Effects of different cyclodextrins on the morphology, loading and release properties of poly (DL-lactide-co-glycolide)-microparticles containing the hypnotic agent etizolam

Journal of Microencapsulation

Volumn 24, Issue 3, 2007, Pages 214-224

  Lopedota, A ^a   Cutrignelli, A ^a   Trapani, A ^a   Boghetich, G ^b   Denora, N ^a   Laquintana, V ^a   Trapani, G ^a   Liso, G ^a  

^a UNIVERSITY OF BARI   (Italy)

^b POLITECNICO DI BARI   (Italy)

Author keywords

Biodegradable polymers; Cyclodextrins; Encapsulation; Etizolam; Microparticles

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; CYCLODEXTRIN DERIVATIVE; DRUG CARRIER; ETIZOLAM; HYPNOTIC AGENT; POLYGLACTIN; POLYMER; SOLVENT;

ARTICLE; BIODEGRADABILITY; CHEMICAL REACTION KINETICS; CHEMICAL STRUCTURE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DELIVERY SYSTEM; EMULSION; EVAPORATION; FEASIBILITY STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHILICITY; IN VITRO STUDY; MICROENCAPSULATION; MODULATION; QUANTITATIVE ANALYSIS; SUSTAINED DRUG RELEASE; SUSTAINED RELEASE FORMULATION; X RAY ANALYSIS;

CALORIMETRY, DIFFERENTIAL SCANNING; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYCLODEXTRINS; DIAZEPAM; HYPNOTICS AND SEDATIVES; MICROSCOPY, ELECTRON, SCANNING; PARTICLE SIZE; POLYGLACTIN 910; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; X-RAY DIFFRACTION;

EID: 34147105506     PISSN: 02652048     EISSN: 14645246     Source Type: Journal    
DOI: 10.1080/02652040601058152     Document Type: Article

References (15)

1. Bibby, DC, Davies, NM and Tucker, IG (2000) Mechanisms by which cyclodextrins modify drug release from polymeric drug delivery systems. International Journal of Pharmacy, 197, pp. 1-11.
2. Charney, DS, Mihic, SJ and Harris, RA (2001) Hypnotics and sedatives. The pharmacological basis of therapeutics., pp. 399-427. McGraw-Hill Medical Publishing Division, New York
3. Crotts, G. and Park, TG (1995) Preparation of porous and nonporous biodegradable polymeric hollow microspheres. Journal of Controlled Release, 35, pp. 91-105.
4. Dash, AK, Khin-Khin, A. and Suryanarayanan, R. (2002) X-Ray powder diffractometric method for quantitation crystalline drug in microparticulate systems. I. Microspheres. Journal of Pharmaceutical Science, 91, pp. 983-990.
5. De Rosa, G., Quaglia, F., La Rotonda, MI, Appel, M., Alphandary, H. and Fattal, E. (2002) Poly(lactide-co-glycolide) microspheres for the controlled release of oligonucleotide/polyethylenimine complexes. Journal of Pharmaceutical Science, 91, pp. 790-799.
6. Duchene, D., Wouessidjewe, D. and Ponchel, G. (1999) Cyclodextrins and carrier systems. Journal of Controlled Release, 62, pp. 263-268.
7. Fracasso, C., Confalonieri, S., Garattini, S. and Caccia, S. (1991) Single and multiple dose pharmacokinetics of etizolam in healthy subjects. European Journal of Pharmacology, 40, pp. 181-185.
8. Freytag, T., Dashevsky, A., Tillman, L., Hardee, GE and Bodmeier, R. (2000) Improvement of the encapsulation efficiency of oligonucleotide-containing biodegradable microspheres. Journal of Controlled Release, 69, pp. 197-207.
9. Huang, Y-Y, Chung, T-W and Tzeng, T. (1997) Drug release from PLA/PGA microparticulates. International Journal of Pharmacology, 156, pp. 9-15.
10. McDowell, JL (2003) Tossing and turning. Sleep disorders rob millions of Americans of needed rest., pp. 19-20. Modern drug discovery
11. Pistel, KF and Kissel, T. (2000) Effects of salt addition on the microencapsulation of proteins using w/o/w double emulsion technique. Journal of Microencapsulation, 17, pp. 467-483.
12. Schlicher, EJAM, Postma, NS, Zuidema, J., Talsma, H. and Hennink, WE (1997) Preparation and characterization of poly(D,L-lactic-co-glycolic acid) microspheres containing desferrioxamine. International Journal of Pharmacology, 153, pp. 335-345.
13. Singh, UV and Udupa, N. (1997) In vitro characterization of methotrexate loaded (polylactic-co-glycolic) acid microspheres and antitumor efficacy in Sarcoma-180 mice bearing tumor. Pharmaceutica Acta Helvetica, 72, pp. 165-173.
14. Trapani, G., Lopedota, A., Boghetich, G., Latrofa, A., Franco, M., Sanna, E. and Liso, G. (2003) Encapsulation and release of the hypnotic agent zolpidem from biodegradable polymer microparticles containing hydroxypropyl-β-cyclodextrin. International Journal of Pharmaceutics, 268, pp. 47-57.
15. Zannou, EA, Streng, WH and Stella, VJ (2001) Osmotic properties of sulfobutylether and 2-hydroxypropyl-β-cyclodextrins. Pharmaceutical Research, 18, pp. 1226-1231.