Effect of oral linoleic and γ-linolenic acid on meibomian gland dysfunction

Cornea

Volumn 26, Issue 3, 2007, Pages 260-264

  Pinna, Antonio ^a   Piccinini, Paola ^a   Carta, Francesco ^a  

^a UNIVERSITY OF SASSARI   (Italy)

Author keywords

linolenic acid; 6 fatty acids; Linoleic acid; Meibomian gland dysfunction; Therapy

Indexed keywords

GAMMA LINOLENIC ACID; LINOLEIC ACID; MEDILAR; OMEGA 6 FATTY ACID; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BLEPHARITIS; CLINICAL TRIAL; CONJUNCTIVA; CONJUNCTIVAL HYPEREMIA; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORNEA; DRUG EFFECT; EYE CARE; EYELID; EYELID DISEASE; EYELID EDEMA; FEMALE; FOAM; HUMAN; HYGIENE; HYPEREMIA; MAJOR CLINICAL STUDY; MALE; MEIBOMIAN GLAND; MEIBOMIAN GLAND DYSFUNCTION; OBSTRUCTION; OUTCOME ASSESSMENT; PRIORITY JOURNAL; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; SECRETION; SELF EVALUATION; SLIT LAMP; STAINING; STATISTICAL SIGNIFICANCE; TEAR FILM; TREATMENT DURATION; TURBIDITY;

ADMINISTRATION, ORAL; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; EYELID DISEASES; FEMALE; GAMMA-LINOLENIC ACID; HUMANS; LINOLEIC ACID; MALE; MEIBOMIAN GLANDS; MIDDLE AGED; QUESTIONNAIRES; TREATMENT OUTCOME;

EID: 34147145291     PISSN: 02773740     EISSN: None     Source Type: Journal    
DOI: 10.1097/ICO.0b013e318033d79b     Document Type: Article

References (24)

1. Driver P, Lemp MA. Seborrhea and meibomian gland dysfunction. In: Krachmer JH, Mannis MJ, Holland EJ, eds. Cornea. St. Louis, MO: Mosby-Year Book; 1997:625-632.
2. McCulley JP, Dougherty JM, Denau DG. Classification of chronic blepharitis. Ophthalmology. 1982;89:1173-1180.
3. Tiffany JM. The role of meibomian secretion in the tears. Trans Ophthalmol Soc U K. 1985;104:396-401.
4. Mathers WD. Ocular evaporation in meibomian gland dysfunction and dry eye. Ophthalmology. 1993;100:347-351.
5. Shine WE, McCulley JP. Role of wax ester fatty alcohols in chronic blepharitis. Invest Ophthalmol Vis Sci. 1993;34:3515-3521.
6. Shine WE, McCulley JP. Polar lipids in human meibomian gland secretions. Curr Eye Res. 2003;26:89-94.
7. Olson MC, Korb DR, Greiner JV. Increase in tear film lipid layer thickness following treatment with warm compresses in patients with meibomian gland dysfunction. Eye Contact Lens. 2003;29:96-99.
8. Nagymihalyi A, Dikstein S, Tiffany JM. The influence of eyelid temperature on the delivery of meibomian oil. Exp Eye Res. 2004;78:367-370.
9. Calder PC, Zurier RB. Polyunsatered fatty acids and rheumatoid arthritis. Curr Opin Clin Nutr Metab Care. 2001;4:115-121.
10. Barabino S, Rolando M, Camicione P, et al. Systemic linoleic and gammalinolenic acid therapy in dry eye syndrome with an inflammatory component. Cornea. 2003;22:97-101.
11. Aragona P, Bucolo C, Spinella R, et al. Systemic omega-6 essential fatty acid treatment and PGE1 tear content in Sjögren's syndrome patients. Invest Ophthalmol Vis Sci. 2005;46:4474-4479.
12. Macri A, Rolando M, Pfugfelder S. A standardized visual scale for evaluation of tear fluorescein clearance. Ophthalmology. 2000;107:1338-1343.
13. Wu D, Meydani M, Leka LS, et al. Effect of dietary supplementation with black currant seed oil on the immune response of healthy subjects. Am J Clin Nutr. 1999;70:536-543.
14. Devchand PR, Keller H, Peters JM, et al. The PPAR-leukotriene B4 pathway to inflammation control. Nature. 1996;384:39-44.
15. Johnson MM, Swan DD, Surette ME, et al. Dietary supplementation with gamma-linolenic acid alters fatty acid content and eicosanoid production in healthy humans. J Nutr. 1997;127:1435-1444.
16. Levin G, Duffin KL, Obukowicz MG, et al. Differential metabolism of dihomo-gamma-linolenic acid and arachidonic acid by cyclo-oxigenase-1 and cyclo-oxigenase-2: implications for cellular synthesis of prostaglandin E1 and prostaglandin E2. Biochem J. 2002;365:489-496.
17. Simopoulos AP. The Mediterranean diets: what is so special about the diet of Greece? The scientific evidence. J Nutr. 2001;131:3065(S)-3073(S).
18. Zurier RB. Prostaglandins. Their potential in clinical medicine. Postgrad Med. 1980;68:70-81.
19. Hoyng PF, Verbey N, Thong L, et al. Topical prostaglandins inhibit trauma-induced inflammation in the rabbit eye. Invest Ophthalmol Vis Sci. 1986;27:1217-1225.
20. Zurier RB, Quagliata F. Effect of prostaglandin E1 on adjuvant arthritis. Nature. 1971;234;304-305.
21. Belch JJF, Muir A. Evening primrose oil and borage oil in rheumatologic conditions. Am J Clin Nutr. 2000;71(suppl):352-356.
22. Nicolaides N, Kaitaranta JK, Rawdah TN, et al. Meibomian gland studies: comparison of steer and human lipids. Invest Ophthalmol Vis Sci. 1981;20:522-536.
23. Dougherty JM, Osgood JK, McCulley JP. The role of wax and sterol ester fatty acids in chronic blepharitis. Invest Ophthalmol Vis Sci. 1991;32:1932-1937.
24. Shine WE, McCulley JP. The role of cholesterol in chronic blepharitis. Invest Ophthalmol Vis Sci. 1991;32:2272-2280.