Physiological consequences of small RNA-mediated regulation of glucose-phosphate stress

Current Opinion in Microbiology

Volumn 10, Issue 2, 2007, Pages 146-151

  Vanderpool, Carin K ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL RNA; CHAPERONE; ENDONUCLEASE; ENOLASE; GLUCOSE PHOSPHATE; GLUCOSE TRANSPORTER; GLYCOLYTIC ENZYME; HOST FACTOR 1; MESSENGER RNA; REGULATOR PROTEIN; RIBONUCLEASE E; SMALL RNA; SUGAR PHOSPHATE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SGRR; UNCLASSIFIED DRUG;

BASE PAIRING; ESCHERICHIA COLI; GENE EXPRESSION; NONHUMAN; OXIDATIVE STRESS; PROTEIN STABILITY; PROTEIN SYNTHESIS INHIBITION; REGULATORY MECHANISM; REVIEW; RNA DEGRADATION; STRESS; TRANSCRIPTION REGULATION; TRANSLATION REGULATION;

BASE SEQUENCE; ESCHERICHIA COLI; GENE EXPRESSION REGULATION, BACTERIAL; GLUCOSEPHOSPHATES; MOLECULAR SEQUENCE DATA; RNA, BACTERIAL; RNA, UNTRANSLATED;

ESCHERICHIA COLI;

EID: 34247104624     PISSN: 13695274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mib.2007.03.011     Document Type: Review

References (20)

1. Aiba H. Mechanism of RNA silencing by Hfq-binding small RNAs. Curr Opin Microbiol 10 (2007) 134-139
2. Englesberg E., Anderson R.L., Weinberg R., Lee N., Hoffee P., Huttenhauer G., and Boyer H. l-arabinose-sensitive, l-ribulose 5-phosphate 4-epimerase-deficient mutants of Escherichia coli. J Bacteriol 84 (1962) 137-146
3. Irani M.H., and Maitra P.K. Properties of Escherichia coli mutants deficient in enzymes of glycolysis. J Bacteriol 132 (1977) 398-410
4. Kadner R.J., Murphy G.P., and Stephens C.M. Two mechanisms for growth inhibition by elevated transport of sugar phosphates in Escherichia coli. J Gen Microbiol 138 (1992) 2007-2014
5. Lee A.T., and Cerami A. Elevated glucose 6-phosphate levels are associated with plasmid mutations in vivo. Proc Natl Acad Sci USA 84 (1987) 8311-8314
6. Yarmolinsky M.B., Wiesmeyer H., Kalckar H.M., and Jordon E. Hereditary defects in galactose metabolism in Escherichia coli mutants. II. Galactose-induced sensitivity. Proc Natl Acad Sci USA 45 (1959) 1786-1791
7. Vanderpool C.K., and Gottesman S. Involvement of a novel transcriptional activator and small RNA in post-transcriptional regulation of the glucose phosphoenolpyruvate phosphotransferase system. Mol Microbiol 54 (2004) 1076-1089
8. Kimata K., Tanaka Y., Inada T., and Aiba H. Expression of the glucose transporter gene, ptsG, is regulated at the mRNA degradation step in response to glycolytic flux in Escherichia coli. EMBO J 20 (2001) 3587-3595
9. Zhang A., Wassarman K.M., Rosenow C., Tjaden B.C., Storz G., and Gottesman S. Global analysis of small RNA and mRNA targets of Hfq. Mol Microbiol 50 (2003) 1111-1124
10. Morita T., Mochizuki Y., and Aiba H. Translational repression is sufficient for gene silencing by bacterial small noncoding RNAs in the absence of mRNA destruction. Proc Natl Acad Sci USA 103 (2006) 4858-4863. This study showed that translational repression and mRNA degradation can be uncoupled for at least two sRNA-mRNA pairs. These results imply that, at least in these cases, translational repression can be the primary regulatory step for negative regulation by sRNAs.
11. Kawamoto H., Koide Y., Morita T., and Aiba H. Base-pairing requirement for RNA silencing by a bacterial small RNA and acceleration of duplex formation by Hfq. Mol Microbiol 61 (2006) 1013-1022. This is one of few studies where base-pairing determinants were carefully dissected. The authors showed genetically and biochemically that complementarity between SgrS and ptsG mRNA is required for physical interactions between the two RNAs and for regulation of ptsG.
12. Kawamoto H., Morita T., Shimizu A., Inada T., and Aiba H. Implication of membrane localization of target mRNA in the action of a small RNA: mechanism of post-transcriptional regulation of glucose transporter in Escherichia coli. Genes Dev 19 (2005) 328-338. This study provides evidence that base pairing between SgrS and ptsG mRNA is not sufficient for regulation in vivo. A novel regulatory mechanism involving cotranslational membrane association of the ptsG mRNA is apparently needed to enable SgrS to function.
13. Morita T., Maki K., and Aiba H. RNase E-based ribonucleoprotein complexes: mechanical basis of mRNA destabilization mediated by bacterial noncoding RNAs. Genes Dev 19 (2005) 2176-2186
14. Morita T., Kawamoto H., Mizota T., Inada T., and Aiba H. Enolase in the RNA degradosome plays a crucial role in the rapid decay of glucose transporter mRNA in the response to phosphosugar stress in Escherichia coli. Mol Microbiol 54 (2004) 1063-1075
15. Polayes D.A., Rice P.W., Garner M.M., and Dahlberg J.E. Cyclic AMP-cyclic AMP receptor protein as a repressor of transcription of the spf gene of Escherichia coli. J Bacteriol 170 (1988) 3110-3114
16. Wassarman K.M., Repoila F., Rosenow C., Storz G., and Gottesman S. Identification of novel small RNAs using comparative genomics and microarrays. Genes Dev 15 (2001) 1637-1651
17. Vanderpool CK, Gottesman S: The novel transcription factor SgrR coordinates the response to glucose-phosphate stress. J Bact 2007, in press.
18. Møller T., Franch T., Udesen C., Gerdes K., and Valentin-Hansen P. Spot 42 RNA mediates discoordinate expression of the E. coli galactose operon. Genes Dev 16 (2002) 1696-1706
19. Morita T., El-Kazzaz W., Tanaka Y., Inada T., and Aiba H. Accumulation of glucose 6-phosphate or fructose 6-phosphate is responsible for destabilization of glucose transporter mRNA in Escherichia coli. J Biol Chem 278 (2003) 15608-15614
20. Antal M., Bordeau V., Douchin V., and Felden B. A small bacterial RNA regulates a putative ABC transporter. J Biol Chem 280 (2005) 7901-7908