Calcium-mediated triggered activity is an underlying cellular mechanism of ectopy originating from the pulmonary vein in dogs

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 292, Issue 4, 2007, Pages

  Hirose, Masamichi ^a   Laurita, Kenneth R ^b  

^a SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

Delayed afterdepolarizations; High resolution optical mapping; Ligament of marshall; Pituitary adenylate cyclase activating polypeptide

Indexed keywords

CALCIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; VERAPAMIL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL FUNCTION; CONTROLLED STUDY; ECTOPIC TISSUE; HEART ATRIUM FIBRILLATION; HEART ATRIUM PACING; MALE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PULMONARY VEIN;

ACTION POTENTIALS; ANIMALS; ANTI-ARRHYTHMIA AGENTS; ATRIAL FIBRILLATION; AUTONOMIC NERVOUS SYSTEM; CALCIUM; DOGS; HEART; HEART ATRIA; LIGAMENTS; MALE; PACEMAKER, ARTIFICIAL; PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE; PULMONARY VEINS; VERAPAMIL;

EID: 34147138208     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00826.2006     Document Type: Article

References (37)

1. Arora R, Verheule S, Scott L, Navarrete A, Katari V, Wilson E, Vaz D, Olgin JE. Arrhythmogenic substrate of the pulmonary veins assessed by high-resolution optical mapping. Circulation 107: 1816-1821, 2003.
2. Bayly PV, KenKnight BH, Rogers JM, Hillsley RE, Ideker RE, Smith WM. Estimation of conduction velocity vector fields from epicardial mapping data. IEEE Trans Biomed Eng 45: 563-571, 1998.
3. Bettoni M, Zimmermann M. Autonomic tone variations before the onset of paroxysmal atrial fibrillation. Circulation 105: 2753-2759, 2002.
4. Burashnikov A, Antzelevitch C. Delayed afterdepolarization activity as the basis for acetylcholine-induced tachyarrhythmias recorded in arterially perfused canine right atria (Abstract). Circulation 102: II-323, 2000.
5. Chen SA, Hsieh MH, Tai CT, Tsai CF, Prakash VS, Yu WC, Hsu TL, Ding YA, Chang MS. Initiation of atrial fibrillation by ectopic beats originating from the pulmonary veins: electrophysiological characteristics, pharmacological responses, and effects of radiofrequency ablation. Circulation 100: 1879-1886, 1999.
6. Chen YC, Chen SA, Chen YJ, Chan P, Lin CI. T-type calcium channel regulates the arrhythmogenic activity of pulmonary vein cardiomyocytes (Abstract). PACE 26: 1043, 2003.
7. Chen YJ, Chen SA, Chang MS, Lin CI. Arrhythmogenic activity of cardiac muscle in pulmonary veins of the dog: implication for the genesis of atrial fibrillation. Cardiovasc Res 48: 265-273, 2000.
8. Chen YJ, Chen SA, Chen YC, Yeh HI, Chan P, Chang MS, Lin CI. Effects of rapid atrial pacing on the arrhythmogenic activity of single cardiomyocytes from pulmonary veins: implication in initiation of atrial fibrillation. Circulation 104: 2849-2854, 2001.
9. Chen YJ, Chen SA, Chen YC, Yeh HI, Chang MS, Lin CI. Electrophysiology of single cardiomyocytes isolated from rabbit pulmonary veins: implication in initiation of focal atrial fibrillation. Basic Res Cardiol 97: 26-34, 2002.
10. 2+ channel currents in vascular smooth muscle cells: involvement of PKC and PKA. FASEB J 10: 1310-1317, 1996.
11. De Bakker JM, Ho SY, Hocini M. Basic and clinical electrophysiology of pulmonary vein ectopy. Cardiovasc Res 54: 287-294, 2002.
12. Doshi RN, Wu TJ, Wu TJ, Yashima M, Kim YH, Ong JJC, Cao JM, Hwang C, Yashar P, Fishbein MC, Karagueuzian HS, Chen PS. Relation between ligament of Marshall and adrenergic atrial tachyarrhythmia. Circulation 100: 876-883, 1999.
13. Egdell RM, De Souza AI, Macleod KT. Relative importance of SR load and cytoplasmic calcium concentration in the genesis of aftercontractions in cardiac myocytes. Cardiovasc Res 47: 769-777, 2000.
14. Haissaguerre M, Jais P, Shah DC, Takahashi A, Hocini M, Quiniou G, Garrigue S, Le Mouroux A, Le Metayer P, Clementy J. Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary veins. N Engl J Med 339: 659-666, 1998.
15. Hirose M, Furukawa Y, Lakhe M, Chiba S. Regional differences in cardiac effects of pituitary adenylate cyclase-activating polypeptide-27 in the isolated dog heart. Eur J Pharmacol 349: 269-276, 1998.
