Angiotensin I-converting enzyme: Genotype and disease associations

Journal of Molecular Diagnostics

Volumn 2, Issue 3, 2000, Pages 105-115

  Crisan, Domnita ^a   Carr, Jeanne ^a  

^a WILLIAM BEAUMONT HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE;

CARDIOVASCULAR DISEASE; ENZYMOLOGY; GENETIC POLYMORPHISM; GENETICS; GENOTYPE; HUMAN; KIDNEY DISEASE; METABOLISM; PHYSIOLOGY; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVIEW;

CARDIOVASCULAR DISEASES; GENOTYPE; HUMANS; KIDNEY DISEASES; PEPTIDYL-DIPEPTIDASE A; POLYMORPHISM, GENETIC; RENIN-ANGIOTENSIN SYSTEM;

EID: 0034252565     PISSN: 15251578     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1525-1578(10)60624-1     Document Type: Review

References (111)

1. Cheng S, Grow, MA, Pallaud C, Klitz W, Erlich HA, Visvikis S, Chen JJ, Pullinger CR, Malloy WJ, Siest G, Kane JP: A multilocus genotyping assay for candidate markers of cardiovascular disease risk. Genome Res 1999, 9:936-949
2. Kuivenhoven JA, Jukema JW, Zwinderman AH, de Knijff P, McPherson R, Bruschke AVG, Lie K I, Kastelein JJP: The role of a common variant of the cholesteryl ester transfer protein gene in the progression of coronary atherosclerosis. N Engl J Med 1998, 338:86-93
3. Cohen-Haguenauer O, Soubrier F, Van Cong N, Serero S, Turleau C, Jegou C, Gross MS, Corvol P, Frezal J: Regional mapping of the human renin gene to 1q32 by in situ hybridisation. Ann Genet 1989, 32:16-20
4. Hadman JA, Mort YJ, Catanzaro DF, Tallam JT, Baxter JD, Morris BJ, Shine J: Primary structure of human renin gene. DNA 1984, 3:457-468
5. Gaillard I, Clauser E, Corvol P: Structure of human angiotensinogen gene. DNA 1989, 8:87-99
6. Gaillard-Sanchez I, Mattei MG, Clauser E, Corvol P: Assignment by in situ hybridisation of the angiotensinogen gene to chromosome band 1q4, the same region as the human renin gene. Hum Genet 1990, 84:341-343
7. Hubert C, Houot AM, Corvol P, Soubrier F: Structure of the angiotensin I-converting enzyme gene. Two alternate promoters correspond to evolutionary steps of a duplicated gene. J Biol Chem 1991, 266: 15377-15383
8. Mattei MG, Hubert C, Alhenc-Gelas F, Roeckel N, Corvol P, Soubrier F: Angiotensin I converting enzyme gene is on chromosome 17. Cytogenet Cell Genet 1989, 51:1041-1045
9. Szpirer C, Riviere M, Szpirer J, Levan G, Guo DF, Iwai N, Inagami T: Chromosomal assignment of human and rat hypertension candidate genes: type 1 angiotensin II receptor genes and the SA gene. J Hypertens 1993, 11:919-925
10. Koike G, Horiuchi M, Yamada T, Szpirer C, Jacob HJ, Dzau VJ: Human type 2 angiotensin II receptor gene: cloned, mapped to the X chromosome, and its mRNA is expressed in the human lung. Biochem Biophys Res Commun 1994, 203:1842-1850
11. Davis GK, Roberts DH: Molecular genetics of the renin-angiotensin system: implications for angiotensin II receptor blockade. Pharmacol Ther 1997, 75:43-50
12. Sawa H, Tokuchi F, Mochizuki N, Endo Y, Furuta Y, Shinohara T, Takada A, Kawaguchi H, Yasuda H, Nagashima K: Expression of the angiotensinogen gene and localization of its protein in the human heart. Circulation 1992, 86:138-146
13. Paul M, Wagner J, Dzau VJ: Gene expression of the renin-angiotensin system in human tissues. Quantitative analysis by the polymerase chain reaction. J Clin Invest 1993, 91:2058-2064
14. Morgan K, Wharton J, Webb JC, Keogh BE, Smith PL, Taylor KM, Oakley CM, Polak JM, Cleland JG: Co-expression of renin-angiotensin system component genes in human atrial tissue. J Hypertens 1994, 12:S11-S19
15. Jan Danser AH, Schalekamp MADH: Is there an internal cardiac renin-angiotensin system? Heart 1996, 76(Suppl 3):28-32
