The relationship between ACE genotype and risk of severe hypoglycaemia in a large population-based cohort of children and adolescents with type 1 diabetes

Diabetologia

Volumn 50, Issue 5, 2007, Pages 965-971

  Bulsara, M K ^a,c   Holman, C D J ^a   Van Bockxmeer, F M ^a   Davis, E A ^b,c   Gallego, P H ^b   Beilby, J P ^d   Palmer, L J ^e   Choong, C ^a,b   Jones, T W ^b,c  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b PRINCESS MARGARET HOSPITAL FOR CHILDREN   (Australia)

^c UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^d PATHWEST LABORATORY MEDICINE   (Australia)

^e UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

ACE; ACE genotype; Angiotensin converting enzyme; Complications; Polymorphism; Severe hypoglycaemia; Type 1 diabetes mellitus

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE;

ADOLESCENT; ALLELE; ARTICLE; COHORT ANALYSIS; CONSCIOUSNESS; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; FOLLOW UP; GENE DELETION; GENE IDENTIFICATION; GENETIC ASSOCIATION; GENETIC RISK; GENOTYPE; HUMAN; HYPOGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; POPULATION RESEARCH; PRIORITY JOURNAL; PROSPECTIVE STUDY; SEIZURE;

ADOLESCENT; AUSTRALIA; CHILD; COHORT STUDIES; DIABETES MELLITUS, TYPE 1; FEMALE; GENOTYPE; HUMANS; HYPOGLYCEMIA; MALE; PEPTIDYL-DIPEPTIDASE A; POLYMERASE CHAIN REACTION; RISK ASSESSMENT; SEIZURES;

EID: 34147148605     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-007-0613-4     Document Type: Article

References (37)