16. Hirose M, Furukawa Y, Nagashima Y, Lakhe M, Chiba S. Pituitary adenylate cyclase-activating polypeptide-27 causes a biphasic chronotropic effect and atrial fibrillation in autonomically decentralized, anesthetized dogs. J Pharmacol Exp Ther 283: 478-487, 1997.
17. Hirose M, Leatmanoratn Z, Laurita KR, Carlson MD. Mechanism for pituitary adenylate cyclase-activating polypeptide-induced atrial fibrillation. J Cardiovasc Electrophysiol 12: 1381-1386, 2001.
18. Hocini M, Ho SY, Kawara T, Linnenbank AC, Potse M, Shah D, Jaïs P, Janse MJ, Haïssaguerre M, De Bakker JMT. Electrical conduction in canine pulmonary veins-electrophysiological and anatomic correlation. Circulation 105: 2442-2448, 2002.
19. 2+ release contributes to automaticity in cat atrial pacemaker cells. J Physiol 524: 415-422, 2000.
20. Hwang C, Wu TJ, Doshi RN, Peter CT, Chen PS. Vein of Marshall cannulation for the analysis of electrical activity in patients with focal atrial fibrillation. Circulation 101: 1503-1505, 2000.
21. Katra RP, Laurita KR. Cellular mechanism of calcium-mediated triggered activity in the heart. Circ Res 96: 535-542, 2005.
22. Laurita KR, Singal A. Mapping action potentials and calcium transients simultaneously from the intact heart. Am J Physiol Heart Circ Physiol 280: H2053-H2060, 2001.
23. Mandapati R, Skanes A, Chen J, Berenfeld O, Jalife J. Stable microreentrant sources as a mechanism of atrial fibrillation in the isolated sheep heart. Circulation 101: 194-199, 2000.
24. Masani F. Node-like cells in the myocardial layer of the pulmonary vein of rats: an ultrastructural study. J Anat 145: 133-142, 1986.
25. Patterson E, Po SS, Scherlag BJ, Lazzara R. Triggered firing in pulmonary veins initiated by in vitro autonomic nerve stimulation. Heart Rhythm 2: 624-631, 2005.
26. Schauerte P, Scherlag BJ, Patterson E, Scherlag MA, Matsudaria K, Nakagawa H, Lazzara R, Jackman WM. Focal atrial fibrillation: experimental evidence for a pathophysiologic role of the autonomic nervous system. J Cardiovasc Electrophysiol 12: 592-599, 2001.
27. Scherlag BJ, Yamanashi WS, Schauerte P, Scherlag M, Sun YX, Hou YM, Jackman WM, Lazzara R. Endovascular stimulation within the left pulmonary artery to induce slowing of heart rate and paroxysmal atrial fibrillation. Cardiovasc Res 54: 470-475, 2002.
28. Scherlag BJ, Yeh BK, Robinson MJ. Inferior interatrial pathway in the dog. Circ Res 31: 18-35, 1972.
29. Schuessler RB, Rosenshtraukh LV, Boineau JP, Bromberg BI, Cox JL. Spontaneous tachyarrhythmias after cholinergic suppression in the isolated perfused canine right atrium. Circ Res 69: 1075-1087, 1991.
30. Song Y, Thedford S, Lerman BB, Belardinelli L. Adenosine-sensitive afterdepolarizations and triggered activity in guinea pig ventricular myocytes. Circ Res 70: 743-753, 1992.
31. Tan AY, Li H, Wachsmann-Hogiu S, Chen LS, Chen PS, Fishbein MC. Autonomic innervation and segmental muscular disconnections at the human pulmonary vein-atrial junction: implications for catheter ablation of atrialpulmonary vein junction. J Am Coll Cardiol 48: 132-143, 2006.
32. Vermeulen JT, McGuire MA, Opthof T, Coronel R, de Bakker JM, Klopping C, Janse MJ. Triggered activity and automaticity in ventricular trabeculae of failing human and rabbit hearts. Cardiovasc Res 28: 1547-1554, 1994.
33. Vigh S, Arimura A, Koves K, Somogyvari-Vigh A, Sitton J, Fermin CD. Immunohistochemical localization of the neuropeptide, pituitary adenylate cyclase activating polypeptide (PACAP), in human and primate hypothalamus. Peptides 12: 313-318, 1991.
34. Wang J, Liu L, Feng J, Nattel S. Regional and functional factors determining induction and maintenance of atrial fibrillation in dogs. Am J Physiol Heart Circ Physiol 271: H148-H158, 1996.
35. 2+-induced delayed afterdepolarizations in cat atrial myocytes. Circulation 96: 1275-1281, 1997.
36. Wit A, Cranefield P. Triggered and automatic activity in the canine coronary sinus. Circ Res 41: 435-445, 1977.
37. Zimmermann M, Kalusche D. Fluctuation in autonomic tone is a major determinant of sustained atrial arrhythmia in patients with focal ectopy originating from the pulmonary veins. J Cardiovasc Electrophysiol 12: 285-291, 2001.