16. Regitz-Zagrosek V, Friedel N, Heymann A, Bauer P, Neuss M, Rolfs A, Steffen C, Hildebrandt A, Hetzer R, Fleck E: Regulation, chamber localization, and subtype distribution of angiotensin II receptors in human hearts. Circulation 1995, 91:1461-1471
17. Stoll M, Steckelings UM, Paul M, Bottari SP, Metzger R, Unger T: The angiotensin AT2 receptor mediates inhibition of cell proliferation in coronary endothelial cells. J Clin Invest 1995, 95:651-657
18. Urata H, Kinoshita A, Misono KS, Bumpus FM, Husain A: Identification of a highly specific chymase as the major angiotensin II-forming enzyme in the human heart. J Biol Chem 1990, 265:22348-22357
19. Urata H, Boehm KD, Philip A, Kinoshita A, Gabrovsek J, Bumpus FM, Husain A: Cellular localization and regional distribution of an angiotensin II-forming chymase in the heart. J Clin Invest 1993, 91:1269-1281
20. Rigat B, Hubert C, Alhenc-Gelas F, Cambien F, Corvol P, Soubrier F: An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest 1990, 86:1343-1346
21. Cambien F, Alhenc-Gelas F, Herbeth B, Andre JL, Rakotovao R, Gonzales MF, Allegrini J, Bloch C: Familial resemblance of plasma angiotensin-converting enzyme level: the Nancy study. Am J Hum Genet 1988, 43:774-780
22. Rigat B, Hubert C, Corvol P, Soubrier F: PCR detection of the insertion/deletion polymorphism of the human angiotensin converting enzyme gene (DCP 1) (dipeptidyl carboxypeptidase 1). Nucleic Acids Res 1992, 20:1433
23. Shanmugam V, Sell KW, Saha BK: Mistyping ACE heterozygotes. PCR Methods Appl 1993, 3:120-121
24. Perna NT, Batzer MA, Deininger PL, Stoneking M: Alu insertion polymorphism: a new type of marker for human population studies. Hum Biol 1992, 64:641-648
25. Tiret L, Rigat B, Visvikis S, Breda C, Corvol P, Cambien F, Soubrier F: Evidence from combined segregation and linkage analysis that a variant of the angiotensin I-converting enzyme (ACE) gene controls plasma ACE levels. Am J Hum Genet 1992, 51:197-205
26. Ribichini F, Steffenino G, Dellavalle A, Matullo G, Colajanni E, Camilla T, Vado A, Benetton G, Uslenghi E, Piazza A: Plasma activity and insertion/deletion polymorphism of angiotensin I-converting enzyme. A major risk factor and a marker of risk for coronary stent restenosis. Circulation 1998, 97:147-154
27. Malik FS, Lavie CJ, Mehra MR, Milani RV, Re RN: Renin-angiotensin system: genes to bedside Am Heart J 1997, 134:514-527
28. Philipp CS, Dilley A, Saidi P, Evatt B, Austin H, Zawadsky J, Harwood D, Ellingsen D, Barnhart E, Phillips DJ, Hooper WC: Deletion polymorphism in the angiotensin converting enzyme gene as a thrombophilic risk factor after hip arthroplasty. Thromb Haemost 1998, 80: 869-873
29. Costerousse O, Allegrini J, Lopez M, Alhenc-Gelas F: Angiotensin I converting enzyme in human circulating mononuclear cells: genetic polymorphism of expression in T-lymphocytes. Biochem J 1993, 290: 33-40
30. Marre M, Bernadet P, Gallois Y, Savagner F, Guyene T, Hallab M, Cambien F, Passa P, Alhenc-Gelas F: Relationship between angiotensin I converting enzyme gene polymorphism, plasma levels, and diabetic retinal and renal complications. Diabetes 1994, 43:384-388
31. Mizuiri S, Hemmi H, Inoue A, Takano M, Kadomatsu S, Tanimoto H, Tanegashima M, Hayashi I, Fushimi T, Hasegawa A: Renal hemodynamic changes induced by captopril and angiotensin-converting enzyme gene polymorphism. Nephron 1997, 75:310-314
32. Sasaki M, Oki T, Luchi A, Tabata T, Yamada H, Manabe K, Fukuda K, Abe M, Ito S: Relationship between angiotensin converting enzyme gene polymorphism and the effects of enalapril on left ventricular hypertrophy and impaired diastolic filling in essential hypertension: M-mode and pulsed Doppler echocardiographic studies. J Hypertens 1996, 14:1403-1408
