Apolipoprotein E ε4 allele is associated with Parkinson disease risk in a Mexican Mestizo population

Movement Disorders

Volumn 22, Issue 3, 2007, Pages 417-420

  López, Marisol ^a   Guerrero, Jorge ^b   Yescas, Petra ^b   Boll, Marie Catherine ^b   Familiar, Itziar ^b   Ochoa, Adriana ^b   Rasmussen, Astrid ^b   Alonso, María Elisa ^b  

^a DEPARTAMENTO DE SISTEMAS BIOLÓGICOS   (Mexico)

^b NATIONAL INSTITUTE OF NEUROLOGY AND NEUROSURGERY   (Mexico)

Author keywords

Age at onset; Apolipoprotein E; Parkinson disease

Indexed keywords

APOLIPOPROTEIN E; APOLIPOPROTEIN E4;

ADULT; AGED; ARTICLE; BRADYKINESIA; CLINICAL FEATURE; CONTROLLED STUDY; DNA POLYMORPHISM; ETHNICITY; FAMILIAL DISEASE; FAMILY HISTORY; FEMALE; GENE EXPRESSION; GENE FREQUENCY; GENETIC ASSOCIATION; GENOTYPE; HISPANIC; HUMAN; MAJOR CLINICAL STUDY; MALE; ONSET AGE; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RIGIDITY; RISK ASSESSMENT; TUMOR; COMPARATIVE STUDY; GENETIC PREDISPOSITION; GENETICS; MEXICO; MIDDLE AGED; RISK;

AGE OF ONSET; AGED; APOLIPOPROTEIN E4; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; MEXICO; MIDDLE AGED; PARKINSON DISEASE; RISK;

EID: 34147150135     PISSN: 08853185     EISSN: 15318257     Source Type: Journal    
DOI: 10.1002/mds.21340     Document Type: Article

References (15)

1. Samii A, Nutt JG, Ransom BR. Parkinson's disease. Lancet 2004;363:1783-1793.
2. Alonso ME, Otero E, D' Regules R, Figueroa HH. Parkinson's disease: a genetic study. Can J Neurol Sci 1986;13:248-251.
3. Kachergus J, Mata IF, Hulihan M, et al. Identification of a novel LRRK2 mutation linked to autosomal dominant parkinsonism: evidence of a common founder across European populations. Am J Hum Genet 2005;76:672-680.
4. Li YJ, Hauser MA, Scott WK, et al. Apolipoprotein E controls the risk and age at onset of Parkinson disease. Neurology 2004;62:2005-2009.
5. Maraganore DM, Farrer MJ, Hardy JA, McDonnell SK, Schaid DJ, Rocca WA. Case-control study of debrisoquine 4-hydroxylase, N-acetyltransferase 2, and apoliprotein E gene polymorphisms in Parkinson's disease. Mov Disord 2000;15:714-719.
6. Saunders AM, Strittmatter WJ, Schemel D, et al. Association of apolipoprotein E allele ε4 with late-onset familial and sporadic Alzheimer's disease. Neurology 1993;43:1467-1472.
7. Eerola J, Launes J, Hellström O, Tienari PJ. Apolipoprotein E (APOE), PARKIN and cathecol-o-methyltransferase (COMT) genes and susceptibility to sporadic Parkinson's disease in Finland. Neurosci Lett 2002;330:296-298.
8. The French Parkinson's Disease Genetics Study Group. Apolipoprotein E genotype in familial Parkinson's disease. J Neurol Neurosurg Psychiatry 1997;63:394-395.
9. Huang X, Chen PC, Poole C. ApoE-ε2 allele associated with higher prevalence of sporadic Parkinson disease. Neurology 2004;62:2198-2202.
10. Pankratz N, Byder I, Halter C, et al. Presence of an APOE4 allele results in significantly earlier onset of Parkinson disease and a higher risk with dementia. Mov Disord 2006;21:45-49.
11. Hixson JE, Vernier DT. Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with Hha I. J Lipid Res 1990;31:545-548.
12. Zareparsi S, Kaye J, Camicioli R, et al. Modulation of the age at onset of Parkinson's disease by apolipoprotein E genotypes. Ann Neurol 1997;42:655-658.
13. Lisker R, Ramírez V, Babinsky V. Genetic structure of autochthonous populations of Meso-America: Mexico. Hum Biol 1996;68:395-394.
14. Gómez M, Clark RM, Nath SK, et al. Genetic admixture of European FRDA genes is the cause of Friedreich ataxia in the Mexican population. Genomics 2004;84:779-784.
15. Ibarreta D, Gómez-Isla T, Portera-Sánchez A, Parrilla R, Ayuso MS. Apolipoprotein E genotype in Spanish patients of Alzheimer's or Parkinson's disease. J Neurol Sci 1995;134:146-149.