance; Microcirculation; Necrosis; Pedicled skin flap

Indexed keywords

HEME OXYGENASE 1;

AGING; ANIMAL EXPERIMENT; ARTICLE; CAPILLARY DENSITY; CAPILLARY FLOW; CONTROLLED STUDY; DISEASE PREDISPOSITION; FEMALE; GRAFT NECROSIS; IMMUNOHISTOCHEMISTRY; MALE; MICROVASCULAR ISCHEMIA; MICROVASCULARIZATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN FLAP; TISSUE NECROSIS; WESTERN BLOTTING;

AGING; ANIMALS; BLOTTING, WESTERN; CAPILLARIES; EAR, EXTERNAL; FEMALE; GRAFT SURVIVAL; HEME OXYGENASE (DECYCLIZING); IMMUNOHISTOCHEMISTRY; ISCHEMIA; MALE; MICE; MICE, INBRED HRS; MICROSCOPY, FLUORESCENCE; MODELS, ANIMAL; NECROSIS; REGIONAL BLOOD FLOW; SKIN; SURGICAL FLAPS;

EID: 34247132260     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20060187     Document Type: Article

References (42)

1. El-Khatib, H. A. and Bener, A. (2004) Abdominal dermolipectomy in an abdomen with pre-existing scars: a different concept. Plast. Reconstr. Surg. 114, 992-997
2. Erni, D. and Harder, Y. (2003) The dissection of the rectus abdominis myocutaneous flap with complete preservation of the anterior rectus sheath. Br. J. Plast. Surg. 56, 395-400
3. Ng, R. L., Youssef, A., Kronowitz, S. J., Lipa, J. E., Potochny, J. and Reece, G. P. (2004) Technical variations of the bipedicled TRAM flap in unilateral breast reconstruction: effects of conventional versus microsurgical techniques of pedicle transfer on complications rates. Plast. Reconstr. Surg. 114, 374-384
4. Moran, S. L., Nava, G., Behnam, A. B. and Serletti, J. M. (2003) An outcome analysis comparing the thoracodorsal and internal mammary vessels as recipient sites for microvascular breast reconstruction: a prospective study of 100 patients. Plast. Reconstr. Surg. 111, 1876-1882
5. Redett, R. J., Robertson, B. C., Chang, B., Girotto, J. and Vaughan, T. (2000) Limb salvage of lower-extremity wounds using free gracilis muscle reconstruction. Plast. Reconstr. Surg. 106, 1507-1513
6. Zuker, R. M., Manktelow, R. T., Palmer, J. A. and Rosen, I. B. (1980) Head and neck reconstruction following resection of carcinoma, using microvascular free flaps. Surgery 88, 461-466
7. Vemuri, C., Wainess, R. M., Dimick, J. B. et al. (2004) Effect of increasing patient age on complication rates following intact abdominal aortic aneurysm repair in the United States. J. Surg. Res. 118, 26-31
8. Dimick, J. B., Chen, S. L., Taheri, P. A., Henderson, W. G., Khuri, S. F. and Campbell, D. A. (2004) Hospital costs associated with surgical complications: a report from the private-sector National Surgical Quality Improvement Program. J. Am. Coll. Surg. 199, 531-537
9. Haraguchi, S., Koizumi, K., Hatori, N. et al. (2001) Prediction of the postoperative pulmonary function and complication rate in elderly patients. Surg. Today 31, 860-865
10. Hirose, H., Amano, A., Yoshida, S., Takahashi, A., Nagano, N. and Kohmoto, T. (2000) Coronary artery bypass grafting in the elderly. Chest 117, 1262-1270
11. Lightner, A. M., Glasgow, R. E., Jordan, T. H. et al. (2004) Pancreatic resection in the elderly. J. Am. Coll. Surg. 198, 697-706
12. Davis, W. J., Vaynblat, M., Chiavarelli, M. et al. (2004) Open heart surgery in patients 85 years and older. J. Card. Surg. 19, 7-11
13. Maulik, N., Engelman, D. T., Watanabe, M. et al. (1996) Nitric oxide/carbon monoxide. A molecular switch for myocardial preservation during ischemia. Circulation 94, II398-II406
14. Shimizu, H., Takahashi, T., Suzuki, T. et al. (2000) Protective effect of heme oxygenase induction in ischemic acute renal failure. Crit. Care Med. 28, 809-817
15. Rücker, M., Schäfer, T., Roesken, F., Spitzer, W. J., Bauer, M. and Menger, M. D. (2001) Local heat-shock priming-induced improvement in microvascular perfusion in osteomyocutaneous flaps is mediated by heat-shock protein 32. Br. J. Surg. 88, 450-457
16. Barker, J. H., Hammersen, F., Bondar, I. et al. (1989) Direct monitoring of nutritive blood flow in a failing skin flap: the hairless mouse ear skin-flap model. Plast. Reconstr. Surg. 84, 303-313
17. Hedrich, H., Bullock, G. and Petrusz, P. (2005) The Handbook of Experimental Animals, the Laboratory Mouse, Elsevier Academic Press, London
18. Vollmar, B., Morgenthaler, M., Amon, M. and Menger, M. D. (2000) Skin microvascular adaptations during maturation and aging of hairless mice. Am. J. Physiol. Heart Circ. Physiol. 279, H1591-H1599
19. Menger, M. D., Pelikan, S., Steiner, D. and Messmer, K. (1992) Microvascular ischemia-reperfusion injury in striated muscle: significance of 'reflow paradox'. Am. J. Physiol. 263, H1901-H1906.