33. Ohmichi N, Iwai N, Uchida Y, Shichiri G, Nakamura Y, Kinoshita M: Relationship between the response to the angiotensin converting enzyme inhibitor imidapril and the angiotensin converting enzyme genotype. Am J Hypertens 1997, 10:951-955
34. Danser AH, Schalekamp MA, Bax WA, van den Brink AM, Saxena PR: Effect of the deletion/insertion polymorphism. Circulation 1995, 92: 1387-1388
35. Gayagay G, Yu B, Hambly B, Boston T, Hahn A, Celermajer DS, Trent RJ: Elite endurance athletes and the ACE I allele-the role of genes in athletic performance. Hum Genet 1998, 103:48-50
36. Ishigami T, Iwamoto T, Tamura K, Yamaguchi S, Iwasawa K, Uchino K, Umemura S, Ishii M: Angiotensin I converting enzyme (ACE) gene polymorphism and essential hypertension in Japan. Ethnic differences of ACE genotype. Am J Hypertens 1995, 8:95-97
37. Morris BJ: Hypothesis: an angiotensin converting enzyme genotype, present in one in three Caucasians, is associated with increased mortality rate. Clin Exp Pharmacol Physiol 1996, 23:1-10
38. Schachter F, Faure-Delanef L, Guenot F, Rouger H, Froguel P, Lesueur-Ginot L, Cohen D: Genetic associations with human longevity at the APOE and ACE loci. Nat Genet 1994, 6:29-32
39. Ehlers MRW, Riordan JF: Angiotensin-converting enzyme: new concepts concerning its biological role. Biochemistry 1989, 28:5311-5313
40. McGeer EG, Singh EA: Angiotensin-converting enzyme in cortical tissue in Alzheimer's and some other neurological diseases. Dementia 1992, 3:299-303
41. Jorgensen JOL, Christiansen JS: Brave new senescence: GH therapy in adults. Lancet 1993, 341:1247
42. Cambien F, Poirier O, Lecerf L, Evans A, Cambou JP, Arveiler D, Luc G, Bard JM, Bara L, Richard S, Tiret L, Amouyel P, Alhenc-Gelas F, Soubrier F: Deletion polymorphism in the gene for angiotensin converting enzyme is a potent risk factor for myocardial infarction. Nature 1992, 359:641-644
43. Cambien F, Costerousse O, Tiret L, Poirier O, Lecerf L, Gonzales F, Evans A, Arveiler D, Cambou JP, Luc G, Rakotavao R, Ducimetiere P, Soubrier F, Alhenc-Gelas F: Plasma level and gene polymorphism of angiotensin-converting enzyme in relation to myocardial infarction. Circulation 1994, 90:669-676
44. Nakai K, Itoh C, Miura Y, Hotta K, Musha T, Itoh T, Miyakawa T, Iwasaki R, Hiramori K: Deletion polymorphism of the angiotensin I-converting enzyme gene is associated with serum ACE concentration and increased risk for CAD in the Japanese. Circulation 1994, 90:2199-2202
45. Beohar N, Damaraju S, Prather A, Yu QT, Raizner A, Kleiman NS, Roberts R, Marian AJ: Angiotensin I-converting enzyme genotype DD is a risk factor for coronary artery disease. J Invest Med 1995, 43:275-280
46. Kamitani A, Raguki H, Higaki J, Ohishi M, Shi SJ, Takami S, Nakata Y, Higashino Y, Fujii K, Mikami H, Miki T, Ogihara T: Enhanced predictability of myocardial infarction in Japanese by combined genotype analysis. Hypertension 1995, 25:950-953
47. Schuster H, Wienker TF, Stremmler U, Noll B, Steinmetz A, Luft FC: An angiotensin-converting enzyme gene variant is associated with acute myocardial infarction in women but not in men. Am J Cardiol 1995, 76:601-603
48. Alvarez R, Reguero JR, Batalla A, Iglesias-Cubero G, Cortina A, Alvarez V, Coto E: Angiotensin-converting enzyme and angiotensin II receptor 1 polymorphism: association with early coronary disease. Cardiovasc Res 1998, 40:375-379
