Linking preclinical and clinical whole-body physiologically based pharmacokinetic models with prior distributions in NONMEM

European Journal of Clinical Pharmacology

Volumn 63, Issue 5, 2007, Pages 485-498

  Langdon, Grant ^a   Gueorguieva, Ivelina ^b   Aarons, Leon ^c   Karlsson, Mats ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b ELI LILLY AND COMPANY   (United States)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Bayesian analysis; Diazepam; NONMEM; Physiologically based pharmacokinetic models; Prior distributions

Indexed keywords

DIAZEPAM;

ANIMAL TISSUE; ARTICLE; ASSAY; BAYES THEOREM; BOOTSTRAPPING; CALIBRATION; CASE STUDY; CLINICAL STUDY; COMPARATIVE STUDY; COMPUTER PROGRAM; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DRUG DISTRIBUTION; EVALUATION; FEMALE; HUMAN; HUMAN TISSUE; INFORMATION; MALE; MODEL; NONHUMAN; NONMEM; NONPARAMETRIC TEST; PARAMETER; PERFORMANCE; PHYSIOLOGY; PLASMA CONCENTRATION-TIME CURVE; POPULATION; PRIORITY JOURNAL; RAT; SENSITIVITY ANALYSIS;

ANIMALS; ANTICONVULSANTS; BAYES THEOREM; COMPUTER SIMULATION; DIAZEPAM; DRUG EVALUATION, PRECLINICAL; FEMALE; HUMANS; MALE; MODELS, ANIMAL; MODELS, BIOLOGICAL; NONLINEAR DYNAMICS; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SOFTWARE; STATISTICS, NONPARAMETRIC; TISSUE DISTRIBUTION;

EID: 34147137825     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00228-007-0264-x     Document Type: Article

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