Evidence of hypercoagulability and inflammation in young patients long after acute cerebral ischaemia

Thrombosis Research

Volumn 120, Issue 1, 2007, Pages 39-46

  Anžej, Saša ^a   Božič, Mojca ^a   Antovič, Aleksandra ^a   Peternel, Polona ^a   Gašperšič, Nataša ^a   Rot, Uroš ^a   Tratar, Gregor ^a   Stegnar, Mojca ^a  

^a UNIVERSITY MEDICAL CENTRE LJUBLJANA   (Slovenia)

Author keywords

Acute cerebral ischaemia; Global haemostasis tests; Hypercoagulability; Soluble P selectin; Thrombophilia

Indexed keywords

ACETYLSALICYLIC ACID; ANTICOAGULANT AGENT; ANTILIPEMIC AGENT; ANTITHROMBOCYTIC AGENT; C REACTIVE PROTEIN; CLOPIDOGREL; D DIMER; FIBRINOGEN; LUPUS ANTICOAGULANT; PADGEM PROTEIN; TICLOPIDINE; WARFARIN;

ADULT; ARTICLE; BLOOD CLOTTING; BLOOD SAMPLING; BRAIN ISCHEMIA; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FIBRINOLYSIS; HEMOSTASIS; HUMAN; HYPERCOAGULABILITY; INFLAMMATION; MALE; PATIENT REFERRAL; PRIORITY JOURNAL; RECURRENT DISEASE; RISK FACTOR; THROMBOPHILIA;

ACUTE DISEASE; ADULT; BLOOD COAGULATION DISORDERS; BLOOD COAGULATION TESTS; BRAIN ISCHEMIA; CASE-CONTROL STUDIES; CEREBROVASCULAR ACCIDENT; FEMALE; HEMOSTASIS; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; ISCHEMIC ATTACK, TRANSIENT; MALE; MIDDLE AGED; TIME FACTORS;

EID: 34247111411     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.thromres.2006.08.005     Document Type: Article

References (40)

