Contraction-relaxation coupling mechanism characterization in the thermodynamic phase plane: Normal vs. impaired left ventricular ejection fraction

Journal of Applied Physiology

Volumn 102, Issue 4, 2007, Pages 1367-1373

  Wu, Yue ^a   Yu, Yingbo ^b   Kovács, Sándor J ^a,b,c  

^a WASHINGTON UNIVERSITY   (United States)

^b WASHINGTON UNIVERSITY IN ST LOUIS   (United States)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cardiac power; Left ventricular function; Mathematical modeling

Indexed keywords

ADULT; AGED; ARTICLE; CONTROLLED STUDY; HEART CATHETERIZATION; HEART CYCLE; HEART LEFT VENTRICLE EJECTION FRACTION; HUMAN; KINETICS; MATHEMATICAL MODEL; NORMAL HUMAN; PRIORITY JOURNAL; THERMODYNAMICS;

ANIMALS; COMPUTER SIMULATION; DIAGNOSIS, COMPUTER-ASSISTED; HEART VENTRICLES; HUMANS; MODELS, CARDIOVASCULAR; MYOCARDIAL CONTRACTION; STROKE VOLUME; THERMODYNAMICS; VENTRICULAR DYSFUNCTION, LEFT;

EID: 34147165698     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00593.2006     Document Type: Article

References (21)

1. Aurigemma GP. Diastolic heart failure - a common and lethal condition by any name. N Engl J Med 355: 308-310, 2006.
2. Bers DM. Cardiac excitation-contraction coupling. Nature 415: 198-205, 2002.
3. Burlew BS, Weber KT. Connective tissue and the heart: functional significance and regulatory mechanisms. Cardiol Clin 18: 435-442, 2002.
4. Cazorla O, Freiburg A, Helmes T, McNabb M, Wu Y, Trombitás K, Labeit S, Granzier H. Differential expression of cardiac titin isoforms and modulation of cellular stiffness. Circ Res 86: 59-67, 2000.
5. Eucker SA, Lisauskas JB, Courtois MR, Kovács SJ. Analysis of left ventricular hemodynamics in physiological hyperspace. J Appl Physiol 92: 323-330, 2002.
6. Eucker SA, Lisauskas JB, Singh J, Kovács SJ. Phase-plane analysis of left ventricular hemodynamics. J Appl Physiol 90: 2238-2244, 2001.
7. European Study Group on Diastolic Heart Failure. How to diagnose diastolic heart failure. Eur Heart J 19: 990-1003, 1998.
8. Gao WD, Perez NG, Marban E. Calcium cycling and contractile activation in intact mouse cardiac muscle. J Physiol 507: 175-184, 1998.
9. Karamanoglu M, Kovács SJ. Thermodynamic phase-plane analysis of ventricular contraction and relaxation [Online]. http://www.biomedicalengineering-online.com/content/pdf/1475-925X-3-6.pdf.
10. Katz AM, Lorell BH. Regulation of cardiac contraction and relaxation. Circulation 102 Suppl 4: IV69-IV74, 2000.
11. Lisauskas JB, Singh J, Bowman AW, Kovács SJ. Chamber properties from transmitral flow: prediction of average and passive left ventricular diastolic stiffness. J Appl Physiol 91: 154-162, 2001.
12. MacKinnon R, Gwathmey JK, Allen PD, Briggs GM, Morgan JP. Modulation by the thyroid state of intracellular calcium and contractility in ferret ventricular muscle. Circ Res 63: 1080-1089, 1988.
13. Nikolic S, Yellin EL, Tamura K, Vetter H, Tamura T, Meisner JS, Frater RW. Passive properties of canine left ventricle: diastolic stiffness and restoring forces. Circ Res 62: 1210-1222, 1988.
14. Peng GC, Zee DS, Minor LB. Phase-plane analysis of gaze stabilization to high-acceleration head thrusts: a continuum across normal subjects and patients with loss of vestibular function. J Neurophysiol 91: 1763-1781, 2003.
15. Rosen BD, Gerber BL, Edvardsen T, Castillo E, Amado LC, Nasir K, Kraitchman DL, Osman NF, Bluemke DA, Lima JA. Late systolic onset of regional LV relaxation demonstrated in three-dimensional space by MRI tissue tagging. Am J Physiol Heart Circ Physiol 287: H1740-H1746, 2004.
16. Sagawa K, Maughan L, Suga H, Sunagawa K. Cardiac Contraction and the Pressure-Volume Relationship. New York: Oxford University Press, 1988.
17. Solomon SB, Nikolic SD, Frater RW, Yellin EL. Contraction- relaxation coupling: determination of the onset of diastole. Am J Physiol Heart Circ Physiol 277: H23-H27, 1999.
18. Suga H. Total mechanical energy of a ventricle model and cardiac oxygen consumption. Am J Physiol Heart Circ Physiol 236: H498-H505, 1979.
19. Wu Y, Bowman AW, Kovács SJ. Frequency-based analysis of diastolic function: the early rapid filling phase generates negative intraventricular wave reflections. Cardiovasc Eng 5: 1-12, 2005.
20. Wu Y, Kovács SJ. Frequency-based analysis of the early, rapid-filling pressure-flow relation elucidates diastolic efficiency mechanisms. Am J Physiol Heart Circ Physiol 291: H2942-H2949, 2006.
21. Zile MR, Brutsaert DL. New concepts in diastolic dysfunction and diastolic heart failure. I. Diagnosis, prognosis, and measurements of diastolic function. Circulation 105: 1387-1393, 2002.