1. Jones TW, Davis EA (2003) Hypoglycemia in children with type 1 diabetes: current issues and controversies. Pediatr Diabetes 4:143-150
2. Bulsara MK, Holman CDAJ, Davis EA, Jones TW (2004) The Impact of a decade of changing treatment on rates of severe hypoglycemia in a population-based cohort of children with type 1 diabetes. Diabetes Care 27:2293-2298
3. Cryer PE (2002) Hypoglycaemia: The limiting factor in the glycaemic management of Type I and Type II Diabetes. Diabetologia 45:937-948
4. Sovik O, Thordarson H (1999) Dead-in-bed syndrome in young diabetic patients. Diabetes Care 22(Suppl 2):B40-B42
5. Cryer PE (2005) Mechanisms of hypoglycemia-associated autonomic failure and its component syndromes in diabetes. Diabetes 54:3592-3601
6. Bulsara MK, Holman CDJ, Davis EA, Jones TW (2004) Evaluating risk factors associated with severe hypoglycaemia in epidemiology studies - what method should we use? Diabetic Medicine 21:914-919
7. The Diabetes Control and Complications Trial (DCCT), Epidemiology of Diabetes Interventions and Complications (EDIC) Research Group (1997) Clustering of long-term complications in families with diabetes in the diabetes control and complications trial. The Diabetes Control and Complications Trial Research Group. Diabetes 46:1829-1839
8. Pedersen-Bjergaard U, Agerholm-Larsen B, Pramming S, Hougaard P, Thorsteinsson B (2003) Prediction of severe hypoglycaemia by angiotensin-converting enzyme activity and genotype in Type 1 Diabetes. Diabetologia 46:89-96
9. Herings RMC, de Boer A, Leufkens HGM, Porsius A, Stricker BHC (1995) Hypoglycaemia associated with use of inhibitors of angiotensin converting enzyme. Lancet 345:1195-1198
10. Morris A, Boyle D, McMahon A et al (1997) ACE inhibitor use is associated with hospitalization for severe hypoglycemia in patients with diabetes. DARTS/MEMO Collaboration. Diabetes Audit and Research in Tayside, Scotland. Medicines Monitoring Unit. Diabetes Care 20:1363-1367
11. van Haeften TW, Kong N, Bates A et al (1995) ACE inhibitors and hypoglycaemia. Lancet 346:125-127
12. Petrie J, Morris A, Ueda S et al (1995) Do ACE inhibitors improve insulin sensitivity? Lancet 346:583-584
13. Strachan M, Frier B (1998) Risk of severe hypoglycemia in diabetes patients taking ACE inhibitors. Diabetes Care 21:470
14. Chaturvedi N, Fuller J (1998) ACE inhibitors and risk of hypoglycemia in people with diabetes. Diabetes Care 21:470-472
15. Rigat B, Hubert C, Alhenc-Gelas F, Cambien F, Corvol P, Soubrier F (1990) An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest 86:1343-1346
16. Morris BJ, Zee RYL, Schrader AP (1994) Different frequencies of angiotensin-converting enzyme genotypes in older hypertensive individuals. J Clin Invest 94:1085-1089
17. Gayagay G, Yu B, Hambly B et al (1998) Elite endurance athletes and the ACE I allele - the role of genes in athletic performance. Hum Genet 103:48-50
18. Montgomery HE, Marshall R, Hemingway H et al (1998) Human gene for physical performance. Nature 393:221-222
19. Taylor RR, Mamotte CDS, Fallon K, van Bockxmeer FM (1999) Elite athletes and the gene for angiotensin-converting enzyme. J Appl Physiol 87:1035-1037
20. Nordfeldt S, Samuelsson U (2003) Serum ACE predicts severe hypoglycemia in children and adolescents with type 1 diabetes. Diabetes Care 26:274-278
21. Pedersen-Bjergaard U, Agerholm-Larsen B, Pramming S, Hougaard P, Thorsteinsson B (2001) Activity of angiotensin-converting enzyme and risk of severe hypoglycaemia in type 1 diabetes mellitus. Lancet 357:1248-1253
22. Davis EA, Keating B, Byrne GC, Russell M, Jones TW (1997) Hypoglycemia: incidence and clinical predictors in a large population-based sample of children and adolescents with IDDM. Diabetes Care 20:22-25
23. Haynes A, Bower C, Bulsara MK, Jones TW, Davis EA (2004) Continued increase in the incidence of childhood Type 1 diabetes in a population-based Australian sample (1985-2002). Diabetologia 47:866-870
24. Haynes A, Bulsara MK, Bower C, Codde JP, Jones TW, Davis EA (2006) Independent effects of socioeconomic status and place of residence on the incidence of childhood type 1 diabetes in Western Australia. Pediatr Diabetes 7:94-100
25. Miller SA, Dykes DD, Polesky HF (1998) A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 16:1215
26. Rigat B, Hubert C, Corvol P, Soubrier R (1992) PCR detection of the insertion/deletion polymorphism of the human angiotensin converting enzyme gene (DCP1) (dipeptidyl carboxypeptidase 1). Nucleic Acids Res 20:1433
27. Shanmugam V, Sell KW, Saha BK (1993) Mistyping ACE heterozygotes. PCR Methods Appl 3:120-121
28. Alcolado J (1998) Genetics of diabetic complications. Lancet 351:230-231
29. Craig ME, Handelsman P, Donaghue KC et al (2002) Predictors of glycaemic control and hypoglycaemia in children and adolescents with type 1 diabetes from NSW and the ACT. Med J Aust 177:235-238
30. Rewers A, Chase HP, Mackenzie T et al (2002) Predictors of acute complications in children with type 1 diabetes. JAMA 287:2511-2518
31. Tiret L, Rigat B, Visvikis S et al (1992) Evidence, from combined segregation and linkage analysis, that a variant of the Angiotensin Iconverting Enzyme (ACE) gene controls plasma ACE levels. Am J Hum Genet 51:197-205
32. van Bockxmeer FM, Mamotte CDS, Burke V (2000) Angiotensin-converting enzyme gene polymorphism and premature coronary heart disease. Clin Sci 99:247-251
33. Bloem LJ, Manatunga AK, Pratt JH (1996) Racial difference in the relationship of Angiotensin I-coverting enzyme gene polymorphism to serum Angiotensin I-converting enzyme activity. Hypertension 27:62-66
34. Crisan D, Carr J (2000) Angiotensin I-converting enzyme: genotype and disease associations. J Mol Diagn 2:105-115
35. Morris BJ (1996) Hypothesis: An Angiotensin converting enzyme gentotype, present in one in three Caucasians, is associated with an increased mortality rate. Clin Exp Pharmacol Physiol 23:1-10
36. Geddes J, Zammitt NN, Warren RE, Ashby PJ, Deary IJ, Frier BM (2006) Does serum angiotensin converting enzyme (ACE) concentration predict risk of severe hypoglycemia in type 1 diabetes? American Diabetes Association Scientific Conference, Washington DC, USA
37. Holstein A, Plaschke A, Böttcher Y, Stumvoll M, Kovacs P (2006) The insertion/deletion polymorphism in the angiotensin-converting enzyme gene and hypoglycemia awareness in patients with type 1 Diabetes. Horm Metab Res 38:603-606