49. Tiret L, Kee F, Poirier O, Nicaud N, Lecerf L, Evans AE, Cambon J-P, Arveiler D, Luc G, Amouyel P, Cambien F: Deletion polymorphism in the angiotensin-converting enzyme gene associated with parental history of myocardial infarction. Lancet 1993, 341:991-992
50. Badenhop RF, Wang XL, Wilcken DEL: Angiotensin-converting enzyme genotype in children and coronary events in their grandparents. Circulation 1995, 91:1655-1658
51. Evans AE, Poirier O, Kee F, Lecerf L, McCrum E, Falconer T, Crane J, O'Rourke DF, Cambien F: Polymorphisms of the angiotensin-converting-enzyme gene in subjects who die from coronary heart disease. Q J Med 1994, 87:211-214
52. Pfeffer MA, Braunwald E, Moye LA, Basta L, Brown EJ, Cuddy TE, Davis BR, Geltman EM, Goldman S, Flaker GC, Klein M, Lamas GA, Packer M, Rouleau J, Rouleau JL, Rutherford J, Wertheimer JH, Hawkins CM: Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction: results of the Survival and Ventricular Enlargement Trial. N Engl J Med 1992, 327:669-677
53. Yusuf S, Pepine CJ, Garces C, Pauleur M, Salem D, Kostis J, Benedict CM, Rousseau M, Bourassa M, Pitt B: Effect of enalapril on myocardial infarction and unstable angina in patients with low ejection fractions. Lancet 1992, 340:1173-1178
54. Pepine CJ: The effects of angiotensin-converting enzyme inhibition on endothelial dysfunction: potential role in myocardial ischemia. Am J Cardiol 1998, 82:233-273
55. Sayer JW, Timmis AD: Angiotensin-converting enzyme inhibitors and coronary artery disease. Cardiovasc Drugs Ther 1996, 10:631-637
56. The Heart Outcomes Prevention Evaluation Study (HOPE): Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. N Engl J Med 2000, 342:145-153
57. Francis GS: ACE inhibition in cardiovascular disease. N Engl J Med 2000, 42:201-202
58. Casala PN, Milner M, Devereux RB, Zulio G, Harshfield G, Pickering TG, Spitzer MC, Laragh JH: Value of echocardiographic left ventricular mass in predicting cardiovascular morbid events in hypertensive men. Circulation 1985, 72(Suppl III):130
59. Schunkert H, Hense HW, Holmer SR, Slender M, Perz S, Keil U, Lorell BH, Riegger GA: Association between a deletion polymorphism of the angiotensin-converting enzyme gene and left ventricular hypertrophy. N Engl J Med 1994, 330:1634-1638
60. Iwai N, Ohmichi N, Nakamura Y, Kinoshita M: DD genotype of the angiotensin converting enzyme gene is a risk factor for left ventricular hypertrophy. Circulation 1994, 90:2622-2628
61. Prasad N, O'Kane KP, Johnstone HA, Wheeldon NM, McMahon AD, Webb DJ, MacDonald TM: The relationship between blood pressure and left ventricular mass in essential hypertension is observed only in the presence of the angiotensin converting enzyme deletion allele. Q J Med 1994, 87:659-662
62. Riegger GAJ: Role of the renin-angiotensin system as a risk factor for control of morbidity and mortality in coronary artery disease. Cardiovasc Drugs Ther 1996, 10:613-615
63. Ledru F, Blanchard D, Battaglia S, Jeunemaitre X, Courbon D, Guize L, Guermonprez J-L, Ducimetiere P, Diebold B: Relation between severity of coronary artery disease, left ventricular function and myocardial infarction, and influence of the ACE I/D gene polymorphism. Am J Cardiol 1998, 82:160-165
64. Schmidt S, Van Hooft IMS, Grobbee DE, Ganten D, Ritz E: Polymorphism of the angiotensin I-converting enzyme gene is apparently not related to high blood pressure: Dutch Hypertension and Offspring Study. J Hypertens 1993, 11:345-348
65. Jeunemaitre X, Lifton RP, Hunt SC, Williams RR, Lalouel J-M: Absence of linkage between the angiotensin converting enzyme locus and human essential hypertension. Nat Genet 1992, 1:72-75
