13C enrichment of carbons 2 and 8 of purine by folate-dependent reactions after [13C]formate and [2-13C]glycine dosing in adult humans

Metabolism: Clinical and Experimental

Volumn 56, Issue 5, 2007, Pages 708-715

  Baggott, Joseph E ^a   Gorman, Gregory S ^b   Tamura, Tsunenobu ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b SOUTHERN RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 GLYCINE C 13; CARBON; CARBON 13; CARBON 2; CARBON 8; FOLIC ACID; ISOTOPE; PURINE; SODIUM FORMATE C 13; UNCLASSIFIED DRUG; URIC ACID; DIAGNOSTIC AGENT; FORMIC ACID DERIVATIVE; GLYCINE; PURINE DERIVATIVE;

ARTICLE; CHEMICAL REACTION; CIRCADIAN RHYTHM; CONTROLLED STUDY; DRUG METABOLISM; HUMAN; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; URINALYSIS; ADULT; BIOSYNTHESIS; METABOLISM; PHYSIOLOGY; TANDEM MASS SPECTROMETRY; URINE;

ADULT; CARBON ISOTOPES; CHROMATOGRAPHY, LIQUID; CIRCADIAN RHYTHM; FOLIC ACID; FORMATES; GLYCINE; HUMANS; MALE; PURINES; TANDEM MASS SPECTROMETRY;

EID: 34147163880     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.metabol.2006.12.020     Document Type: Article

References (49)

