Characterization of the Saccharomyces cerevisiae galactose mutarotase/UDP-galactose 4-epimerase protein, Gal10p

FEMS Yeast Research

Volumn 7, Issue 3, 2007, Pages 366-371

  Scott, Aaron ^a   Timson, David J ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

Aldose epimerase; Bifunctional enzyme; Galactose metabolism; Leloir pathway; SDR family enzyme; UDP glucose

Indexed keywords

DIMER; EPIMERASE; FUNGAL ENZYME; FUNGAL PROTEIN; GALACTOSE; GALACTOSE MUTAROTASE; GLUCOSE; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE GLUCOSE 4 EPIMERASE;

ARTICLE; CARBOHYDRATE METABOLISM; CATABOLISM; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME KINETICS; FUNGUS IDENTIFICATION; NONHUMAN; PROTEIN CROSS LINKING; PROTEIN DOMAIN; PROTEIN EXPRESSION; SACCHAROMYCES CEREVISIAE; STEADY STATE; YEAST;

BINDING SITES; CARBOHYDRATE EPIMERASES; GALACTOSE; GLUCOSE; KINETICS; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TRANS-ACTIVATORS; UDPGLUCOSE 4-EPIMERASE;

ESCHERICHIA COLI; SACCHAROMYCES CEREVISIAE;

EID: 34147144066     PISSN: 15671356     EISSN: 15671364     Source Type: Journal    
DOI: 10.1111/j.1567-1364.2006.00204.x     Document Type: Article

References (46)