66. Nakano Y, Oshima T, Watanabe M, Matsuura H, Kajiyama G, Kambe M: Angiotensin I-converting enzyme gene polymorphism and acute response to captopril in essential hypertension. Am J Hypertens 1997, 10:1064-1068
67. Zee RYL, Lou YK, Morris BJ: Association of a polymorphism of the angiotensin I-converting enzyme gene with essential hypertension. Biochem Biophys Res Commun 1991, 184:9-15
68. Dilley A, Austin H, Hooper WC, Latty C, Ribeiro MJ, Wenger NK, Silva V, Rawlins P, Evatt B: Relation of three genetic traits to venous thrombosis in an African-American population. Am J Epidemiol 1998, 147:1-6
69. Schmidt S, Ritz E: Genetics of the renin-angiotensin system and renal disease: a progress report. Curr Opin Nephrol Hypertens 1997, 6:146-151
70. Yoshida H, Ichikawa I, Sakai O: Role of angiotensin-converting enzyme gene polymorphism in progressive loss of renal function in chronic renal diseases. Contrib Nephrol 1996, 118:249-253
71. Parving H-H, Jacobsen P, Tarnow L, Rossing P, Lecerf L, Poirier O, Cambien F: Effect of deletion polymorphism of angiotensin converting enzyme gene on progression of diabetic nephropathy during inhibition of angiotensin converting enzyme: observational follow up study. Br Med J 1996, 313:591-594
72. Jacobsen P, Rossing K, Rossing P, Tarnow L, Mallet C, Poirier O, Cambien F, Parving H-H: Angiotensin converting enzyme gene polymorphism and ACE inhibition in diabetic nephropathy. Kidney Int 1998, 53:1002-1006
73. Penno G, Chaturvedi N, Talmud PJ, Cotroneo P, Manto A, Nannipieri M, Luong L-A, Fuller JH, and the EUCLID Study Group: Effect of angiotensin-converting enzyme (ACE) gene polymorphism on progression of renal disease and the influence of ACE inhibition in IDDM patients. Diabetes 1998, 47:1507-1511
74. Van Essen GG, Rensma PL, de Zeeuw D, Sluiter WJ, Scheffer H, Apperloo AJ, de Jong PE: Association between angiotensin-converting enzyme gene polymorphism and failure of renoprotective therapy. Lancet 1996, 347:94-95
75. Gonzalo A, Telleria D, San Millan JL, Ortuno J: Angiotensin-converting enzyme gene polymorphism and antiproteinuric response to renoprotective therapy. Nephrol Dial Transplant 1998, 13:1050-1051
76. Serruys PW, de Jaegere P, Kiemeneij F, Macaya C, Rutsch W, Heyndrickx G, Emanuelsson H, Marco J, Legrand V, Materne P, Belardi J, Sigwart U, Colombo A, Goy JJ, van den Heuvel P, Delcan J, Morel MA, for the Benestent Study Group: A comparison of balloon-expandable-stent implantation with balloon angioplasty in patients with coronary artery disease. N Engl J Med 1994, 331:489-495
77. Fischman DL, Leon MB, Bairn DS, Schatz RA, Savage MP, Penn I, Detre K, Veltri L, Ricci D, Nobuyoshi M, Cleman M, Heuser R, Almond D, Teirstein PS, Fish RD, Colombo A, Brinker J, Moses J, Shaknovich A, Hirshfeld J, Bailey S, Ellis S, Rake R, Goldberg S, for the Stent Restenosis Study Investigators: A randomized comparison of coronary-stent placement and balloon angioplasty in the treatment of coronary artery disease. N Engl J Med 1994, 331:496-501
78. Amant C, Bauters C, Bodart J-C, Lablancha J-M, Grollier G, Danchin N, Hamon M, Richard F, Helbecque N, McFadden EP, Amouyel P, Bertrand ME: D allele of the angiotensin I-converting enzyme is a major risk factor for restenosis after coronary stenting. Circulation 1997, 96:56-60
79. Hoffmann R, Mintz GS, Dussaillant GR, Popma JJ, Pichard AD, Satler LF, Kent KM, Griffin J, Leon M: Patterns and mechanisms of in-stent restenosis: a serial intravascular ultrasound study. Circulation 1996, 94:1247-1254
80. Ribichini F, Steffenino G, Dellavalle A, Vado A, Colajanni E, Matullo G, Piazza A, Uslenghi E, Ambrose J: The pattern (focal/diffuse) of angiographic in-stent restenosis is associated to the I/D polymorphism of the angiotensin converting enzyme gene. Circulation 1997, 98:1-87