1. Garrett R.H., and Grisham C.H. The synthesis and degradation of nucleotides. Biochemistry. 3rd ed. (2005), Thomson Brooks/Cole, Belmont, CA 853-878
2. Christensen K.E., and Mackenzie R.E. Mitochondrial one-carbon metabolism is adapted to the specific needs of yeast, plants and mammals. BioEssays 28 (2006) 595-605
3. Annison E.F. Studies on the volatile fatty acids of sheep blood with special reference to formic acid. Biochem J 58 (1954) 670-680
4. Hanzlik R.P., Fowler S.C., and Eells J.T. Absorption and elimination of formate following oral administration of calcium formate in female human subjects. Drug Metab Dispos 33 (2005) 282-286
5. Buchanan J.M., and Sonne J.C. The utilization of formate in uric acid synthesis. J Biol Chem 166 (1946) 781
6. Sonne J.C., Buchanan J.M., and Delluva A.M. Biological precursors of uric acid. I. The role of lactate, acetate, and formate in the synthesis of the ureide groups of uric acid. J Biol Chem 173 (1948) 69-79
7. 14. I. Purines and pyrimidines in the rat. J Biol Chem 186 (1950) 447-460
8. Drysdale G.R., Plaut G.W.E., and Lardy H.A. The relationship of folic acid to formate metabolism in the rat: formate incorporation into purines. J Biol Chem 193 (1951) 533-538
9. Sprinson D.B., and Rittenberg D. The metabolic reactions of carbon atom 2 of l-histidine. J Biol Chem 198 (1952) 655-661
10. Karlsson J.L., and Barker H.A. Biosynthesis of uric acid labeled with radioactive carbon. J Biol Chem 177 (1949) 597-599
11. Kikuchi G. The glycine cleavage system: composition, reaction mechanism, and physiological significance. Mol Cell Biochem 1 (1973) 169-187
12. Abrams R. Stability of the adenine ring structure in the rat. Biochim Biophys Acta 21 (1956) 439-440
13. Bennett E.L., and Karlsson H. Metabolism of adenine in mice. J Biol Chem 229 (1957) 39-50
14. Wyngaarden J.B., Blair A.E., and Hilley L. On the mechanism of overproduction of uric acid in patients with primary gout. J Clin Invest 37 (1958) 579-590
15. Villa L., Robecchi A., and Ballabio C.B. Physiopathology, clinical manifestations, and treatment of gout. Part 1. Physiopathology and pathogenesis. Arch Rheum Dis 17 (1958) 9-15
16. 15 into uric acid in normal and gouty subjects. Am J Med 25 (1958) 917-932
17. Gutman A.B., and Yü T.-F. An abnormality of glutamine metabolism in primary gout. Am J Med 35 (1963) 820-831
18. Krakoff I.H., and Balis M.E. Abnormalities of purine metabolism in human leukemia. Ann NY Acad Sci 113 (1964) 1043-1052
19. Stahelin H.B., Stokstad E.L.R., and Winchell H.S. Formate oxidation and its incorporation into uric acid in folic acid deficiency. J Nucl Med 11 (1970) 247-254
20. Gorman G.S., Tamura T., and Baggott J.E. Mass spectrometric method for detecting carbon 13 enrichment introduced by folate coenzymes in uric acid. Anal Biochem 321 (2003) 188-191
21. 2 breath tests. Am J Clin Nutr 33 (1980) 2375-2385
22. 2 enrichment. Am J Physiol: Res Environ Exerc Phys 56 (1984) 230-234
23. Sokal RR, Rohlf FJ. Biometry. The principles and practice of statistics in biological research. San Francisco, CA: W.H. Freeman, 1981, p. 447-50 and p. 782-7.
24. Vincent M.F., Marangos P.J., Gruber H.E., and Van den Berghe G. Inhibition by AICA riboside of gluconeogenesis in isolated rat hepatocytes. Diabetes 40 (1991) 1259-1266
25. Corton J.M., Gillespie J.G., Hawley S.A., and Hardie D.G. 5-Aminoimidazole-4-carboxamide ribonucleotide. A specific method for activating AMP-activated protein kinase in intact cells?. Eur J Biochem 229 (1995) 558-565
26. Javaux F., Vincent M.F., Wagner D.R., and Van den Berghe G. Cell-type specificity of inhibition of glycolysis by 5-amino-4-imidazolecarboxamide riboside. Lack of effect in rabbit cardiomyocytes and human erythrocytes, and inhibition in FTO-2B rat hepatoma calls. Biochem J 305 (1995) 913-919
27. Hardie D.G., and Hawley S.A. AMP-activated protein kinase: the energy charge hypothesis revisited. BioEssays 23 (2001) 1112-1119
28. Vincent M.F., Bontemps F., and Van den Berghe G. Substrate cycling between 5-amino-4-imidazolecarboxamide riboside and its monophosphate in isolated rat hepatocytes. Biochem Pharmacol 52 (1996) 999-1006
29. Perretta M.A., and Thomson R.Y. Effect of erythropoietine on incorporation of formate labelled with carbon-14 into the nucleic acids of normal rabbit tissues in vitro. Nature 190 (1961) 912
30. Hall R. Stimulation of purine synthesis in vitro in the calf thyroid by thyroid-stimulating hormone. J Biol Chem 238 (1963) 306-310
31. Matsuda Y., Kuroda Y., Kobayashi K., and Katunuma N. Comparative studies on glutamine, serine, and glycine metabolism in ureotelic and uricotelic animals. J Biochem (Tokyo) 73 (1973) 291-298
32. Bertino J.R., Simmons B., and Donohue D.M. Purification and properties of the formate-activating enzyme from erythrocyte. J Biol Chem 237 (1962) 1314-1318
33. Lowy B.E., Williams M.K., and London I.M. Enzymatic deficiencies of purine nucleotide synthesis in the human erythrocyte. J Biol Chem 237 (1962) 1622-1625
34. Wagner C., and Levitch M.E. The utilization of formate by human erythrocytes. Biochem Biophys Acta 304 (1973) 623-633
35. McGeer P.L., McGeer E.G., and Griffin M.C. Excretion of 4-amino-5-imidazolecarboxamide in human urine. Can J Biochem Physiol 39 (1961) 591-603
36. Sidi Y., and Mitchell B.S. Z-nucleotide accumulation in erythrocytes from Lesch-Nyhan patients. J Clin Invest 76 (1985) 2416-2419
37. Marie S., Heron B., Bitoun P., Timmerman T., Van den Berghe G., and Vincent M.-F. AICA-ribosiduria: a novel, neurologically devastating inborn error of purine biosynthesis caused by mutation of ATIC. Am J Hum Genet 74 (2004) 1276-1281
38. Murray A.W. The biological significance of purine salvage. Annu Rev Biochem 40 (1971) 811-826
39. Lowy B.A., and Lerner M.H. A role of liver adenosine in the renewal of the adenine nucleotides of human and rabbit erythrocytes. Adv Exp Biol Med 41A (1974) 129-139
40. Mager J., Dvilansky A., Razin A., Wind E., and Izak G. Turnover of purine nucleotides in human red blood cells. Isr J Med Sci 2 (1966) 297-301
41. Chagoya de Sánchez V., Hernández-Muňoz R., et al. Temporal variations of adenosine metabolism in human blood. Chronobiol Int 13 (1996) 163-177
42. Caperelli C.A., Benkovic P.A., Chettur G., and Benkovic S.J. Purification of a complex catalyzing folate cofactor synthesis and transformylation in de novo purine biosynthesis. J Biol Chem 255 (1980) 1885-1890
43. Smith G.K., Mueller W.T., Wasserman G.F., Taylor W.D., and Benkovic S.J. Characterization of the enzyme complex involving the folate-requiring enzymes of de novo purine biosynthesis. Biochemistry 19 (1980) 4313-4321
44. Casteels M., Croes K., Van Veldhoven P.P., and Mannaerts G.P. Peroxisomal localization of α-oxidation in human liver. J Inherit Metab Dis 20 (1997) 665-673
45. Howard W.J., Kerson L.A., and Appel S.H. Synthesis de novo of purines in slices of rat brain and liver. J Neurochem 17 (1970) 121-123
46. 14C into urinary uric acid in normal and porphyric human subjects. S Afr Med J 43 (1969) 961-964
47. Weinhouse S., and Friedmann B. A study of formate production in normal and folic acid-deficient rats. J Biol Chem 210 (1954) 423-433
48. Rabinowitz J.C., and Tabor H. The urinary excretion of formic acid and formiminoglutamic acid in folic acid deficiency. J Biol Chem 233 (1958) 252-255
49. Deacon R., Bottiglieri T., Chanarin I., Lumb M., and Perry J. Methylthioadenosine serves as a single carbon source to the folate co-enzyme pool in rat bone marrow cells. Biochim Biophys Acta 1034 (1990) 342-346