1. Abadjieva A, Pauwels K, Hilven P & Crabeel M (2001) A new yeast metabolon involving at least the two first enzymes of arginine biosynthesis: acetylglutamate synthase activity requires complex formation with acetylglutamate kinase. J Biol Chem 276: 42869-42880.
2. Bailey JM, Fishman PH & Pentchev PG (1966) Mutarotase in higher plants: distribution and properties. Science 152: 1270-1272.
3. Beebe JA, Arabshahi A, Clifton JG, Ringe D, Petsko GA & Frey PA (2003) Galactose mutarotase: pH dependence of enzymatic mutarotation. Biochemistry 42: 4414-4420.
4. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254.
5. Brahma A & Bhattacharyya D (2004) UDP-galactose 4-epimerase from Kluyveromyces fragilis. Evidence for independent mutarotation site. Eur J Biochem 271: 58-68.
6. Caputto R, Leloir LF, Trucco RE, Cardini CE & Paladini AC (1949) The enzymatic transformation of galactose into glucose derivatives. J Biol Chem 179: 497-498.
7. Cardini CE & Leloir LF (1953) Enzymic phosphorylation of galactosamine and galactose. Arch Biochem Biophys 45: 55-64.
8. Christacos NC, Marson MJ, Wells L, Riehman K & Fridovich-Keil JL (2000) Subcellular localization of galactose-1-phosphate uridylyltransferase in the yeast Saccharomyces cerevisiae. Mol Genet Metab 70: 272-280.
9. Elsas LJ IInd & Lai K (1998) The molecular biology of galactosemia. Genet Med 1: 40-48.
10. Frey PA (1996) The Leloir pathway: a mechanistic imperative for three enzymes to change the stereochemical configuration of a single carbon in galactose. FASEB J 10: 461-470.
11. Frolova E, Johnston M & Majors J (1999) Binding of the glucose-dependent Mig1p repressor to the GAL1 and GAL4 promoters in vivo: regulation by glucose and chromatin structure. Nucleic Acids Res 27: 1350-1358.
12. Goffeau A, Barrell BG, Bussey H et al. (1996) Life with 6000 genes. Science 274: 546, 563-567.
13. Holden HM, Rayment I & Thoden JB (2003) Structure and function of enzymes of the Leloir pathway for galactose metabolism. J Biol Chem 278: 43885-43888.
14. Holden HM, Thoden JB, Timson DJ & Reece RJ (2004) Galactokinase: structure, function and role in type II galactosemia. Cell Mol Life Sci 61: 2471-2484.
15. Howard SM & Heinrich MR (1965) The anomeric specificity of yeast galactokinase. Arch Biochem Biophys 110: 395-400.
16. Kindzelskii AL, Ueki T, Michibata H, Chaiworapongsa T, Romero R & Petty HR (2004) 6-Phosphogluconate dehydrogenase and glucose-6-phosphate dehydrogenase form a supramolecular complex in human neutrophils that undergoes retrograde trafficking during pregnancy. J Immunol 172: 6373-6381.
17. Leloir LF (1951) The enzymatic transformation of uridine diphosphate glucose into a galactose derivative. Arch Biochem 33: 186-190.
18. Li LK, Chase AM & Lapedes SL (1964) Kinetics of mutarotation of glucose catalyzed by purified hog kidney mutarotase. J Cell and Comp Physiol 64: 283-291.
19. Majumdar S, Ghatak J, Mukherji S, Bhattacharjee H & Bhaduri A (2004) UDP galactose 4-epimerase from Saccharomyces cerevisiae. A bifunctional enzyme with aldose 1-epimerase activity. Eur J Biochem 271: 753-759.
20. Marquardt D (1963) An algorithm for least squares estimation of nonlinear parameters. SIAM J Appl Math 11: 431-441.
21. Mitchell CG (1996) Identification of a multienzyme complex of the tricarboxylic acid cycle enzymes containing citrate synthase isoenzymes from Pseudomonas aeruginosa. Biochem J 313: 769-774.
22. Mulhern SA, Fishman PH, Kusiak JW & Bailey JM (1973) Physical characteristics and chemi-osmotic transformations of mutarotases from various species. J Biol Chem 248: 4163-4173.
23. Novelli G & Reichardt JK (2000) Molecular basis of disorders of human galactose metabolism: past, present, and future. Mol Genet Metab 71: 62-65.
24. Ovadi J (1988) Old pathway - new concept: control of glycolysis by metabolite-modulated dynamic enzyme associations. Trends Biochem Sci 13: 486-490.
25. Partis MD, Griffiths DG, Roberts GC & Beechey RD (1983) Cross-linking of protein by ω-maleimido alkanoyl N-hydroxysuccinimido esters. J Protein Chem 2: 263-277.
26. Petry KG & Reichardt JK (1998) The fundamental importance of human galactose metabolism: lessons from genetics and biochemistry. Trends Genet 14: 98-102.
27. Roper JR & Ferguson MA (2003) Cloning and characterisation of the UDP-glucose 4′-epimerase of Trypanosoma cruzi. Mol Biochem Parasitol 132: 47-53.
28. Seiboth B, Karaffa L, Sandor E & Kubicek C (2002) The Hypocrea jecorina gal10 (uridine 5′-diphosphate-glucose 4-epimerase-encoding) gene differs from yeast homologues in structure, genomic organization and expression. Gene 295: 143-149.
29. Sellick CA & Reece RJ (2005) Eukaryotic transcription factors as direct nutrient sensors. Trends Biochem Sci 30: 405-412.
30. Sidjanin DJ, McElwee J, Miller B & Aguirre GD (2005) Cloning of canine galactokinase (GALK1) and evaluation as a candidate gene for hereditary cataracts in Labrador retrievers. Anim Genet 36: 265-266.
31. Smith LD, Budgen N, Bungard SJ, Danson MJ & Hough DW (1989) Purification and characterization of glucose dehydrogenase from the thermoacidophilic archaebacterium Thermoplasma acidophilum. Biochem J 261: 973-977.
32. Thoden JB & Holden HM (2002) High resolution X-ray structure of galactose mutarotase from Lactococcus lactis. J Biol Chem 277: 20854-20861.
33. Thoden JB & Holden HM (2005) The molecular architecture of galactose mutarotase/UDP-galactose 4-epimerase from Saccharomyces cerevisiae. J Biol Chem 280: 21900-21907.
34. Thoden JB, Frey PA & Holden HM (1996) Crystal structures of the oxidized and reduced forms of UDP-galactose 4-epimerase isolated from Escherichia coli. Biochemistry 35: 2557-2566.
35. Thoden JB, Wohlers TM, Fridovich-Keil JL & Holden HM (2000) Crystallographic evidence for Tyr 157 functioning as the active site base in human UDP-galactose 4-epimerase. Biochemistry 39: 5691-5701.
36. Thoden JB, Wohlers TM, Fridovich-Keil JL & Holden HM (2001) Human UDP-galactose 4-epimerase. Accommodation of UDP-N-acetylglucosamine within the active site. J Biol Chem 276: 15131-15136.
37. Thoden JB, Kim J, Raushel FM & Holden HM (2002) Structural and kinetic studies of sugar binding to galactose mutarotase from Lactococcus lactis. J Biol Chem 277: 45458-45465.
38. Thoden JB, Timson DJ, Reece RJ & Holden HM (2004) Molecular structure of human galactose mutarotase. J Biol Chem 279: 23431-23437.
39. Timson DJ (2005) Functional analysis of disease-causing mutations in human UDP-galactose 4-epimerase. FEBS J 272: 6170-6177.
40. Timson DJ (2006) The structural and molecular biology of type III galactosemia. IUBMB Life 58: 83-89.
41. Timson DJ & Reece RJ (2003) Identification and characterisation of human aldose 1-epimerase. FEBS Lett 543: 21-24.
42. 2+-ATPase activity. Pharmacol Toxicol 91: 254-257.
43. Velot C, Mixon MB, Teige M & Srere PA (1997) Model of a quinary structure between Krebs TCA cycle enzymes: a model for the metabolon. Biochemistry 36: 14271-14276.
44. Watford M (1989) Channeling in the urea cycle: a metabolon spanning two compartments. Trends Biochem Sci 14: 313-314.
45. Wilkinson JF (1949) The pathway of adaptive fermentation in yeast. Biochem J 44: 460-467.
46. Wohlers TM & Fridovich-Keil JL (2000) Studies of the V94M-substituted human udpgalactose-4-epimerase enzyme associated with generalized epimerase-deficiency galactosaemia. J Inherit Metab Dis 23: 713-729.