81. Pratt RE, Dzau VJ: Pharmacological strategies to prevent restenosis: lessons learned from blockade of the renin-angiotensin system. Circulation 1996, 93:848-852
82. Daemen MJAP, Lombardi DM, Bosman FT, Schwartz SM: Angiotensin II induces smooth muscle cell proliferation in the normal and injured rat arterial wall. Circ Res 1991, 68:450-456
83. Powell JS, Clozel JP, Muller RKM, Kuhn H, Hefti F, Hosang M, Baumgartner HR: Inhibitors of angiotensin-converting enzyme prevent myointimal proliferation after vascular injury. Science 1989, 245:186-188
84. Clozel JP, Hess P, Michael C, Schietinger K, Baumgartner HR: Inhibition of converting enzyme and neointima formation after vascular injury in rabbits and guinea pigs. Hypertension 1991, 18(Suppl I):I-155-1-159
85. Bonithon-Kopp C, Ducimetiere P, Touboul PJ, Feve JM, Billaud E, Courbon D, Heraud V: Plasma angiotensin-converting enzyme activity and carotid wall thickening. Circulation 1994, 89:952-954
86. Castellano M, Muiesan ML, Rizzoni D, Beschi M, Pasini G, Cinelli A, Salvetti M, Porteri E, Bettoni G, Kreutz R, Lindpaintner K, Rosei EA: Angiotensin-converting enzyme I/D polymorphism and arterial wall thickness in a general population: the Vobarno Study. Circulation 1995, 91:2721-2724
87. Ribichini T, Wijns W: Genetic markers for the prediction of in-stent restenosis. Stent 1999, 2:8-15
88. Lindpaintner K, Pfeffer MA, Kreutz R, Stampfer MJ, Grodstein F, LaMotte F, Buring J, Hennekens CH: A prospective evaluation of an angiotensin converting enzyme gene polymorphism and the risk of ischemic heart disease. N Engl J Med 1995, 332:706-711
89. Jeunemaitre X, Ledru F, Battaglia S, Guillanneuf M-T, Courbon D, Dumont C, Damon O, Guize L, Guermonprez J-L, Diebold B, Ducimetiere P: Genetic polymorphisms of the renin-angiotensin system and angiographic extent and severity of coronary artery disease: the CORGENE Study. Hum Genet 1997, 99:66-73
90. Agerholm-Larsen B, Tybjaerg-Hansen A, Frikke-Schmidt R, Gronholdt M-LM, Jensen G, Nordestgaard BG: ACE gene polymorphism as a risk factor for ischemic cerebrovascular disease. Ann Intern Med 1997, 127:346-355
91. Agerholm-Larsen B, Nordestgaard BG, Steffensen R, Sorensen TIA, Jensen G, Tybjaerg-Hansen A: ACE gene polymorphism: ischemic heart disease and longevity in 10,150 individuals: a case referent and retrospective cohort study based on the Copenhagen City Heart Study. Circulation 1997, 95:2358-2367
92. Agerholm-Larsen B, Nordestgaard BG, Tybjaerg-Hansen A: ACE gene polymorphism in cardiovascular disease. Meta-analysis of small and large studies in whites. Arterioscler Thromb Vasc Biol 2000, 20:484-492
93. Schieffer B, Drexler H: ACE gene polymorphism and coronary artery disease. A question of persuasion or statistical confusion? Arterioscler Thromb Vasc Biol 2000, 20:281-282
94. Jeunmaitre X, Soubrier F, Kotelevtsev YV, Lifton RP, Williams CS, Charru A, Hunt SC, Hopkins PN, Williams RR, Lalouel J-M, Corvol P: Molecular basis of human hypertension: role of angiotensinogen. Cell 1992, 71:169-180
95. O'Byrne S, Caulfield M: Genetics of hypertension. Therapeutic implications. Drugs 1998, 56:203-214
96. Tiret L, Blanc H, Ruidavets J-B, Arveiler D, Luc G, Jeunemaitre X, Tichet J, Mallet C, Poirier O, Plouin P-F, Cambien F: Gene polymorphisms of the renin-angiotensin system in relation to hypertension and parental history of myocardial infarction and stroke: the PE-GASE Study. J Hypertens 1998, 16:37-44