20. Klyscz, T., Junger, M., Jung, F. and Zeintl, H. (1997) Cap image: a new kind of computer-assisted video image analysis system for dynamic capillary microscopy. Biomed. Tech. 42, 168-175
21. Menger, M. D., Barker, J. H. and Messmer, K. (1992) Capillary blood perfusion during postischemic reperfusion in striated muscle. Plast. Reconstr. Surg. 89, 1104-1114
22. Amon, M., Menger, M. D. and Vollmar, B. (2003) Heme oxygenase and nitric oxide synthase mediate cooling-associated protection against TNF-α-induced microcirculatory dysfunction and apoptotic cell death. FASEB J. 17, 175-185
23. Rücker, M., Schäfer, T., Scheuer, C., Harder, Y., Vollmar, B. and Menger, M. D. (2006) Local heat shock priming promotes recanalization of thromboembolized microvasculature by upregulation of plasminogen activators. Arterioscler. Thromb. Vasc. Biol. 26, 1632-1639
24. Rigberg, D., Cole, M., Hiyama, D. and McFadden, D. (2000) Surgery in the nineties. Am. Surg. 66, 813-816
25. Beausang, E. S., Ang, E. E., Lipa, J. E. et al. (2003) Microvascular free tissue transfer in elderly patients: the Toronto experience. Head Neck 25, 549-553
26. Borggreven, P. A., Kuik, D. J., Quak, J. J., de Bree, R., Snow, G. B. and Leemans, C. R. (2003) Comorbid condition as a prognostic factor for complications in major surgery of the oral cavity and oropharynx with microvascular soft tissue reconstruction. Head Neck 25, 808-815
27. Mariani, J., Ou, R., Bailey, M. et al. (2000) Tolerance to ischemia and hypoxia is reduced in aged human myocardium. J. Thorac. Cardiovasc. Surg. 120, 660-667
28. Loubani, M., Ghosh, S. and Galinanes, M. (2003) The aging human myocardium: tolerance to ischemia and responsiveness to ischemic preconditioning. J. Thorac. Cardiovasc. Surg. 126, 143-147
29. Evans, E., Rendell, M., Bartek, J. et al. (1993) Thermally-induced cutaneous vasodilatation in aging. J. Gerontol. 48, M53-M57
30. Schubert, V. and Fagrell, B. (1991) Evaluation of the dynamic cutaneous post-ischaemic hyperaemia and thermal response in elderly subjects and in an area at risk for pressure sores. Clin. Physiol. 11, 169-182
31. Ishida, S., Hamasaki, S., Kamekou, M. et al. (1996) Advancing age is associated with diminished vascular remodeling and impaired vasodilation in resistance coronary arteries. Coronary Artery Dis. 14, 443-449
32. Hirschi, K. K. and D'Amore, P. A. (1996) Pericytes in the microvasculature. Cardiovasc. Res. 32, 687-698
33. Skalli, O., Pelte, M. F., Peclet, M. C. et al. (1989) Alpha-smooth muscle actin, a differentiation marker of smooth muscle cells, is present in microfilamentous bundles of pericytes. J. Histochem. Cytochem. 37, 315-321
34. Haefliger, I. O., Zschauer, A. and Anderson, D. R. (1994) Relaxation of retinal pericyte contractile tone through the nitric oxide-cyclic guanosine monophosphate pathway. Invest. Ophthalmol. Vis. Sci. 35, 991-997
35. Suematsu, M., Wakabayashi, Y. and Ishimura, Y. (1996) Gaseous monoxides: a new class of microvascular regulator in the liver. Cardiovasc. Res. 32, 679-686
36. Suematsu, M., Goda, N., Sano, T. et al. (1995) Carbon monoxide: an endogenous modulator of sinusoidal tone in the perfused rat liver. J. Clin. Invest. 96, 2431-2437
37. Choi, A. M., Sylvester, S., Otterbein, L. and Holbrook, N. J. (1995) Molecular responses to hyperoxia in vivo: relationship to increased tolerance in aged rats. Am. J. Respir. Cell. Mol. Biol. 13, 74-82
38. Miyamura, N., Ogawa, T., Boylan, S., Morse, L. S., Handa, J. T. and Hjelmeland, L. M. (2004) Topographic and age-dependent expression of heme oxygenase-1 and catalase in the human retinal pigment epithelium. Invest. Ophthalmol. Vis. Sci. 45, 1562-1565
39. Kozma, F., Johnson, R. A., Zhang, F., Yu, C., Tong, X. and Nasjletti, A. (1999) Contribution of endogenous carbon monoxide to regulation of diameter in resistance vessels. Am. J. Physiol. 276, R1087-R1094
40. Kubulus, D., Roesken, F., Amon, M. et al. (2004) Mechanism of the delay phenomenon: tissue protection is mediated by heme oxygenase-1. Am. J. Physiol. Heart Circ. Physiol. 287, H2332-H2340
41. Vollmar, B., Pradarutti, S., Nickels, R. M. and Menger, M. D. (2002) Age-associated loss of immunomodulatory protection by granulocyte-colony stimulating factor in endotoxic rats. Shock 18, 348-354
42. Menger, M. D., Barker, J. H. and Messmer, K. (1992) Capillary blood perfusion during postischemic reperfusion in striated muscle Plast. Reconstr. Surg. 89, 1104-1114