1. Tegos T.J., Kalodiki E., Daskalopoulou S.S., and Nicolaides A.N. Stroke: epidemiology, clinical picture, and risk factors: Part I of III. Angiology 51 (2000) 793-808
2. Koudstaal P.J. Transient ischemic attacks: diagnosis and prognosis. Cerebrovasc Dis 4 (1994) 40-46
3. Hankey G.J. Stroke: how large a public health problem, and how can the neurologist help?. Arch Neurol 56 (1999) 748-754
4. Adams Jr. H.P., Kappelle L.J., Biller J., Gordon D.L., Love B.B., Gomez F., et al. Ischemic stroke in young adults. Experience in 329 patients enrolled in the Iowa Registry of stroke in young adults. Arch Neurol 52 (1995) 491-495
5. Munts A.G., van Genderen P.J., Dippel D.W., van Kooten F., and Koudstaal P.J. Coagulation disorders in young adults with acute cerebral ischaemia. J Neurol 245 (1998) 21-25
6. Carolei A., Marini C., Ferranti E., Frontoni M., Prencipe M., and Fieschi C. A prospective study of cerebral ischemia in the young. Analysis of pathogenic determinants. The National Research Council Study Group. Stroke 24 (1993) 362-367
7. Kittner S.J., Stern B.J., Wozniak M., Buchholz D.W., Earley C.J., Feeser B.R., et al. Cerebral infarction in young adults: the Baltimore-Washington Cooperative Young Stroke Study. Neurology 50 (1998) 890-894
8. Lanzino G., Andreoli A., Di Pasquale G., Urbinati S., Limoni P., Serracchioli A., et al. Etiopathogenesis and prognosis of cerebral ischemia in young adults. A survey of 155 treated patients. Acta Neurol Scand 84 (1991) 321-325
9. Lindsberg P.J., and Grau A.J. Inflammation and infections as risk factors for ischemic stroke. Stroke 34 (2003) 2518-2532
10. Goldstein L.B., Adams R., Becker K., Furberg C.D., Gorelick P.B., Hademenos G., et al. Primary prevention of ischemic stroke: a statement for healthcare professionals from the Stroke Council of the American Heart Association. Stroke 32 (2001) 280-299
11. Lip G.Y., Blann A.D., Farooqi I.S., Zarifis J., Sagar G., and Beevers D.G. Sequential alterations in haemorheology, endothelial dysfunction, platelet activation and thrombogenesis in relation to prognosis following acute stroke: The West Birmingham Stroke Project. Blood Coagul Fibrinolysis 13 (2002) 339-347
12. Barber M., Langhorne P., Rumley A., Lowe G.D., and Stott D.J. Hemostatic function and progressing ischemic stroke: D-dimer predicts early clinical progression. Stroke 35 (2004) 1421-1425
13. Winbeck K., Poppert H., Etgen T., Conrad B., and Sander D. Prognostic relevance of early serial C-reactive protein measurements after first ischemic stroke. Stroke 33 (2002) 2459-2464
14. Antovic J.P., Yngen M., Ostenson C.G., Antovic A., Wallen H.N., Jorneskog G., et al. Thrombin activatable fibrinolysis inhibitor and hemostatic changes in patients with type I diabetes mellitus with and without microvascular complications. Blood Coagul Fibrinolysis 14 (2003) 551-556
15. Antovic A., Blomback M., Bremme K., Van Rooijen M., and He S. Increased hemostasis potential persists in women with previous thromboembolism with or without APC resistance. J Thromb Haemost 1 (2003) 2531-2535
16. He S., Antovic A., and Blomback M. A simple and rapid laboratory method for determination of haemostasis potential in plasma: II. Modifications for use in routine laboratories and research work. Thromb Res 103 (2001) 355-361
17. Bozic M., Stegnar M., Fermo I., Ritonja A., Peternel P., Stare J., et al. Mild hyperhomocysteinemia and fibrinolytic factors in patients with history of venous thromboembolism. Thromb Res 100 (2000) 271-278
18. Kristensen B., Malm J., Nilsson T.K., Hultdin J., Carlberg B., and Olsson T. Increased fibrinogen levels and acquired hypofibrinolysis in young adults with ischemic stroke. Stroke 29 (1998) 2261-2267
19. Haapaniemi E., Soinne L., Syrjala M., Kaste M., and Tatlisumak T. Serial changes in fibrinolysis and coagulation activation markers in acute and convalescent phase of ischemic stroke. Acta Neurol Scand 110 (2004) 242-247
20. Di Napoli M., and Papa F. Inflammation, hemostatic markers, and antithrombotic agents in relation to long-term risk of new cardiovascular events in first-ever ischemic stroke patients. Stroke 33 (2002) 1763-1771
21. Fon E.A., Mackey A., Cote R., Wolfson C., McIlraith D.M., Leclerc J., et al. Hemostatic markers in acute transient ischemic attacks. Stroke 25 (1994) 282-286
22. Ince B., Bayram C., Harmanci H., and Ulutin T. Hemostatic markers in ischemic stroke of undetermined etiology. Thromb Res 96 (1999) 169-174
23. Reganon E., Vila V., Martinez-Sales V., Vaya A., Lago A., Alonso P., et al. Association between inflammation and hemostatic markers in atherothrombotic stroke. Thromb Res 112 (2003) 217-221
24. Nadar S.K., Lip G.Y., and Blann A.D. Platelet morphology, soluble P selectin and platelet P-selectin in acute ischaemic stroke. The West Birmingham Stroke Project. Thromb Haemost 92 (2004) 1342-1348
25. Yip H.K., Chen S.S., Liu J.S., Chang H.W., Kao Y.F., Lan M.Y., et al. Serial changes in platelet activation in patients after ischemic stroke: role of pharmacodynamic modulation. Stroke 35 (2004) 1683-1687
26. Bushnell C.D., and Goldstein L.B. Diagnostic testing for coagulopathies in patients with ischemic stroke. Stroke 31 (2000) 3067-3078
27. Haberl R.L. Infrequency of stroke caused by specific coagulation disorders. Cerebrovasc Dis 5 (1995) 391-396
28. Hankey G.J., Eikelboom J.W., van Bockxmeer F.M., Lofthouse E., Staples N., and Baker R.I. Inherited thrombophilia in ischemic stroke and its pathogenic subtypes. Stroke 32 (2001) 1793-1799
29. Ferro D., Quintarelli C., Rasura M., Antonini G., and Violi F. Lupus anticoagulant and the fibrinolytic system in young patients with stroke. Stroke 24 (1993) 368-370
30. Levine J.S., Branch D.W., and Rauch J. The antiphospholipid syndrome. N Engl J Med 346 (2002) 752-763
31. Qizilbash N. Fibrinogen and cerebrovascular disease. Eur Heart J 16 (1995) 42-45
32. Folsom A.R., Rosamond W.D., Shahar E., Cooper L.S., Aleksic N., Nieto F.J., et al. Prospective study of markers of hemostatic function with risk of ischemic stroke. The Atherosclerosis Risk in Communities (ARIC) Study Investigators. Circulation 100 (1999) 736-742
33. Kofoed S.C., Wittrup H.H., Sillesen H., and Nordestgaard B.G. Fibrinogen predicts ischaemic stroke and advanced atherosclerosis but not echolucent, rupture-prone carotid plaques: the Copenhagen City Heart Study. Eur Heart J 24 (2003) 567-576
34. Iyigun I., and Bakirci Y. Plasma concentrations of C-reactive protein and fibrinogen in ischaemic stroke. J Int Med Res 30 (2002) 591-596
35. Beamer N.B., Coull B.M., Clark W.M., Briley D.P., Wynn M., and Sexton G. Persistent inflammatory response in stroke survivors. Neurology 50 (1998) 1722-1728
36. Resch K.L., Ernst E., Matrai A., and Paulsen H.F. Fibrinogen and viscosity as risk factors for subsequent cardiovascular events in stroke survivors. Ann Intern Med 117 (1992) 371-375
37. Ross R. Atherosclerosis - an inflammatory disease. N Engl J Med 340 (1999) 115-126
38. Bowman T.S., Sesso H.D., Ma J., Kurth T., Kase C.S., Stampfer M.J., et al. Cholesterol and the risk of ischemic stroke. Stroke 34 (2003) 2930-2934
39. Shahar E., Chambless L.E., Rosamond W.D., Boland L.L., Ballantyne C.M., McGovern P.G., et al. Plasma lipid profile and incident ischemic stroke: the Atherosclerosis Risk in Communities (ARIC) study. Stroke 34 (2003) 623-631
40. Suk S.H., Sacco R.L., Boden-Albala B., Cheun J.F., Pittman J.G., Elkind M.S., et al. Abdominal obesity and risk of ischemic stroke: the Northern Manhattan Stroke Study. Stroke 34 (2003) 1586-1592