97. Berge KE, Berg K: Polymorphisms at the angiotensinogen (AGT) and angiotensin II type 1 receptor (AT1R) loci and normal blood pressure. Clin Genet 1998, 53:214-219
98. Mondorf UF, Russ A, Wiesemann A, Herrero M, Oremek G, Lenz T: Contribution of angiotensin I converting enzyme gene polymorphism and angiotensinogen gene polymorphism to blood pressure regulation in essential hypertension. Am J Hypertens 1998, 11:174-183
99. Katsuya T, Koike G, Yee TW, Sharpe N, Jackson R, Norton R, Horiuchi M, Pratt RE, Doan VJ, MacMahon S: Association of angiotensinogen gene T235 variant with increased risk of coronary heart disease. Lancet 1995, 345:1600-1603
100. Winkelmann BR, Russ AP, Nauck M, Klein B, Bohm BO, Maier V, Zotz R, Matheis G, Wolf A, Wieland H, Gros W, Galton DJ, Marz W: Angiotensinogen M235T polymorphism is associated with plasma angiotensinogen and cardiovascular disease. Am Heart J 1999, 137:698-705
101. Ichihara S, Yokota M, Fujimara T, Kato S, Hirayama H, Tsunekawa A, Inagaki H, Takatsu F, Nakashima N, Yamada Y: Lack of association between variants of the angiotensinogen gene and the risk of coronary artery disease in middle-aged Japanese men. Am Heart J 1997, 134:260-265
102. Bonnardeaux A, Davies E, Jeunemaitre X, Fery I, Charru A, Clauser E, Tiret L, Cambien F, Corvol P, Soubrier F: Angiotensin II type 1 receptor gene polymorphism in human essential hypertension. Hypertension 1994, 24:63-69
103. Benetos A, Gautier S, Ricard S, Topouchian J, Asmar R, Poirier O, Larosa E, Guize L, Safar M, Soubrier F, Cambien F: Influence of angiotensin converting enzyme and angiotensin II type 1 receptor gene polymorphisms on aortic stiffness in normotensive and hypertensive patients. Circulation 1996, 94:698-703
104. Tiret L, Bonnardeaux A, Poirier O, Ricard S, Marques-Vidal P, Evans A, Arveiler D, Luc G, Kee F, Ducimetiere P, Soubrier F, Cambien F: Synergistic effects of angiotensin converting enzyme and angiotensin II type 1 receptor gene polymorphisms on risk of myocardial infarction. Lancet 1994, 344:910-913
105. Berge KE, Bakken A, Bohn M, Erikssen J, Berg K: A DNA polymorphism at the angiotensin II type 1 receptor (AT1R) locus and myocardial infarction. Clin Genet 1997, 52:71-76
106. Hamon M, Amant C, Bauters C, Richard F, Helbecque N, Passard F, McFadden EP, Lablanche J-M, Bertrand ME, Amouyel P: Dual determination of angiotensin converting enzyme and angiotensin II type 1 receptor genotypes as predictors of restenosis after coronary angioplasty. Am J Cardiol 1998, 81:79-81
107. Hamon M, Amant C, Bauters C, Richard F, Helbecque N, McFadden E, Lablanche J-M, Betrand M, Amouyel P: Association of angiotensin converting enzyme and angiotensin II type 1 receptor genotypes with left ventricular function and mass in patients with angiographically normal coronary arteries. Heart 1997, 77:502-505
108. 1166 polymorphism contributes to cardiac hypertrophy in subjects with hypertrophic cardiomyopathy. Hypertension 1998, 32:825-830
109. Gardemann A, Nguyen QD, Humme J, Stricker J, Katz N, Tillmanns H, Hehrlein FW, Rau M, Haberbosch W: Angiotensin II type 1 receptor A1166C gene polymorphism. Eur Heart J 1998, 19:1657-1665
110. Girerd X, Hanon O, Mourad JJ, Boutouyrie P, Laurent S, Jeunemaitre X: Lack of association between renin-angiotensin system, gene polymorphisms, and wall thickness of the radial and carotid arteries. Hypertension 1998, 32:579-583
111. Castellano M, Muiesan ML, Beschi M, Rizzoni D, Cinelli A, Salvetti M, Pasini G, Porteri E, Bettoni G, Zulli R, Agabiti-Rosei E: Angiotensin II type 1 receptor A/C 1166 polymorphism. Relationships with blood pressure and cardiovascular structure. Hypertension 1996, 28: 1076-1080